GSTM5(glutathione S-transferase mu 5) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

1p13.3
基因染色体位置图

基因简述

基因简述

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  胞浆和谷胱甘肽S-转移酶的膜结合形式是通过两个不同的表生家族编码。目前，可溶性胞质哺乳动物谷胱甘肽S-转移酶的八个不同类别已经确定：α，KAPPA，亩，欧米茄，PI，西格玛，theta和泽塔。这个基因编码谷胱甘肽S-转移酶属于该亩类。穆类的酶的功能在电子化合物，其中包括致癌物质，治疗药物，环境毒素和氧化应激的产品，通过与谷胱甘肽结合的解毒作用。编码亩类酶的基因在上1p13.3染色体基因簇组织并已知是高度多态性。这些遗传变异可改变个体的易感性致癌物和毒素以及影响某些药物的毒性和疗效。这些基因的多样化已发生区域编码底物结合结构域，以及在组织中的表达模式，以容纳外来化合物的越来越多。 [由RefSeq的，2008年7月提供]

OMIM数据库中对GSTM5基因的介绍     Wikipedia数据库中对GSTM5基因的介绍

基因序列

基因序列

GSTM5基因的碱基序列：[NCBI]

基因突变

基因突变

GSTM5基因的碱基突变：           显示全部snp
rs11807       rs366631       rs414673       rs423875       rs492732       rs493487       rs674761       rs674787       rs886177       rs929166       rs943643       rs1130740       rs1292096       rs1296954       rs1633365       rs1758104       rs1758105       rs1758109       rs1808183       rs2077074       rs2227963       rs2229059       rs2229060       rs2479390       rs3754446       rs3768487       rs3768488       rs3768489       rs3768490       rs3815031       rs3815032       rs3815033       rs4970773       rs7536162       rs7539980       rs11101989       rs11101990      
rs12137743       rs12729068       rs12730212       rs12731384       rs12736389       rs12743015       rs12756544       rs17014553       rs17024661       rs17024723       rs17854972       rs28461755       rs28743105       rs35283204       rs35988844       rs36107407       rs36209416       rs45439194       rs55976052       rs58013442       rs58552265       rs58877308       rs60964769       rs61734547       rs61744262       rs61799818       rs62619926       rs67757008       rs71513971       rs71513972       rs71513973       rs71665048       rs71665049       rs71665050       rs75902385       rs78955679       rs111537945       rs111611566       rs111716188       rs112097400       rs112338301       rs112347797       rs112349671       rs112412754       rs112868171       rs113034727       rs113076642       rs113130058       rs113490310       rs113515562       rs113627447       rs113876350       rs114184542       rs114448003       rs116135843       rs116297791       rs116803889       rs137869431       rs138155304       rs138921077       rs139056212       rs139092225       rs139457478       rs139827543       rs140179217       rs140499099       rs141024360       rs141335395       rs141656810       rs142533115       rs142675425       rs142887282       rs143149060       rs143815763       rs144530836       rs144839885       rs144877199       rs144915668       rs145817177       rs145858840       rs146165082       rs146232109       rs146238475       rs146629350       rs147739570       rs148023691       rs148602914       rs148956224       rs148971515       rs150016475       rs150417585       rs150528860       rs150881777       rs151047871       rs151338560       rs181059134       rs181150599       rs181881751       rs181996027       rs182135541       rs182519427       rs182779137       rs183054770       rs183095440       rs183767310       rs183814729       rs184892393       rs184980302       rs185418615       rs185433327       rs185660366       rs185770769       rs186456905       rs186956316       rs187178229       rs187517145       rs187733347       rs187771098       rs188013476       rs188736734       rs188985869       rs189653312       rs189863370       rs189947119       rs190559770       rs191030500       rs191111715       rs191315651       rs191316763       rs192135306       rs192752839       rs192764865       rs193126784       rs199509387       rs199551890       rs199617959       rs199663929       rs199817098       rs200032114       rs200081331       rs200263181       rs200415768       rs200602485       rs200790981       rs201241248       rs201351635       rs201371910       rs201798232       rs201920628       rs367841609       rs368018483       rs368948360       rs369025115       rs369076757       rs369318855       rs369325436       rs369353755       rs370103381       rs370291520       rs370304540       rs370842568       rs371246652       rs372064554       rs372194104       rs372231434       rs372760694       rs373067309       rs373546102       rs373553495       rs373969317       rs374174216       rs374189642       rs374387077       rs374682957       rs374715062       rs376038941       rs376085310       rs376123412       rs376252099       rs376313197       rs376393852       rs376552617       rs377173992       rs377462045       rs377520590       rs377713984       rs527968330       rs528224941       rs528375852       rs528379720       rs528422296       rs528423457       rs528437100       rs528796565       rs529053897       rs529294292       rs529468548       rs529575067       rs529749102       rs530235020       rs530391455       rs530772271       rs531054724       rs531948239       rs532094249       rs532270704       rs533126651       rs533665979       rs533760695       rs534146423       rs534286575       rs534584730       rs534814809       rs534817535       rs535548828       rs535583591       rs535777678       rs535781897       rs535969102       rs536417953       rs536612833       rs536653827       rs536863936       rs538211705       rs538426705       rs538569476       rs538762886       rs538830143       rs539232064       rs539786494       rs539793651       rs539833976       rs539997602       rs540681323       rs540779576       rs540807268       rs541030643       rs541725758       rs541856200       rs542598739       rs543000174       rs543196772       rs543616079       rs544006329       rs544624373       rs544762165       rs544824725       rs545500286       rs545688203       rs546249249       rs546324417       rs546598252       rs546802431       rs546869525       rs547688810       rs548029377       rs549016006       rs549174154       rs549186896       rs549305896       rs549519836       rs549780138       rs550106553       rs550501798       rs551376441       rs551809457       rs551965589       rs552293247       rs552476166       rs552786778       rs552823870       rs553357181       rs553560026       rs553681063       rs553714154       rs553978862       rs554380038       rs555252847       rs555332062       rs555661185       rs556376020       rs556552715       rs557132008       rs557486754       rs557525364       rs558045349       rs558988233       rs559123118       rs559356142       rs559531415       rs559542759       rs559589774       rs559886740       rs560153966       rs560354194       rs560822723       rs560857893       rs560978021       rs561303087       rs561342151       rs561345548       rs561368875       rs561701428       rs561731673       rs561770299       rs562504127       rs563514083       rs563601501       rs563755627       rs563983345       rs564164666       rs564513149       rs564557059       rs564810916       rs564997006       rs565116209       rs565163311       rs565780563       rs565817602       rs565912665       rs566452271       rs566745986       rs567005929       rs567098777       rs567228082       rs568676762       rs568715964       rs568790780       rs569754560       rs569943724       rs570959466       rs570996709       rs571059945       rs571192674       rs572067199       rs572091294       rs572375341       rs572955480       rs573423097       rs573442917       rs573460852       rs573851033       rs573987296       rs574618414       rs574842564       rs575178382       rs575661552       rs575834684       rs576060700       rs576197050       rs576389382       rs577053457       rs577243521       rs577280952       rs577687708       rs577766307       rs745376046       rs745598595       rs745658624       rs745662372       rs745858669       rs745924825       rs745938007       rs746469769       rs746729123       rs746775469       rs746853877       rs747028227       rs747083013       rs747124202       rs747380458       rs747394710       rs747525031       rs747590299       rs747998265       rs748178780       rs748184410       rs748199010       rs748233611       rs748377378       rs748504900       rs748555644       rs748678179       rs748718540       rs749049379       rs749306864       rs749350566       rs749590345       rs749639725       rs749646059       rs749958044       rs750102221       rs750280586       rs750371938       rs750707456       rs750712026       rs750742789       rs750756073       rs750811084       rs751032335       rs751144481       rs751534779       rs751550204       rs751955105       rs752154779       rs752446386       rs752498575       rs752673294       rs753093870       rs753187583       rs753244635       rs753414142       rs753528006       rs753583607       rs753612715       rs753614655       rs753798822       rs754131086       rs754218643       rs754218698       rs754410625       rs754612756       rs754726820       rs754852155       rs754907592       rs755094822       rs755411906       rs755633122       rs755755142       rs755788970       rs755847977       rs756202067       rs756227186       rs756449097       rs756500064       rs756521706       rs756805561       rs756991544       rs757100365       rs757486209       rs757611496       rs757632728       rs757793938       rs758211610       rs758262942       rs758458400       rs758551186       rs758824699       rs758876135       rs759041825       rs759081574       rs759085563       rs759107188       rs759300282       rs759603785       rs759864751       rs759918069       rs760275886       rs760473260       rs760473991       rs760494900       rs760695304       rs760807836       rs760863335       rs761380041       rs761401295       rs761418660       rs761590881       rs761745813       rs761764699       rs761981861       rs762006092       rs762227004       rs762327495       rs762554408       rs762580376       rs762701449       rs762758508       rs762807389       rs762933821       rs763216336       rs763310912       rs763455515       rs763581563       rs763750062       rs763940489       rs764048930       rs764069830       rs764512897       rs764902310       rs764970372       rs765072284       rs765138941       rs765276114       rs765381351       rs765636678       rs765717449       rs766046580       rs766103770       rs766139866       rs766544714       rs766716146       rs766787362       rs766842191       rs766880895       rs767207301       rs767389687       rs767522090       rs767764856       rs767818131       rs767826963       rs767881763       rs768145455       rs768173148       rs768400184       rs768442636       rs768656814       rs768810313       rs768877281       rs769236234       rs769575947       rs769757259       rs769810313       rs769866395       rs769954259       rs770003591       rs770258231       rs770490142       rs770499091       rs770531083       rs770670957       rs770746740       rs770886469       rs770941422       rs770985736       rs771357549       rs771667623       rs771720862       rs772244239       rs772605835       rs772663007       rs772712177       rs772800308       rs772817910       rs773188187       rs773305763       rs773329136       rs773389975       rs773440782       rs773672352       rs773862477       rs774041936       rs774082011       rs774094840       rs774193643       rs774211332       rs774532348       rs774608604       rs774713773       rs774795395       rs775069987       rs775193894       rs775221811       rs775587853       rs775737513       rs775764050       rs775844554       rs775856594       rs776229738       rs776291300       rs776705081       rs776706310       rs776755683       rs776895830       rs776943471       rs777202913       rs777293297       rs777719481       rs777824250       rs778023983       rs778197170       rs778331898       rs778342762       rs778686057       rs778737926       rs778846904       rs779108208       rs779427479       rs779480058       rs779598590       rs779725469       rs779939400       rs780049012       rs780090239       rs780370005       rs780458889       rs780564561       rs780582876       rs780729534       rs780809666       rs780864930       rs781540318       rs781591595       rs781701486       rs781717042       rs781731912       rs781745795      

基因表达

基因表达

GSTM5基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GACTTTCCCAATCTGCCCT
60
AATCTTCTCCTCTTCTGTCTCC
59
TACTTGGAGGAACTCCCTG
58
AAAGGTGATCTTGTCTCCTG
57
TACTTGGAGGAACTCCCTG
58
AAAGGTGATCTTGTCTCCTG
57
GTTTGCAGGAGACAAGATCAC
59
GCACTTGGGCTCAAATATACG
59
GTTTGCAGGAGACAAGATCAC
60
CACTTGGGCTCAAATATACGC
60
ACATCCGTGGGTGAATAGC
60
ACTGTAGCTGAAGCACTCG
60
GCGTATATTTGAGCCCAAGTG
60
ATCTTCTTCAAACCCTCAAAGC
59
TACTTGGAGGAACTCCCTG
58
AAAGGTGATCTTGTCTCCTG
57
ACATCCGTGGGTGAATAGC
60
CCAGACTGTAGCTGAAGCA
59
AGGAGAAGATTCGTGTGGAC
60
CAGTTTCTCAAACTCTGGGTG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

GSTM5基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

GSTM5基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004364
P46439(UniProtKB)
IDA
GO:0004364
P46439(UniProtKB)
TAS
GO:0005515
P46439(UniProtKB)
IPI
GO:0005515
P46439(UniProtKB)
IPI
GO:0005829
P46439(UniProtKB)
TAS
GO:0006749
P46439(UniProtKB)
IDA
GO:1901687
P46439(UniProtKB)
TAS
GO:0004364
Q5T8Q9(UniProtKB)
IEA
GO:0008152
Q5T8Q9(UniProtKB)
IEA
GO:0004364
Q5T8R1(UniProtKB)
IEA
GO:0008152
Q5T8R1(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控GSTM5基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Colonic Neoplasms 0.12 1 0 CTD_human
Neurodegenerative Disorders 0.12 1 0 CTD_human
Autistic Disorder 0.08 0 0 MGD
Hypertensive disease 0.002638474 1 1 BeFree_GAD
Atherosclerosis 0.002367032 1 0 GAD
Malignant neoplasm of breast 0.002367032 1 0 GAD
Coronary heart disease 0.002367032 1 0 GAD
Head and Neck Neoplasms 0.002367032 1 0 GAD
Neoplasm Recurrence, Local 0.002367032 1 0 GAD
Prenatal Exposure Delayed Effects 0.002367032 1 0 GAD
Neoplasms, Second Primary 0.002367032 1 0 GAD
Malignant neoplasm of lung 0.002367032 1 0 GAD
Adenocarcinoma 0.000271442 1 0 BeFree
Ischemia 0.000271442 1 0 BeFree
Age related macular degeneration 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因评论

基因评论

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