ARRB1 (arrestin beta 1)

基因基本信息

基因基本信息

symbol:
ARRB1
locus group:
protein-coding gene
location:
11q13.4
gene_family:
alias symbol:
None
alias name:
arrestin 2
entrez id:
408
ensembl gene id:
ENSG00000137486
ucsc gene id:
uc001owf.3
refseq accession:
NM_004041
hgnc_id:
HGNC:711
approved reserved:
1994-01-10

基因染色体位置

基因染色体位置

11q13.4
基因染色体位置图

基因简述

基因简述

ARRB1（β-arrestin 1）属于arrestin基因家族，该家族还包括ARRB2（β-arrestin 2）、视觉arrestin（SAG）和cone arrestin（ARR3）。arrestin家族蛋白的共同特点是能够与激活的G蛋白偶联受体（GPCR）结合，介导受体内化和信号脱敏，从而调控GPCR信号通路的强度和持续时间。ARRB1在多种组织中广泛表达，尤其在脑、心脏和免疫系统中发挥重要作用。它不仅参与GPCR信号调控，还作为支架蛋白介导非GPCR信号通路（如MAPK、AKT等），影响细胞增殖、迁移和凋亡等过程。ARRB1的主要作用位点包括细胞膜、内体和细胞核，通过与不同蛋白相互作用参与多种生物学功能。ARRB1突变可能导致GPCR信号失调，与多种疾病相关，如癌症（乳腺癌、肺癌等）、心血管疾病（心力衰竭、高血压）和神经系统疾病（帕金森病、精神分裂症）。ARRB1过表达可能增强受体脱敏并抑制GPCR信号，导致某些信号通路（如β肾上腺素受体通路）功能减弱，影响心脏功能或代谢调节；同时可能通过激活非GPCR通路（如Wnt/β-catenin）促进肿瘤发生。ARRB1表达降低则可能导致GPCR信号过度激活，与炎症反应增强、过敏性疾病和某些癌症进展相关。ARRB1还参与免疫调节，其表达变化可能影响T细胞功能和自身免疫疾病发展。在基因家族中，ARRB1和ARRB2功能高度相似但存在组织分布和底物偏好差异，例如ARRB1更倾向于与某些趋化因子受体结合。

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

休止/β-类休止蛋白家族的成员被认为参与G蛋白偶联受体的激动剂介导的脱敏而导致的细胞应答特异性衰减到刺激如激素，神经递质，或感觉信号。休止Beta 1的是一个胞浆蛋白和充当β-肾上腺能受体的β-肾上腺素能受体激酶（树皮）介导的脱敏的辅助因子。除了中枢神经系统，这是在高的水平在外周血白细胞中表达，并且因此树皮/β-类休止系统被认为在调节受体介导的免疫功能的重要作用。编码休止测试1的不同同种型的可变剪接转录物已有描述。 [由RefSeq的，2011年1月提供]

OMIM数据库中对ARRB1基因的介绍     Wikipedia数据库中对ARRB1基因的介绍

基因序列

基因序列

ARRB1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

ARRB1基因的碱基突变：           仅显示部分snp
rs3139       rs472112       rs475476       rs475557       rs476364       rs477750       rs480174       rs489161       rs490528       rs494146       rs494647       rs495193       rs495615       rs495938       rs498846       rs499332       rs501372      

基因表达

基因表达

ARRB1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CTCTAGCACCCTGTTGAGG
59
TGCAAGATCTCCCAACAGG
59
AAAGAGCGGAGAGTCTATGTG
59
GTACGTTGGCCACAAACAG
59
GAAGAGGCTGATGACACTG
58
TCTCGGTTATTGGCTAGGA
57
CTTTGTGGACCACATCGAC
58
GTCACATAGACTCTCCGCT
58
CATGTTCTGTGACACTGCAG
59
CTTCATAGTCCACACCGCA
59
AAGAGCGGAGAGTCTATGTG
59
GTACGTTGGCCACAAACAG
59
CTTTGTGGACCACATCGAC
58
GTCACATAGACTCTCCGCTC
59
CCTCTAGCACCCTGTTGAG
59
CCACCAGCTTCACTTTCAC
59
CATGTTCTGTGACACTGCA
58
CTTCATAGTCCACACCGCA
59
TGGAAGAGGCTGATGACAC
59
TCGGTTATTGGCTAGGAAGG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

ARRB1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

ARRB1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0007165
E9PM35 (UniProtKB)
IEA
GO:0007165
H0YET9 (UniProtKB)
IEA
GO:0000139
P49407 (UniProtKB)
TAS
GO:0000139
P49407 (UniProtKB)
TAS
GO:0000139
P49407 (UniProtKB)
TAS
GO:0000139
P49407 (UniProtKB)
TAS
GO:0000139
P49407 (UniProtKB)
TAS
GO:0000139
P49407 (UniProtKB)
TAS
GO:0000187
P49407 (UniProtKB)
IEA
GO:0000785
P49407 (UniProtKB)
IDA
GO:0001934
P49407 (UniProtKB)
IMP
GO:0002031
P49407 (UniProtKB)
IMP
GO:0002031
P49407 (UniProtKB)
IMP
GO:0002092
P49407 (UniProtKB)
IMP
GO:0004857
P49407 (UniProtKB)
TAS
GO:0005096
P49407 (UniProtKB)
IMP
GO:0005159
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005515
P49407 (UniProtKB)
IPI
GO:0005634
P49407 (UniProtKB)
IDA
GO:0005654
P49407 (UniProtKB)
IDA
GO:0005737
P49407 (UniProtKB)
IDA
GO:0005737
P49407 (UniProtKB)
IDA
GO:0005737
P49407 (UniProtKB)
IDA
GO:0005765
P49407 (UniProtKB)
TAS
GO:0005765
P49407 (UniProtKB)
TAS
GO:0005829
P49407 (UniProtKB)
TAS
GO:0005829
P49407 (UniProtKB)
TAS
GO:0005829
P49407 (UniProtKB)
TAS
GO:0005829
P49407 (UniProtKB)
TAS
GO:0005829
P49407 (UniProtKB)
TAS
GO:0005829
P49407 (UniProtKB)
TAS
GO:0005829
P49407 (UniProtKB)
TAS
GO:0005829
P49407 (UniProtKB)
TAS
GO:0005829
P49407 (UniProtKB)
TAS
GO:0005886
P49407 (UniProtKB)
TAS
GO:0005905
P49407 (UniProtKB)
IEA
GO:0006366
P49407 (UniProtKB)
IMP
GO:0007602
P49407 (UniProtKB)
IEA
GO:0008134
P49407 (UniProtKB)
IPI
GO:0014069
P49407 (UniProtKB)
IEA
GO:0015031
P49407 (UniProtKB)
IEA
GO:0016323
P49407 (UniProtKB)
IEA
GO:0016567
P49407 (UniProtKB)
IMP
GO:0030168
P49407 (UniProtKB)
TAS
GO:0030331
P49407 (UniProtKB)
IEA
GO:0030659
P49407 (UniProtKB)
TAS
GO:0030659
P49407 (UniProtKB)
TAS
GO:0031143
P49407 (UniProtKB)
IEA
GO:0031397
P49407 (UniProtKB)
IDA
GO:0031398
P49407 (UniProtKB)
IEA
GO:0031410
P49407 (UniProtKB)
IDA
GO:0031434
P49407 (UniProtKB)
IEA
GO:0031625
P49407 (UniProtKB)
IPI
GO:0031691
P49407 (UniProtKB)
IEA
GO:0031692
P49407 (UniProtKB)
IEA
GO:0031701
P49407 (UniProtKB)
IPI
GO:0031762
P49407 (UniProtKB)
IEA
GO:0031896
P49407 (UniProtKB)
IEA
GO:0032088
P49407 (UniProtKB)
IDA
GO:0032092
P49407 (UniProtKB)
IEA
GO:0032715
P49407 (UniProtKB)
IDA
GO:0032717
P49407 (UniProtKB)
IDA
GO:0033138
P49407 (UniProtKB)
IEA
GO:0034260
P49407 (UniProtKB)
IEA
GO:0034393
P49407 (UniProtKB)
IEA
GO:0035025
P49407 (UniProtKB)
IMP
GO:0035066
P49407 (UniProtKB)
IMP
GO:0035612
P49407 (UniProtKB)
IEA
GO:0035615
P49407 (UniProtKB)
IEA
GO:0035774
P49407 (UniProtKB)
IEA
GO:0036276
P49407 (UniProtKB)
IEA
GO:0042699
P49407 (UniProtKB)
IEA
GO:0043027
P49407 (UniProtKB)
IEA
GO:0043149
P49407 (UniProtKB)
IMP
GO:0043154
P49407 (UniProtKB)
IEA
GO:0043161
P49407 (UniProtKB)
IMP
GO:0043197
P49407 (UniProtKB)
IEA
GO:0043280
P49407 (UniProtKB)
IEA
GO:0043547
P49407 (UniProtKB)
IEA
GO:0044212
P49407 (UniProtKB)
IMP
GO:0044325
P49407 (UniProtKB)
IEA
GO:0045211
P49407 (UniProtKB)
IEA
GO:0045309
P49407 (UniProtKB)
IEA
GO:0045944
P49407 (UniProtKB)
IMP
GO:0070373
P49407 (UniProtKB)
IEA
GO:0070374
P49407 (UniProtKB)
IDA
GO:0090240
P49407 (UniProtKB)
IMP
GO:0004402
P49407 (UniProtKB)
IDA
GO:0005834
P49407 (UniProtKB)
TAS

基因相关microRNA

基因相关microRNA

可能调控 ARRB1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Arthritis, Experimental 0.080271442 2 0 BeFree_RGD
Heart failure 0.080271442 2 0 BeFree_RGD
Colitis 0.08 1 0 RGD
Arteriovenous fistula 0.08 1 0 RGD
Nicotine Dependence 0.002638474 1 0 BeFree_GAD
Tobacco Use Disorder 0.002367032 1 0 GAD
Neoplasm Metastasis 0.000814326 3 0 BeFree
Ovarian Carcinoma 0.000814326 3 0 BeFree
Malignant neoplasm of ovary 0.000814326 3 0 BeFree
Non-Small Cell Lung Carcinoma 0.000814326 3 0 BeFree

基因相关服务

基因相关服务

联系方式

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