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This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]
[中文简述(自动翻译):]  这个基因编码的支架蛋白,在细胞外信号调节激酶的功能(ERK)级联。该蛋白质是由促分裂原活化蛋白结合蛋白相互作用蛋白定位于晚期内涵体和特异性结合MAP激酶激酶MAP2K1 / MEK1,MAP激酶MAPK3 / ERK1和MAP激酶MAPK1 / ERK2。在小鼠的直向同源基因的研究表明,它调节晚期胞内体流量和细胞增殖。编码多种亚型选择性剪接的转录物变体已经观察到这种基因。该基因的假基因位于染色体13的长臂[由RefSeq的,2011年8月提供]
LAMTOR3基因(以及对应的蛋白质)的细胞分布位置:
LAMTOR3基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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