IFNL3(interferon, lambda 3) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

19q13.13
基因染色体位置图

基因简述

基因简述

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  这个基因编码远亲I型干扰素和IL-10的家族的细胞因子。这个基因，白细胞介素28A（IL28A），和白介素29（IL29）三种形成映射到19q13染色体区域的细胞因子基因簇密切相关的细胞因子的基因。可以由病毒感染引起的三种基因编码的细胞因子的表达。所有三种细胞因子已显示出与由白介素10受体，β（IL10RB）和白介素28受体，α（IL28RA）的异二聚体II类细胞因子受体相互作用。 [由RefSeq的，2008年7月提供]

OMIM数据库中对IFNL3基因的介绍     Wikipedia数据库中对IFNL3基因的介绍

基因序列

基因序列

IFNL3基因的碱基序列：[NCBI]

基因突变

基因突变

IFNL3基因的碱基突变：           显示全部snp
rs628973       rs629008       rs629976       rs630388       rs4803217       rs4803221       rs4803222       rs8102358       rs8103142       rs8107030       rs11322783       rs11881222       rs11882871       rs12971396       rs12979731       rs12979860       rs28416813       rs62120527       rs67461793       rs71169578       rs71356848       rs71356849       rs73555604       rs74446185       rs74597329       rs75158108       rs75964389       rs77811741       rs111531283       rs112885693       rs112990542       rs113703374       rs114424160       rs114541631       rs116484909       rs117436747       rs117648444      
rs137902769       rs138031714       rs138525614       rs138562018       rs138893424       rs139076671       rs139176035       rs139782233       rs140300212       rs140489681       rs140585624       rs140951294       rs141228207       rs141536970       rs141678286       rs141779226       rs141891277       rs142118702       rs142346548       rs142437843       rs142981501       rs143748522       rs143935261       rs143958949       rs144005418       rs144430183       rs144507168       rs144570763       rs145428712       rs145703495       rs146179451       rs146276429       rs147152333       rs147679979       rs148017150       rs148069151       rs148543092       rs149779855       rs149832972       rs150308118       rs150569967       rs150748693       rs150891559       rs151331735       rs181637919       rs184805858       rs186768149       rs188088762       rs192457886       rs193049619       rs199518159       rs199623483       rs199632578       rs199662821       rs199677823       rs199693585       rs199698161       rs199801376       rs199847794       rs199949612       rs199950179       rs199952257       rs199999531       rs200133361       rs200165597       rs200180353       rs200225591       rs200272719       rs200289435       rs200419716       rs200429365       rs200546901       rs200551112       rs200621665       rs200651236       rs200672838       rs200719718       rs200763837       rs200768273       rs200783610       rs200888162       rs200889156       rs200909158       rs201018323       rs201093376       rs201104473       rs201110405       rs201120334       rs201228830       rs201252721       rs201278888       rs201344311       rs201412210       rs201418207       rs201422642       rs201448158       rs201456689       rs201540002       rs201547505       rs201562370       rs201579699       rs201676231       rs201680991       rs201746548       rs201850111       rs201851186       rs201888594       rs201895612       rs201991079       rs202028512       rs202101632       rs202102885       rs202126177       rs202129388       rs202143862       rs202184450       rs367845605       rs368072808       rs368234815       rs368572576       rs368595723       rs369378118       rs369774544       rs370209610       rs371130259       rs371681575       rs371967173       rs372502110       rs372735927       rs373142618       rs373577185       rs373670222       rs374551528       rs375318753       rs375683590       rs375801248       rs376167807       rs376448576       rs376519075       rs398034584       rs527995036       rs528325648       rs528391055       rs528458265       rs528511184       rs528628590       rs529144656       rs529681749       rs529745947       rs529794067       rs529808308       rs530084581       rs530584064       rs530769055       rs531634151       rs531913445       rs531986190       rs532987588       rs533259477       rs533736359       rs534977938       rs536136564       rs536671954       rs536732660       rs536943593       rs537209318       rs537937279       rs538615394       rs538783572       rs540004251       rs540120208       rs540245209       rs540316223       rs540384185       rs540643436       rs541447480       rs541510645       rs543196001       rs543740434       rs544019546       rs544229826       rs544382874       rs544442278       rs545865452       rs546666114       rs546792340       rs546819402       rs546893122       rs547928604       rs548672694       rs549676428       rs549745336       rs550495003       rs550880562       rs551733738       rs552030798       rs552356829       rs552432622       rs552619713       rs554272851       rs555600193       rs556019038       rs556913664       rs557735544       rs557850947       rs558853778       rs558986012       rs560602940       rs561741200       rs561802910       rs561804461       rs561926520       rs561982462       rs562801062       rs562873397       rs562926037       rs562968930       rs563194654       rs564052289       rs564179579       rs564293856       rs564496003       rs564786597       rs565598171       rs566060837       rs566123974       rs566628781       rs567075689       rs567114759       rs567255282       rs567322623       rs567323142       rs568360702       rs569399725       rs569567930       rs570739705       rs572986164       rs573045424       rs573796380       rs573859828       rs574073896       rs574801123       rs575171031       rs575300382       rs576352388       rs576537005       rs577414432       rs578007730       rs745590073       rs745600531       rs745678059       rs745893438       rs746052822       rs746231316       rs746917398       rs747041025       rs747255187       rs747605145       rs747622311       rs748051718       rs748295128       rs748387416       rs748576869       rs748760288       rs749027981       rs749248363       rs749849966       rs749961151       rs750217885       rs750265243       rs750426703       rs750728589       rs750747183       rs751012686       rs751108220       rs751160364       rs751656258       rs751900525       rs752454179       rs752709116       rs753011204       rs753385390       rs753602639       rs753624869       rs753707908       rs753869477       rs753899626       rs753965926       rs754694535       rs755242294       rs755806671       rs755974428       rs755995272       rs756014514       rs756085881       rs756753837       rs757123395       rs757574552       rs757979861       rs759525840       rs759548501       rs759937600       rs759974754       rs760921163       rs761378476       rs761551054       rs761756652       rs761808047       rs761823135       rs761998404       rs762411162       rs762612349       rs762921249       rs763144027       rs763166362       rs763251035       rs763380575       rs763849982       rs763914345       rs764133118       rs764239488       rs764327213       rs764612174       rs765190153       rs765208571       rs765409769       rs766344202       rs766371396       rs766626073       rs766926821       rs767083663       rs767101992       rs767306139       rs768303626       rs768423281       rs768575083       rs768807826       rs769150907       rs769262568       rs769400771       rs770198147       rs770519689       rs771209397       rs771494831       rs771589730       rs771749165       rs771994713       rs772101792       rs772361828       rs772555991       rs772892943       rs772979938       rs773358366       rs773737295       rs773984856       rs773988947       rs774033990       rs774510939       rs774594128       rs775131526       rs775151824       rs775284197       rs775604132       rs775735722       rs775823318       rs775936067       rs776385392       rs776844373       rs777069787       rs777080024       rs777157503       rs777341385       rs777895796       rs778002742       rs778086851       rs778179268       rs778494193       rs778821585       rs778932906       rs779150519       rs779256274       rs779348086       rs779902969       rs779970425       rs779999777       rs780276267       rs780497389       rs780656686       rs780967341       rs781044648       rs781055164      

基因表达

基因表达

IFNL3基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
ACATAGCCCAGTTCAAGTCC
59
GAAGCGACTCTTCTAAGGCA
59
ACATAGCCCAGTTCAAGTC
57
GAAGCGACTCTTCTAAGGC
58
CACATAGCCCAGTTCAAGTC
58
AAGCGACTCTTCTAAGGCA
58
GAAACTAGACATGACCGGG
58
CTTGAACTGGGCTATGTGG
58
GAAACTAGACATGACCGGG
58
ACTTGAACTGGGCTATGTG
58
TGAAACTAGACATGACCGGG
60
GACTTGAACTGGGCTATGTG
59
ACATAGCCCAGTTCAAGTC
57
GAAGCGACTCTTCTAAGGC
58
ACATAGCCCAGTTCAAGTCC
60
GAAGCGACTCTTCTAAGGCA
60
CACATAGCCCAGTTCAAGTC
59
AAGCGACTCTTCTAAGGCA
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

IFNL3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

IFNL3基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005125
A0A0C4DGW8(UniProtKB)
IEA
GO:0005622
A0A0C4DGW8(UniProtKB)
IEA
GO:0007259
A0A0C4DGW8(UniProtKB)
IEA
GO:0050778
A0A0C4DGW8(UniProtKB)
IEA
GO:0051607
A0A0C4DGW8(UniProtKB)
IEA
GO:0005102
Q8IZI9(UniProtKB)
IBA
GO:0005125
Q8IZI9(UniProtKB)
IEA
GO:0005576
Q8IZI9(UniProtKB)
TAS
GO:0005615
Q8IZI9(UniProtKB)
IBA
GO:0005622
Q8IZI9(UniProtKB)
IEA
GO:0007259
Q8IZI9(UniProtKB)
IEA
GO:0045071
Q8IZI9(UniProtKB)
ISS
GO:0045087
Q8IZI9(UniProtKB)
IBA
GO:0050778
Q8IZI9(UniProtKB)
IEA
GO:0050863
Q8IZI9(UniProtKB)
IBA
GO:0051607
Q8IZI9(UniProtKB)
ISS
GO:0051607
Q8IZI9(UniProtKB)
IBA
GO:1903955
Q8IZI9(UniProtKB)
IMP

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控IFNL3基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Hepatitis C 0.22048837 287 14 BeFree_CTD_human_GAD
Asthma 0.120271442 2 0 BeFree_CTD_human
Dermatitis, Atopic 0.12 1 0 CTD_human
Food Allergy 0.12 1 0 CTD_human
Squamous cell carcinoma of the head and neck 0.12 1 0 CTD_human
HEPATITIS C VIRUS, SUSCEPTIBILITY TO 0.12 0 0 ORPHANET
Hepatitis C, Chronic 0.094842967 188 9 BeFree_GAD
HIV Infections 0.032584294 62 5 BeFree_GAD
Virus Diseases 0.009500466 35 2 BeFree
Hepatitis B 0.008957582 33 9 BeFree
Liver Cirrhosis 0.008338753 23 2 BeFree_GAD
Fibrosis, Liver 0.007600372 28 6 BeFree
Liver carcinoma 0.005971721 22 4 BeFree
Cirrhosis 0.005157396 19 2 BeFree
Hepatitis B, Chronic 0.004885954 18 3 BeFree
Icterus 0.004734064 2 1 GAD
Acute hepatitis C 0.003257302 12 1 BeFree
Anemia 0.002985861 11 2 BeFree
Fatty Liver 0.002714419 10 3 BeFree
Liver diseases 0.002442977 9 2 BeFree
Coinfection 0.002171535 8 4 BeFree
Steatohepatitis 0.002171535 8 3 BeFree
Hepatitis A 0.001628651 6 1 BeFree
Hepatitis, Chronic 0.001628651 6 1 BeFree
Diabetes Mellitus 0.001357209 5 1 BeFree
Hepatitis 0.001357209 5 1 BeFree
Cytomegalovirus Infections 0.001085767 4 0 BeFree
Diabetes 0.001085767 4 1 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.000814326 3 2 BeFree
Tropical Spastic Paraparesis 0.000814326 3 2 BeFree
Non-alcoholic Fatty Liver Disease 0.000814326 3 1 BeFree
Hepatocarcinogenesis 0.000814326 3 0 BeFree
Cooley's anemia 0.000542884 2 0 BeFree
Adult T-Cell Lymphoma/Leukemia 0.000542884 2 1 BeFree
Viral hepatitis 0.000542884 2 0 BeFree
Vitamin D Deficiency 0.000542884 2 1 BeFree
Chronic viral hepatitis 0.000542884 2 1 BeFree
Chronic liver disease 0.000542884 2 1 BeFree
Mixed cryoglobulinemia 0.000542884 2 0 BeFree
Primary infection NOS 0.000542884 2 0 BeFree
beta Thalassemia 0.000271442 1 0 BeFree
Cryoglobulinemia 0.000271442 1 5 BeFree
Hepatitis D Infection 0.000271442 1 0 BeFree
Tick-Borne Encephalitis 0.000271442 1 0 BeFree
Esophageal Varices 0.000271442 1 0 BeFree
Foot-and-Mouth Disease 0.000271442 1 0 BeFree
Hemophilia A 0.000271442 1 1 BeFree
Herpes Simplex Infections 0.000271442 1 0 BeFree
Influenza 0.000271442 1 0 BeFree
Macular degeneration 0.000271442 1 0 BeFree
Meningitis 0.000271442 1 0 BeFree
Meningoencephalitis 0.000271442 1 0 BeFree
Metabolic Diseases 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
Retinal Diseases 0.000271442 1 0 BeFree
Retinitis 0.000271442 1 1 BeFree
RNA Virus Infections 0.000271442 1 0 BeFree
Thalassemia 0.000271442 1 0 BeFree
Alcohol abuse 0.000271442 1 0 BeFree
Cholestatic hepatitis 0.000271442 1 0 BeFree
Cytomegalovirus Retinitis 0.000271442 1 0 BeFree
Dyslipidemias 0.000271442 1 0 BeFree
Age related macular degeneration 0.000271442 1 0 BeFree
Prediabetes syndrome 0.000271442 1 1 BeFree
Hepatitis D, Chronic 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
Biliary stricture 0.000271442 1 0 BeFree
Hemophilia, NOS 0.000271442 1 1 BeFree
Hepatitis, Drug-Induced 0.000271442 1 0 BeFree
Hepatitis C Virus-Related Hepatocellular Carcinoma 0.000271442 1 0 BeFree
Allergic disposition 0.000271442 1 1 BeFree
Infection in children 0.000271442 1 0 BeFree

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