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This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]
[中文简述(自动翻译):]  该基因编码伴侣蛋白家族的一个成员。所编码的线粒体蛋白可以作为在先天免疫系统的信号分子起作用。这种蛋白是在线粒体中新导入的蛋白质的折叠和装配的关键。这种基因是邻近于相关家族成员和一个双向启动子的2个基因的功能之间的区域。一些假已与这个基因有关。编码相同蛋白质的两个转录物的变体已被确定为这个基因。这种基因常染色体事业相关的基因突变隐性痉挛性截瘫13通过的RefSeq,2010年6月提供]
HSPD1基因(以及对应的蛋白质)的细胞分布位置:
HSPD1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Spastic paraplegia 13, autosomal dominant | 0.56 | 1 | 1 | CLINVAR_CTD_human_MGD_ORPHANET_UNIPROT |
| Leukodystrophy, Hypomyelinating, 4 | 0.480542884 | 3 | 1 | BeFree_CLINVAR_CTD_human_ORPHANET_UNIPROT |
| Endotoxemia | 0.2 | 2 | 0 | CTD_human_RGD |
| HIV Infections | 0.120814326 | 4 | 0 | BeFree_CTD_human |
| Adenocarcinoma | 0.120542884 | 3 | 0 | BeFree_CTD_human |
| Acute Coronary Syndrome | 0.120542884 | 3 | 0 | BeFree_CTD_human |
| Renal Cell Carcinoma | 0.12 | 1 | 0 | CTD_human |
| Hypertrophic Cardiomyopathy | 0.12 | 1 | 0 | CTD_human |
| Stomach Neoplasms | 0.12 | 2 | 0 | CTD_human |
| Infarction, Middle Cerebral Artery | 0.12 | 1 | 0 | CTD_human |
| Cardiomyopathies | 0.12 | 1 | 0 | CTD_human |
| Sepsis | 0.083267234 | 4 | 0 | BeFree_LHGDN_RGD |
| Alzheimer's Disease | 0.082367032 | 2 | 0 | GAD_RGD |
| Hypertensive disease | 0.080271442 | 3 | 0 | BeFree_RGD |
| Anoxia | 0.08 | 1 | 0 | RGD |
| Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
| Hemorrhage | 0.08 | 1 | 0 | RGD |
| Hydrocephalus | 0.08 | 1 | 0 | RGD |
| Hyperglycemia | 0.08 | 1 | 0 | RGD |
| Insulin Resistance | 0.08 | 1 | 0 | RGD |
| Myocardial Infarction | 0.08 | 1 | 0 | RGD |
| Parkinson Disease | 0.08 | 1 | 0 | RGD |
| Subarachnoid Hemorrhage | 0.08 | 1 | 0 | RGD |
| Varicocele | 0.08 | 1 | 0 | RGD |
| Myocardial Ischemia | 0.08 | 1 | 0 | RGD |
| Arthritis, Experimental | 0.08 | 1 | 0 | RGD |
| Coronary heart disease | 0.008815624 | 7 | 0 | BeFree_GAD_LHGDN |
| Arthritis | 0.00680591 | 7 | 0 | BeFree_LHGDN |
| Atherosclerosis | 0.006795978 | 15 | 0 | BeFree_LHGDN |
| Prostatic Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
| Tuberculosis | 0.005428837 | 20 | 0 | BeFree |
| Diabetes Mellitus | 0.004267125 | 8 | 0 | BeFree_GAD |
| Autoimmune Diseases | 0.00408156 | 6 | 0 | BeFree_LHGDN |
| Spastic Paraplegia, Hereditary | 0.00408156 | 5 | 1 | BeFree_LHGDN |
| Arteriosclerosis | 0.004071628 | 15 | 0 | BeFree |
| Rheumatoid Arthritis | 0.003724241 | 5 | 0 | BeFree_GAD |
| Cardiovascular Diseases | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Hepatitis B | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Lyme Disease | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Neoplasm Metastasis | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Coronary Artery Disease | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Down Syndrome | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Neurodegenerative Disorders | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Liver carcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Atrial Fibrillation | 0.00272435 | 1 | 0 | LHGDN |
| Carotid Artery Diseases | 0.00272435 | 1 | 0 | LHGDN |
| Dermatomyositis | 0.00272435 | 1 | 0 | LHGDN |
| Inflammation | 0.00272435 | 1 | 0 | LHGDN |
| Schizophrenia | 0.00272435 | 1 | 0 | LHGDN |
| Septic Shock | 0.00272435 | 1 | 0 | LHGDN |
| Paraparesis, Spastic | 0.00272435 | 1 | 0 | LHGDN |
| Tic disorder | 0.00272435 | 1 | 0 | LHGDN |
| Prion Diseases | 0.00272435 | 1 | 0 | LHGDN |
| Infection | 0.00272435 | 1 | 0 | LHGDN |
| Spastic paralysis | 0.002367032 | 1 | 0 | GAD |
| Diabetes | 0.001900093 | 7 | 0 | BeFree |
| Ovarian Carcinoma | 0.001628651 | 6 | 0 | BeFree |
| Arthritis, Adjuvant-Induced | 0.001357209 | 5 | 0 | BeFree |
| Leprosy | 0.001357209 | 5 | 0 | BeFree |
| Mycobacterium avium-intracellulare Infection | 0.001357209 | 5 | 0 | BeFree |
| Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.001357209 | 5 | 0 | BeFree |
| Infectious disease of lung | 0.001357209 | 5 | 0 | BeFree |
| Diabetes Mellitus, Insulin-Dependent | 0.001085767 | 4 | 0 | BeFree |
| Mycobacterium Infections | 0.001085767 | 4 | 0 | BeFree |
| Ankylosing spondylitis | 0.001085767 | 4 | 0 | BeFree |
| Carcinogenesis | 0.001085767 | 4 | 0 | BeFree |
| Helicobacter pylori infection | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.001085767 | 4 | 0 | BeFree |
| Juvenile arthritis | 0.001085767 | 4 | 0 | BeFree |
| Juvenile rheumatoid arthritis | 0.001085767 | 4 | 0 | BeFree |
| Behcet Syndrome | 0.000814326 | 3 | 0 | BeFree |
| Coronary Arteriosclerosis | 0.000814326 | 3 | 0 | BeFree |
| Mucocutaneous Lymph Node Syndrome | 0.000814326 | 3 | 0 | BeFree |
| Arthritis, Reactive | 0.000814326 | 3 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000814326 | 3 | 0 | BeFree |
| Angina, Unstable | 0.000542884 | 2 | 0 | BeFree |
| Primary biliary cirrhosis | 0.000542884 | 2 | 0 | BeFree |
| Ulcerative Colitis | 0.000542884 | 2 | 0 | BeFree |
| Cystic Fibrosis | 0.000542884 | 2 | 0 | BeFree |
| Filarial Elephantiases | 0.000542884 | 2 | 0 | BeFree |
| Gastritis | 0.000542884 | 2 | 0 | BeFree |
| Gingival Diseases | 0.000542884 | 2 | 0 | BeFree |
| Ischemia | 0.000542884 | 2 | 0 | BeFree |
| Tuberculoid leprosy | 0.000542884 | 2 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
| Melioidosis | 0.000542884 | 2 | 0 | BeFree |
| Obesity | 0.000542884 | 2 | 0 | BeFree |
| Periodontal Diseases | 0.000542884 | 2 | 0 | BeFree |
| Periodontitis | 0.000542884 | 2 | 0 | BeFree |
| Septicemia | 0.000542884 | 2 | 0 | BeFree |
| Spastic Paraplegia | 0.000542884 | 2 | 0 | BeFree |
| Tetanus | 0.000542884 | 2 | 0 | BeFree |
| Intestinal Volvulus | 0.000542884 | 2 | 0 | BeFree |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| infertility tubal factor | 0.000542884 | 2 | 0 | BeFree |
| Arthritis, Collagen-Induced | 0.000542884 | 2 | 0 | BeFree |
| Abscess | 0.000271442 | 1 | 0 | BeFree |
| Acne Vulgaris | 0.000271442 | 1 | 0 | BeFree |
| Aortic Valve Stenosis | 0.000271442 | 1 | 0 | BeFree |
| Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Cat-Scratch Disease | 0.000271442 | 1 | 0 | BeFree |
| Celiac Disease | 0.000271442 | 1 | 0 | BeFree |
| Chancroids | 0.000271442 | 1 | 0 | BeFree |
| Chlamydia Infections | 0.000271442 | 1 | 0 | BeFree |
| Colitis | 0.000271442 | 1 | 0 | BeFree |
| Dengue Fever | 0.000271442 | 1 | 0 | BeFree |
| Endocarditis | 0.000271442 | 1 | 0 | BeFree |
| Gingivitis | 0.000271442 | 1 | 0 | BeFree |
| Herpes Simplex Infections | 0.000271442 | 1 | 0 | BeFree |
| Immune System Diseases | 0.000271442 | 1 | 0 | BeFree |
| Influenza | 0.000271442 | 1 | 0 | BeFree |
| Leukodystrophy | 0.000271442 | 1 | 0 | BeFree |
| Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
| Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
| Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Nocardia Infections | 0.000271442 | 1 | 0 | BeFree |
| Pneumonia | 0.000271442 | 1 | 0 | BeFree |
| Scrub Typhus | 0.000271442 | 1 | 0 | BeFree |
| Sexually Transmitted Diseases | 0.000271442 | 1 | 0 | BeFree |
| Sudden infant death syndrome | 0.000271442 | 1 | 0 | BeFree |
| Chagas Disease | 0.000271442 | 1 | 0 | BeFree |
| Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
| Bacterial Vaginosis | 0.000271442 | 1 | 0 | BeFree |
| Genital ulceration | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of gallbladder | 0.000271442 | 1 | 0 | BeFree |
| Aortic Aneurysm, Abdominal | 0.000271442 | 1 | 0 | BeFree |
| Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant ascites | 0.000271442 | 1 | 0 | BeFree |
| Gallbladder Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Pelvic Inflammatory Disease | 0.000271442 | 1 | 0 | BeFree |
| Infectious gastroenteritis | 0.000271442 | 1 | 0 | BeFree |
| Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
| Solid tumour | 0.000271442 | 1 | 0 | BeFree |
| MRSA - Methicillin resistant Staphylococcus aureus infection | 0.000271442 | 1 | 0 | BeFree |
| Diffuse lepromatous leprosy | 0.000271442 | 1 | 0 | BeFree |
| Fetal Hypoxia | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Aortic valve calcification | 0.000271442 | 1 | 0 | BeFree |
| Human anaplasmosis due to Anaplasma phagocytophilum | 0.000271442 | 1 | 0 | BeFree |
| Oropharynx (excludes nasopharynx) | 0.000271442 | 1 | 0 | BeFree |
| Oropharyngeal disorders | 0.000271442 | 1 | 0 | BeFree |
| Minor oral aphthous ulceration | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
| Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Acne | 0.000271442 | 1 | 0 | BeFree |
| Advanced cancer | 0.000271442 | 1 | 0 | BeFree |
| Mitochondrial Respiratory Chain Deficiencies | 0.000271442 | 1 | 0 | BeFree |
| Chlamydia pneumoniae infection | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
| Epithelioma | 0.000271442 | 1 | 0 | BeFree |
| Tumor Immunity | 0.000271442 | 1 | 0 | BeFree |
| Non-Malignant Ascites Adverse Event | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory acne | 0.000271442 | 1 | 0 | BeFree |
| Reproductive tract infection | 0.000271442 | 1 | 0 | BeFree |
| Recurrent aphthous ulcer | 0.000271442 | 1 | 0 | BeFree |
| Allergic disposition | 0.000271442 | 1 | 0 | BeFree |
| AORTIC VALVE DISEASE 2 | 0.000271442 | 1 | 0 | BeFree |
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