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This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
[中文简述(自动翻译):]  此基因是异戊烯转移家族的成员,并编码具有香叶基香叶基二磷酸(GGPP)合酶活性的蛋白质。酶催化GGPP的从法尼基二磷酸和异戊烯二磷酸的合成。 GGPP负责蛋白质的C20-异戊二烯化和核激素受体的调节的重要分子。备用转录剪接变体,既蛋白编码和非蛋白编码,已发现这种基因。 [由RefSeq的,2010年9月提供]
GGPS1基因(以及对应的蛋白质)的细胞分布位置:
GGPS1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Hyperinsulinism | 0.000271442 | 1 | 0 | BeFree |
| Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Osteoporosis | 0.000271442 | 1 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
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