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This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014]
[中文简述(自动翻译):]  该基因编码一个特定的淋巴解旋酶。其它解旋酶在涉及DNA链的分离,包括复制,修复,重组和转录过程起作用。这种蛋白质被认为参与与细胞增殖和白血病可能发挥作用。编码不同同种型的可变剪接转录物变体也已确定。 [由RefSeq的,2014年1月提供]
HELLS基因(以及对应的蛋白质)的细胞分布位置:
HELLS基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Polycystic Ovary Syndrome | 0.12 | 1 | 0 | CTD_human |
| Epithelial ovarian cancer | 0.002367032 | 1 | 0 | GAD |
| Squamous cell carcinoma of the head and neck | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
| Mycosis Fungoides | 0.000271442 | 1 | 0 | BeFree |
| Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
| Sezary Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Invasive Ductal Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant Conversion | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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