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This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
[中文简述(自动翻译):]  这个基因编码属于七跨膜G蛋白偶联型受体蛋白家族的一个蛋白质。与GSα亚基编码的蛋白质夫妇和刺激腺苷酸环化酶激活环AMP依赖性信号传导途径。这种受体被认为是调节大脑中的神经元胆碱能传输。一些抗抑郁药和抗精神病药物对这种受体具有高亲和力。 [由RefSeq的,2013年8月提供]
HTR6基因(以及对应的蛋白质)的细胞分布位置:
HTR6基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Schizophrenia | 0.139912403 | 16 | 0 | BeFree_CTD_human_GAD_LHGDN |
| Memory Disorders | 0.12 | 1 | 0 | CTD_human |
| Psychoses, Substance-Induced | 0.12 | 1 | 0 | CTD_human |
| Amphetamine-Related Disorders | 0.12 | 1 | 0 | CTD_human |
| Alzheimer's Disease | 0.012649486 | 6 | 0 | BeFree_GAD |
| Parkinson Disease | 0.005091382 | 1 | 0 | GAD_LHGDN |
| Mental Depression | 0.005005506 | 3 | 1 | BeFree_GAD |
| Personality Traits | 0.004734064 | 2 | 0 | GAD |
| Major Depressive Disorder | 0.003181358 | 4 | 1 | BeFree_GAD |
| Mood Disorders | 0.002909916 | 2 | 1 | BeFree_GAD |
| Autistic Disorder | 0.002367032 | 1 | 0 | GAD |
| Fatigue | 0.002367032 | 1 | 0 | GAD |
| Chronic Fatigue Syndrome | 0.002367032 | 1 | 0 | GAD |
| Personality Disorders | 0.002367032 | 1 | 0 | GAD |
| Weight Gain | 0.002367032 | 1 | 0 | GAD |
| Migraine Disorders | 0.002367032 | 1 | 0 | GAD |
| Weight Gain Adverse Event | 0.002367032 | 1 | 0 | GAD |
| Unipolar Depression | 0.000814326 | 3 | 1 | BeFree |
| Presenile dementia | 0.000542884 | 2 | 1 | BeFree |
| Dementia | 0.000542884 | 2 | 1 | BeFree |
| Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
| Delusions | 0.000271442 | 1 | 1 | BeFree |
| Hallucinations | 0.000271442 | 1 | 1 | BeFree |
| Lingual-Facial-Buccal Dyskinesia | 0.000271442 | 1 | 1 | BeFree |
| Tardive Dyskinesia | 0.000271442 | 1 | 1 | BeFree |
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