KRT5(keratin 5, type II) 转至新版数据库

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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12q13.13
基因染色体位置图

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  由该基因编码的蛋白质是角蛋白基因家族的一个成员。 II型角蛋白包括被布置成对简单和分层上皮组织分化过程中共同表达异型角蛋白链的碱性或中性的蛋白质。这种II型角蛋白是在表皮的家庭成员KRT14基底层特异性表达。在这些基因中的突变已与称为表皮松解单纯的疾病的复杂相关联。 II型角蛋白聚集在染色体12q12-Q13的一个区域。 [由RefSeq的,2008年7月提供]

KRT5基因的碱基序列:[NCBI]
KRT5基因的碱基突变:           显示全部snp
rs6603       rs89962       rs596453       rs607860       rs638907       rs639790       rs641615       rs641621       rs651487       rs907775       rs1065115       rs1065116       rs1132948       rs1799848       rs1799849       rs1799902       rs2280081       rs2292501       rs2361323       rs2669875       rs2669876       rs3741725       rs3759186       rs3759187       rs3759188       rs3847840       rs3888512       rs3888513       rs4761923       rs4761924       rs7315406       rs10531879       rs11170163       rs11170164       rs11549949       rs11549950       rs11549951      
rs11549959       rs11549960       rs12228527       rs12228533       rs12231130       rs12231139       rs12231141       rs12821071       rs12828043       rs17852231       rs28694819       rs34311965       rs55932286       rs57074404       rs57348201       rs57351762       rs57378129       rs58751565       rs58991262       rs59112594       rs59115483       rs59686386       rs59730172       rs59864957       rs60062350       rs60314569       rs60720877       rs60815939       rs61135810       rs61747180       rs61747181       rs61747182       rs61747188       rs61916869       rs62642056       rs73103299       rs73316383       rs73316386       rs73316388       rs73316389       rs73316391       rs73316392       rs73316396       rs73316399       rs73316401       rs73318304       rs73318305       rs73318306       rs73318309       rs73318314       rs74093460       rs74093471       rs74093478       rs74671930       rs74714082       rs75601424       rs75978253       rs76947550       rs77342953       rs77440541       rs77748304       rs78198419       rs79752942       rs111328754       rs111380066       rs111583423       rs111681226       rs111699669       rs111777032       rs112071268       rs112212911       rs112335188       rs112492143       rs112704653       rs112753883       rs113169113       rs113372209       rs113377855       rs113762818       rs113876905       rs113968361       rs113979715       rs114225611       rs114245582       rs114542805       rs114734812       rs115629601       rs116018903       rs116384359       rs116568080       rs116698689       rs116931869       rs117643747       rs121912476       rs137873304       rs138218183       rs138385158       rs138697843       rs138806570       rs139036685       rs139683621       rs139863285       rs140352947       rs140357507       rs140376577       rs140660135       rs140700488       rs140829014       rs141204432       rs141279000       rs141330791       rs141631999       rs142320369       rs142353537       rs142446757       rs142744029       rs142778320       rs142879390       rs143566042       rs143630653       rs143948093       rs144226740       rs144359915       rs144480716       rs144845827       rs144956252       rs145017901       rs145442570       rs145545676       rs145587149       rs146022149       rs146136560       rs146583344       rs146717935       rs147185753       rs147498164       rs148049379       rs148276250       rs148526538       rs148806544       rs149467228       rs149784665       rs149814225       rs149863112       rs150075005       rs150128589       rs150390099       rs150726879       rs151258734       rs151313162       rs181731504       rs181920047       rs182418666       rs182482982       rs182508044       rs183533103       rs184106066       rs184107171       rs185814423       rs185885605       rs186367281       rs186608084       rs187158201       rs188787376       rs189809740       rs189978925       rs190508502       rs191061409       rs191204713       rs191454627       rs191863441       rs191867115       rs199505033       rs199530956       rs199722905       rs199823765       rs199854656       rs200072843       rs200116437       rs200156424       rs200170666       rs200188533       rs200333163       rs200382856       rs200563006       rs200589093       rs200597314       rs200658792       rs200916228       rs201235054       rs201264698       rs201274668       rs201406573       rs201458850       rs201553490       rs201553621       rs201583229       rs201847147       rs201880061       rs202104381       rs202121015       rs202197926       rs267607443       rs267607448       rs267607452       rs267607657       rs367550024       rs367665298       rs367853808       rs367918420       rs367950934       rs368027956       rs368040858       rs368052476       rs368289265       rs368543262       rs368584130       rs368623188       rs368714959       rs368892761       rs369251535       rs369400727       rs369402814       rs369447745       rs369607474       rs369679157       rs370014907       rs370060795       rs370207477       rs370382888       rs370470978       rs370714132       rs370812116       rs370820008       rs371039401       rs371391512       rs371583070       rs371682500       rs371739329       rs371853143       rs371960977       rs372204272       rs372305341       rs372891278       rs373091255       rs373124656       rs373163099       rs373342539       rs373621203       rs373654288       rs373891687       rs373956161       rs374017172       rs374119094       rs374228362       rs374232804       rs374289543       rs374322915       rs374462183       rs374468864       rs374535811       rs374789712       rs374859036       rs375104646       rs375140289       rs375261078       rs375273687       rs375333850       rs375759050       rs375764474       rs376462752       rs376720840       rs377261145       rs377514553       rs377673721       rs377719362       rs528022026       rs528228263       rs528469166       rs529397720       rs529748202       rs529810527       rs529929497       rs529995841       rs530702699       rs530758856       rs530897727       rs531299414       rs533314803       rs533422741       rs534282270       rs534833753       rs534913364       rs536417351       rs536940345       rs537273071       rs537300208       rs537359928       rs537370039       rs537410587       rs537878340       rs537883207       rs537901731       rs538273779       rs539137273       rs539263098       rs539432563       rs539670470       rs539734770       rs540081758       rs540084813       rs540097325       rs540998719       rs541079880       rs541279700       rs541690939       rs541890896       rs541903408       rs541927296       rs541966565       rs542080086       rs543092277       rs543105226       rs543279922       rs543314808       rs543384101       rs543574061       rs543699099       rs543988182       rs544035489       rs544627684       rs545055407       rs545470281       rs545531634       rs545958947       rs546367749       rs546429164       rs547216197       rs547253765       rs547622442       rs548249521       rs548314067       rs548423593       rs549264510       rs549383569       rs549952624       rs550268995       rs550483827       rs551842938       rs551954313       rs552498995       rs552552191       rs552561992       rs552694552       rs552722009       rs552782093       rs553534642       rs553666316       rs553743213       rs553755257       rs553811973       rs555591733       rs556154141       rs556695887       rs556992218       rs557105004       rs557607337       rs558259285       rs558401339       rs558753839       rs558868908       rs558978871       rs559289143       rs559374065       rs559803373       rs559855807       rs559917786       rs559931389       rs560044234       rs560312488       rs560762795       rs560876071       rs561263847       rs561738497       rs562480319       rs562527249       rs564086904       rs565216518       rs565375836       rs565876404       rs565958149       rs566032276       rs566090157       rs566153067       rs566284589       rs567073912       rs567206131       rs568079890       rs568153857       rs568195279       rs568258080       rs568270124       rs568719663       rs568781979       rs569457446       rs569890901       rs570047391       rs570079009       rs570531194       rs570888765       rs571491531       rs571604097       rs572464702       rs572849401       rs573355962       rs573419701       rs573432072       rs573548957       rs573659998       rs573693529       rs574184835       rs574231718       rs574252564       rs574374329       rs574395658       rs574459815       rs575136636       rs575513919       rs575671208       rs576205316       rs576713878       rs576936247       rs577053577       rs577244472       rs577328983       rs577874190       rs745506216       rs745507253       rs745609596       rs745773711       rs745778115       rs745858077       rs745902310       rs745936095       rs745954253       rs746080330       rs746086734       rs746285968       rs746317574       rs746549590       rs746626191       rs746776082       rs746791048       rs746940114       rs747069497       rs747286504       rs747290107       rs747325105       rs747606382       rs747659373       rs747699437       rs747792410       rs748253152       rs748370126       rs748377756       rs748450223       rs748685194       rs748836260       rs748888461       rs749042087       rs749140215       rs749195594       rs749669264       rs749793889       rs749841907       rs749843921       rs750089477       rs750095810       rs750363093       rs750367973       rs750554604       rs750633567       rs750686005       rs750787121       rs750902479       rs751037633       rs751065772       rs751071388       rs751150862       rs751505210       rs751860679       rs751876144       rs751980183       rs751992720       rs752102397       rs752155719       rs752206118       rs752329142       rs752330859       rs752383934       rs752438760       rs752571765       rs752574978       rs752588410       rs752855887       rs753029185       rs753298083       rs753357425       rs753424487       rs753482540       rs753527599       rs753671394       rs753689113       rs753992833       rs754100299       rs754183095       rs754242209       rs754297557       rs754468001       rs754470005       rs754497740       rs754888747       rs754946912       rs754993022       rs755117771       rs755232621       rs755300932       rs755413229       rs755431715       rs755532805       rs755664811       rs755981320       rs756012140       rs756040984       rs756065835       rs756129437       rs756142099       rs756254239       rs756336643       rs756435108       rs756559586       rs756604202       rs756838467       rs757166763       rs757242079       rs757312484       rs757370875       rs757384415       rs757526192       rs757641925       rs757760193       rs757766724       rs757819698       rs757966253       rs757982689       rs758027626       rs758065668       rs758141613       rs758181003       rs758181958       rs758612631       rs758678109       rs758969808       rs759126352       rs759191256       rs759198073       rs759519803       rs759651620       rs759726325       rs759733947       rs759825894       rs759872510       rs760420480       rs760473690       rs760710214       rs760767549       rs760864383       rs760876234       rs761063555       rs761161855       rs761222342       rs761445270       rs761655080       rs761706455       rs761936382       rs761944980       rs761946940       rs761999937       rs762047842       rs762144950       rs762155109       rs762388603       rs762441018       rs762576590       rs762648653       rs762769877       rs762867625       rs762914663       rs763147225       rs763185384       rs763444328       rs763608512       rs763631335       rs763691214       rs763738111       rs763942830       rs764080871       rs764268730       rs764405894       rs764430671       rs764528228       rs764716641       rs764822595       rs764825902       rs764879342       rs765031976       rs765046732       rs765197461       rs765274259       rs765397274       rs765446846       rs765577850       rs765687033       rs765691429       rs765707603       rs765859104       rs766003980       rs766339802       rs766378801       rs766581787       rs766601150       rs766733036       rs766857995       rs766859647       rs767103163       rs767296169       rs767689296       rs767692987       rs767744479       rs767796043       rs767993231       rs768019473       rs768143674       rs768490522       rs768490644       rs768613443       rs768794468       rs768890570       rs768941859       rs769047092       rs769053414       rs769173374       rs769176692       rs769291559       rs769626917       rs769725141       rs769779953       rs769851449       rs769963375       rs770091254       rs770197901       rs770359543       rs770610430       rs770735188       rs770741540       rs770749113       rs770756355       rs770804108       rs770872825       rs770910564       rs770952740       rs771026976       rs771067613       rs771176935       rs771180057       rs771368861       rs771429075       rs771681325       rs771800180       rs772025669       rs772186106       rs772327428       rs772453159       rs772463154       rs772807927       rs772879789       rs772939737       rs773063966       rs773330348       rs773410009       rs773464963       rs773837847       rs774089332       rs774214749       rs774595910       rs774597887       rs774675868       rs774756410       rs774798876       rs774909388       rs775116551       rs775166393       rs775235203       rs775353075       rs775727503       rs775911175       rs776031981       rs776272199       rs776384768       rs776555128       rs776667863       rs776747513       rs776895650       rs776951107       rs777006944       rs777132336       rs777136785       rs777237775       rs777265572       rs777352718       rs777490729       rs777631293       rs777742041       rs777912551       rs778262903       rs778361402       rs778495257       rs778643234       rs778696476       rs778778095       rs778821833       rs778948719       rs779061940       rs779144030       rs779166505       rs779220016       rs779337038       rs779455758       rs779531180       rs779770273       rs779870641       rs779972193       rs780003015       rs780075629       rs780079242       rs780099328       rs780199576       rs780359251       rs780561152       rs780670406       rs780831978       rs780929128       rs781007379       rs781051765       rs781079778       rs781236556       rs781281556       rs781305886       rs781440465       rs781707438       rs781712315       rs781723954       rs797009160      

KRT5基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GAACAAGCCACCATGTCTC
59
GAAACCAAATCCACTACCGG
59
TTTGGGAGCTGTTAACCCT
59
GTGACAACAGAGATGTTGACTG
60
ATCCATCAGCACTAGTGGT
58
AAACCAAATCCACTACCGG
58
AGACCAAGTATGAGGAGCTG
59
TCTCAGAGATCTCATGCTTGG
59
GAACAAGCCACCATGTCTC
59
AAACCAAATCCACTACCGG
58
CTCATGAACACCAAGCTGG
59
CCACTGAGTCTGCATTCCT
59
GTTCTTTGATGCGGAGCTG
60
CTATCCAGGTCCAGGTTGC
60
GAAGACTTCAAGAACAAGTATGAGG
60
CACCTTGTTCATGTAGGCAG
59
TCTTCCCATTCAGAGGTGC
59
GATGTACTGCTCGAACAACG
59
CTGAAGAAGGATGTAGATGCTG
59
GTTAATCTCATCCATCAGTGCA
59
      尚未收录相关数据

KRT5基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

KRT5基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0005198
F8VU69(UniProtKB)
IEA
GO:0005882
F8VU69(UniProtKB)
IEA
GO:0005198
F8W0C6(UniProtKB)
IEA
GO:0045095
F8W0C6(UniProtKB)
IEA
GO:0005198
H0YI76(UniProtKB)
IEA
GO:0045095
H0YI76(UniProtKB)
IEA
GO:0005198
H0YIN9(UniProtKB)
IEA
GO:0045095
H0YIN9(UniProtKB)
IEA
GO:0005200
P13647(UniProtKB)
TAS
GO:0005515
P13647(UniProtKB)
IPI
GO:0005515
P13647(UniProtKB)
IPI
GO:0005515
P13647(UniProtKB)
IPI
GO:0005515
P13647(UniProtKB)
IPI
GO:0005515
P13647(UniProtKB)
IPI
GO:0005515
P13647(UniProtKB)
IPI
GO:0005515
P13647(UniProtKB)
IPI
GO:0005515
P13647(UniProtKB)
IPI
GO:0005634
P13647(UniProtKB)
IDA
GO:0005737
P13647(UniProtKB)
IDA
GO:0005739
P13647(UniProtKB)
IEA
GO:0005829
P13647(UniProtKB)
TAS
GO:0005882
P13647(UniProtKB)
IDA
GO:0005886
P13647(UniProtKB)
IEA
GO:0008544
P13647(UniProtKB)
TAS
GO:0016020
P13647(UniProtKB)
IDA
GO:0031581
P13647(UniProtKB)
TAS
GO:0045095
P13647(UniProtKB)
IDA
GO:0070062
P13647(UniProtKB)
IDA
GO:0097110
P13647(UniProtKB)
IPI
GO:0097110
P13647(UniProtKB)
IPI
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控KRT5基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Epidermolysis bullosa simplex with mottled pigmentation 0.482171535 8 1 BeFree_CLINVAR_CTD_human_ORPHANET_UNIPROT
Epidermolysis Bullosa Herpetiformis Dowling-Meara 0.44 9 9 CLINVAR_MGD_ORPHANET_UNIPROT
Weber-Cockayne Syndrome 0.361357209 15 16 BeFree_CLINVAR_ORPHANET_UNIPROT
Epidermolysis Bullosa Simplex with Migratory Circinate Erythema 0.360542884 2 2 BeFree_CLINVAR_CTD_human_ORPHANET
Epidermolysis Bullosa Simplex Kobner 0.360271442 8 11 BeFree_CLINVAR_ORPHANET_UNIPROT
dowling-degos disease 0.242985861 11 1 BeFree_CLINVAR_CTD_human
Basal cell carcinoma 0.242367032 3 1 CTD_human_GAD_GWASCAT
Epidermolysis Bullosa Simplex 0.15418532 58 9 BeFree_CTD_human_GAD_LHGDN
Neoplastic Cell Transformation 0.12 1 0 CTD_human
Adenoid Cystic Carcinoma 0.12 1 0 CTD_human
Animal Mammary Neoplasms 0.12 1 0 CTD_human
Mammary Neoplasms, Experimental 0.12 1 0 CTD_human
Salivary Gland Neoplasms 0.12 1 0 CTD_human
EPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE (disorder) 0.12 0 2 CLINVAR
Bladder Neoplasm 0.08 1 0 RGD
Squamous cell carcinoma 0.006448592 7 0 BeFree_GAD_LHGDN
Adenocarcinoma 0.006263026 5 0 BeFree_LHGDN
Malignant neoplasm of breast 0.003528744 13 0 BeFree
Epidermolysis Bullosa 0.003267234 3 0 BeFree_LHGDN
Mammary Neoplasms 0.002995792 2 0 BeFree_LHGDN
Skin Neoplasms 0.002909916 3 0 BeFree_GAD
Hyperplasia 0.00272435 1 0 LHGDN
Mesothelioma 0.00272435 1 0 LHGDN
Carcinoma, Lobular 0.00272435 1 0 LHGDN
Breast Carcinoma 0.002714419 10 0 BeFree
Cardiovascular Diseases 0.002367032 1 0 GAD
Brain Ischemia 0.002367032 1 0 GAD
Coronary heart disease 0.002367032 1 0 GAD
melanoma 0.002367032 1 0 GAD
Cerebrovascular accident 0.002367032 1 0 GAD
Coronary Artery Disease 0.002367032 1 0 GAD
Dermatologic disorders 0.001628651 6 0 BeFree
Neoplasm Metastasis 0.000814326 3 0 BeFree
Skin Diseases, Genetic 0.000814326 3 0 BeFree
Adrenocortical carcinoma 0.000814326 3 0 BeFree
Carcinogenesis 0.000814326 3 0 BeFree
Mottled pigmentation 0.000814326 3 3 BeFree
Noninfiltrating Intraductal Carcinoma 0.000542884 2 0 BeFree
Non-Small Cell Lung Carcinoma 0.000542884 2 0 BeFree
Glomerulonephritis, Membranoproliferative 0.000542884 2 0 BeFree
Malignant neoplasm of adrenal cortex 0.000542884 2 0 BeFree
Epidermolysis bullosa simplex herpetiformis 0.000542884 2 0 BeFree
Experimental Organism Basal Cell Carcinoma 0.000542884 2 1 BeFree
Malignant neoplasm of urinary bladder 0.000271442 1 0 BeFree
Brain Neoplasms 0.000271442 1 1 BeFree
Congenital chromosomal disease 0.000271442 1 0 BeFree
Immunologic Deficiency Syndromes 0.000271442 1 0 BeFree
Influenza 0.000271442 1 0 BeFree
Palmoplantar Keratosis 0.000271442 1 1 BeFree
Liver neoplasms 0.000271442 1 0 BeFree
Mycoplasma Infections 0.000271442 1 0 BeFree
Odontogenic Tumors 0.000271442 1 0 BeFree
Papilloma 0.000271442 1 0 BeFree
Precancerous Conditions 0.000271442 1 0 BeFree
Psoriasis 0.000271442 1 0 BeFree
Erythema 0.000271442 1 0 BeFree
Malignant neoplasm of mouth 0.000271442 1 0 BeFree
Adenosquamous carcinoma 0.000271442 1 0 BeFree
Verrucous carcinoma 0.000271442 1 0 BeFree
Lip and Oral Cavity Carcinoma 0.000271442 1 0 BeFree
Comedone 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Ichthyosis hystrix 0.000271442 1 1 BeFree
Superficial ulcer 0.000271442 1 0 BeFree
Triploidy syndrome 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Poikiloderma of Kindler 0.000271442 1 0 BeFree
Pigmentation Disorders 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree
Carcinoma of bladder 0.000271442 1 0 BeFree
Malignant Squamous Cell Neoplasm 0.000271442 1 0 BeFree
Breast adenocarcinoma 0.000271442 1 0 BeFree
Hyperkeratosis 0.000271442 1 0 BeFree
Squamous cell carcinoma of the head and neck 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree
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