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Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
[中文简述(自动翻译):]  休止/β-类休止蛋白家族的成员被认为参与G蛋白偶联受体的激动剂介导的脱敏而导致的细胞应答特异性衰减到刺激如激素,神经递质,或感觉信号。休止Beta 1的是一个胞浆蛋白和充当β-肾上腺能受体的β-肾上腺素能受体激酶(树皮)介导的脱敏的辅助因子。除了中枢神经系统,这是在高的水平在外周血白细胞中表达,并且因此树皮/β-类休止系统被认为在调节受体介导的免疫功能的重要作用。编码休止测试1的不同同种型的可变剪接转录物已有描述。 [由RefSeq的,2011年1月提供]
ARRB1基因(以及对应的蛋白质)的细胞分布位置:
ARRB1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Heart failure | 0.080271442 | 2 | 0 | BeFree_RGD |
| Arthritis, Experimental | 0.080271442 | 2 | 0 | BeFree_RGD |
| Arteriovenous fistula | 0.08 | 1 | 0 | RGD |
| Colitis | 0.08 | 1 | 0 | RGD |
| Nicotine Dependence | 0.002638474 | 1 | 0 | BeFree_GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Neoplasm Metastasis | 0.000814326 | 3 | 0 | BeFree |
| Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000814326 | 3 | 0 | BeFree |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| Acromegaly | 0.000271442 | 1 | 0 | BeFree |
| Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Glioma | 0.000271442 | 1 | 0 | BeFree |
| Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
| Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Mild Mental Retardation | 0.000271442 | 1 | 0 | BeFree |
| Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Arthritis, Collagen-Induced | 0.000271442 | 1 | 0 | BeFree |
| Tumor Angiogenesis | 0.000271442 | 1 | 0 | BeFree |
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