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Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
[中文简述(自动翻译):]  核浆转运,以信号和能源依赖的过程,发生通过嵌入在核膜核孔复合物。含有核定位信号(NLS)的蛋白质的进口要求NLS导入受体,输入蛋白α和β亚基也称为karyopherins的异源二聚体。输入蛋白的α结合的含有NLS-货物在细胞质和输入蛋白测试码头在核孔复合物的细胞质侧的复合物。在三磷酸核苷存在下,小GTP结合蛋白冉,复数移动进入核孔复合物与输入蛋白亚基解离。输入蛋白的α进入核质及其乘客蛋白和输入蛋白测试保持在所述孔。输入蛋白β和核孔蛋白的FG重复之间的相互作用通过孔复合体是必不可少的易位。由该基因编码的蛋白质是输入蛋白β家族的一个成员。已发现该基因编码不同亚型的两个转录变异体。 [由RefSeq的,2013年2月提供]
KPNB1基因(以及对应的蛋白质)的细胞分布位置:
KPNB1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| HIV Infections | 0.12 | 1 | 0 | CTD_human |
| Dengue Fever | 0.00272435 | 1 | 0 | LHGDN |
| Infection | 0.00272435 | 1 | 0 | LHGDN |
| Malignant neoplasm of breast | 0.002367032 | 1 | 0 | GAD |
| Malignant Peripheral Nerve Sheath Tumor | 0.000542884 | 2 | 0 | BeFree |
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