TPSD1(tryptase delta 1) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

16p13.3
基因染色体位置图

基因简述

基因简述

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  Tryptases包括家庭胰蛋白酶样丝氨酸蛋白酶，肽酶家族S1的。 Tryptases是酶促活性仅作为肝素稳定的四聚体，以及它们对所有已知的内源性蛋白酶抑制剂有抗性。几类胰蛋白酶基因聚集于染色体16p13.3。这些基因是由若干不同的功能特征。它们具有高度保守的3‘端非编码区，并含有串联重复序列在5‘侧翼和3‘非编码区这被认为在mRNA稳定性的调控中发挥作用。虽然该基因可能是个例外，大部分的类胰蛋白酶的基因具有内含子紧接在引发剂蛋氨酸密码子，该分离转录起始的从蛋白质编码序列中的位点的上游。此功能tryptases的特性，而且是不寻常的其他基因。 Tryptases有牵连如哮喘等过敏性和炎性疾病的发病机理调解器。该基因被一度被认为是假基因，虽然现在认为是编码的蛋白质的功能性基因。 [由RefSeq的，2008年7月提供]

OMIM数据库中对TPSD1基因的介绍     Wikipedia数据库中对TPSD1基因的介绍

基因序列

基因序列

TPSD1基因的碱基序列：[NCBI]

基因突变

基因突变

TPSD1基因的碱基突变：           显示全部snp
rs1060282       rs1064772       rs1141966       rs1141967       rs1800984       rs1969652       rs1969653       rs2003630       rs2005937       rs2092385       rs2242600       rs2272971       rs2401930       rs2401931       rs2401932       rs2401934       rs2401936       rs2401937       rs2401938       rs2401939       rs2401940       rs2401943       rs2401944       rs2401945       rs2974838       rs2982415       rs2982416       rs3830782       rs3865205       rs3874640       rs3895164       rs3927397       rs3957993       rs3993979       rs3993983       rs3993984       rs3993985      
rs3993988       rs4984785       rs11863069       rs12185152       rs12185155       rs12917724       rs13331887       rs13336924       rs28546647       rs28551132       rs34278105       rs35116045       rs35646486       rs61130540       rs61729108       rs61729110       rs61729111       rs61739908       rs61742230       rs61753433       rs61753447       rs71380255       rs71388244       rs72775466       rs72775467       rs74470113       rs74981201       rs76478181       rs78324915       rs79166520       rs79208293       rs79313952       rs79429608       rs79472859       rs111508742       rs112308680       rs113045458       rs113112799       rs113256300       rs113333718       rs113479771       rs114203903       rs114385573       rs115125936       rs115747642       rs115951186       rs116162996       rs116528198       rs116578041       rs116664309       rs117939610       rs138581914       rs139066040       rs139077060       rs139665939       rs139709116       rs139758820       rs139808778       rs139855296       rs140549361       rs141442396       rs141781532       rs142635848       rs142998820       rs143309290       rs143366031       rs143814068       rs143852280       rs143890672       rs143983677       rs143993373       rs144003164       rs145789356       rs145927179       rs146265703       rs146352730       rs147268885       rs148119827       rs148323184       rs148664529       rs148987137       rs149185735       rs150051915       rs150116875       rs150298197       rs151005068       rs151113266       rs181306162       rs181817058       rs181825594       rs183871785       rs185275637       rs186894479       rs188099297       rs189428938       rs189581184       rs189823657       rs190962014       rs199666513       rs199828554       rs199928926       rs199943898       rs199972980       rs200243725       rs200294439       rs200540687       rs200563281       rs200938484       rs200995228       rs201163591       rs201223052       rs201368920       rs201494832       rs201533114       rs201543585       rs201637610       rs201914786       rs201985553       rs202070225       rs202181633       rs267604413       rs367656690       rs367858042       rs367905008       rs368024122       rs368047141       rs368071110       rs368348529       rs368387817       rs369032745       rs369162852       rs369270981       rs369303668       rs369719115       rs369883943       rs370368331       rs370441697       rs370537223       rs370799678       rs370901168       rs372143163       rs372306222       rs372521181       rs372963194       rs373075240       rs373481474       rs373553203       rs373573798       rs373622687       rs373927890       rs374197261       rs374354482       rs374696307       rs374836398       rs375408526       rs375549013       rs376298572       rs376433952       rs376684800       rs376969080       rs377281598       rs377551787       rs377728647       rs527994735       rs529347382       rs529726673       rs529739491       rs529742012       rs530280660       rs530700484       rs530857727       rs531313712       rs532091338       rs532381960       rs533239634       rs534879552       rs535042214       rs535470550       rs535680719       rs536522262       rs537502541       rs537679135       rs537917565       rs538125429       rs538537925       rs538564811       rs539515378       rs539926282       rs540053747       rs540247180       rs540661811       rs541487825       rs541658978       rs542082964       rs542090386       rs542691841       rs543047432       rs543437154       rs543622069       rs544132385       rs545531022       rs545777409       rs546729451       rs546986652       rs547212334       rs547987534       rs548070824       rs548466873       rs548724086       rs548947015       rs549581577       rs549805890       rs549967513       rs550533679       rs550679835       rs551701133       rs552362623       rs552774815       rs553276793       rs553537924       rs553553999       rs553695974       rs554983464       rs555022273       rs555524955       rs557239511       rs557278045       rs558853375       rs558956181       rs560121469       rs560515198       rs560559789       rs560642734       rs561601652       rs562332030       rs562871677       rs563100527       rs563424988       rs564251082       rs564395761       rs564549086       rs565347510       rs565448248       rs565832740       rs565996728       rs566036064       rs566372123       rs566621386       rs567006312       rs567240790       rs567952795       rs568785382       rs568875590       rs569221848       rs569303909       rs569642078       rs569784007       rs570731077       rs570958740       rs571004707       rs571058823       rs571751781       rs572554430       rs572956166       rs573060191       rs574135340       rs574815128       rs574999769       rs575276430       rs575306367       rs577329627       rs577503840       rs745474033       rs745652377       rs745705266       rs745919019       rs745971333       rs746011242       rs746567818       rs746874062       rs746962749       rs747128846       rs747217746       rs747505514       rs747525614       rs747691177       rs747999437       rs748022890       rs748133235       rs748275425       rs748321949       rs748512381       rs748519178       rs748574192       rs748798398       rs748932201       rs749001606       rs749153687       rs749356634       rs749387252       rs749446531       rs749653798       rs749748552       rs749774415       rs750009328       rs750026772       rs750056021       rs750150192       rs750231761       rs750345020       rs750599614       rs750685771       rs751116073       rs751225502       rs751452839       rs751510540       rs751646797       rs751794545       rs751809591       rs751847597       rs751978585       rs752319046       rs752409028       rs752489445       rs752836065       rs752929265       rs753175069       rs753190374       rs753228255       rs753450155       rs753458908       rs753636528       rs753958529       rs754138689       rs754296634       rs754304369       rs754357838       rs754488349       rs754612832       rs754675306       rs754798762       rs755074660       rs755114888       rs755260386       rs755312033       rs755412048       rs755446320       rs755611201       rs755630390       rs755862695       rs755915136       rs755942604       rs756250308       rs756340139       rs756411096       rs756464076       rs756610528       rs756672853       rs756739433       rs756767625       rs757086328       rs757124806       rs757388852       rs757484499       rs757542419       rs757836991       rs757913193       rs757968798       rs758109384       rs758290006       rs759089710       rs759243038       rs759285517       rs759292258       rs759457086       rs759486868       rs759645003       rs759883174       rs759936909       rs760082985       rs760273670       rs760282531       rs760387373       rs760418145       rs760605390       rs760826426       rs760914218       rs760996906       rs761219279       rs761471993       rs761508900       rs761953243       rs761961267       rs762014470       rs762235618       rs762270749       rs762353581       rs762355193       rs762590630       rs762627034       rs762683927       rs762766563       rs763154972       rs763287682       rs763361253       rs763647279       rs763656681       rs763856948       rs763888141       rs764002005       rs764017846       rs764056920       rs764205176       rs764324758       rs764437911       rs764789559       rs764993450       rs765036779       rs765152169       rs765369243       rs765423545       rs765532786       rs765549202       rs765732815       rs765758337       rs765786264       rs766129481       rs766176688       rs766249686       rs766493566       rs766530965       rs766561100       rs766576854       rs766620627       rs766658809       rs766681030       rs766866948       rs766920076       rs766994655       rs767258427       rs767352794       rs767445033       rs767494248       rs767848919       rs767902024       rs768296802       rs768390142       rs768415307       rs768636681       rs769149916       rs769275034       rs769326595       rs769361936       rs769874141       rs769906312       rs769908413       rs770047627       rs770239613       rs770545939       rs770587280       rs770625351       rs770934296       rs770935922       rs771037491       rs771150292       rs771242768       rs771247760       rs771455617       rs771543183       rs771636321       rs771713315       rs771778589       rs772085790       rs772359407       rs772451768       rs772515452       rs772542090       rs772765418       rs772831836       rs772952746       rs772999384       rs773308788       rs773433891       rs773835429       rs774260104       rs774502514       rs774535073       rs774640971       rs774742449       rs774944337       rs774977962       rs775544997       rs775572435       rs775593520       rs775655861       rs775781467       rs775869040       rs775896766       rs776334388       rs776417485       rs776553555       rs776675888       rs776692239       rs776727341       rs776788463       rs776885467       rs777125183       rs777194702       rs777325930       rs777370409       rs777437595       rs777723648       rs778048499       rs778229136       rs778229260       rs778333852       rs778458088       rs778707169       rs778711524       rs778908150       rs778970231       rs779137560       rs779216740       rs779353467       rs779488351       rs779612929       rs779656461       rs779841115       rs779876711       rs780011220       rs780051369       rs780422032       rs780853174       rs781064131       rs781102187       rs781253182       rs781525516       rs781550482      

基因表达

基因表达

TPSD1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
ACAATAATGTGCACCTGCC
58
ATATTCCGCGTTGCAAAGG
59
CATACTGGATGCACTTCTGC
59
ATCCTTGATGTCCGGTTCC
59
TGGACAATAATGTGCACCTG
58
ATATTCCGCGTTGCAAAGG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

TPSD1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

TPSD1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004252
A0A0C4DFZ7(UniProtKB)
IEA
GO:0006508
A0A0C4DFZ7(UniProtKB)
IEA
GO:0004252
Q9BZJ3(UniProtKB)
IEA
GO:0005576
Q9BZJ3(UniProtKB)
IEA
GO:0006508
Q9BZJ3(UniProtKB)
IEA
GO:0008236
Q9BZJ3(UniProtKB)
TAS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控TPSD1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Mastocytosis 0.000814326 3 1 BeFree
Urticaria Pigmentosa 0.000814326 3 1 BeFree
Asthma 0.000271442 1 0 BeFree
Hemangioma 0.000271442 1 0 BeFree
Hyperalgesia 0.000271442 1 0 BeFree
Pulmonary Hypertension 0.000271442 1 0 BeFree
Inflammatory Bowel Diseases 0.000271442 1 0 BeFree
Kidney Diseases 0.000271442 1 0 BeFree
Leukemia, Myelocytic, Acute 0.000271442 1 0 BeFree
Oral Submucous Fibrosis 0.000271442 1 0 BeFree
Aortic Aneurysm, Abdominal 0.000271442 1 0 BeFree
Renal interstitial fibrosis 0.000271442 1 0 BeFree

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