FZD4(frizzled class receptor 4) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

11q14-q21
基因染色体位置图

基因简述

基因简述

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  此基因是卷曲基因家族的一个成员。是受体无翅型MMTV整合位点家族信号蛋白的这个家族编码七跨膜结构域蛋白的成员。最卷曲受体耦合到β-连环蛋白典型信号通路。这种蛋白可以发挥作用的无翅型MMTV整合位点信号传导途径的正调节。一个转录变体保留内含子序列和编码一种短的同种型进行了说明，但是，其表达不能被其他的实验证据的支持。 [由RefSeq的，2008年7月提供]

OMIM数据库中对FZD4基因的介绍     Wikipedia数据库中对FZD4基因的介绍

基因序列

基因序列

FZD4基因的碱基序列：[NCBI]

基因突变

基因突变

FZD4基因的碱基突变：           显示全部snp
rs15135       rs713065       rs1045393       rs3740661       rs3740662       rs3758658       rs3802892       rs4944641       rs4944642       rs7940477       rs10898563       rs11234890       rs34325935       rs34783237       rs56126837       rs56319409       rs56400333       rs57074558       rs58204343       rs58446382       rs58750277       rs59987244       rs60226660       rs60283648       rs61088092       rs61735303       rs61735304       rs61749246       rs61903831       rs71470714       rs72963441       rs72963450       rs73531344       rs74513685       rs74881730       rs75557858       rs76095431      
rs76207750       rs76210279       rs76524171       rs77034986       rs77135432       rs77424184       rs77464913       rs77503270       rs77957825       rs78804007       rs78806773       rs79135599       rs79166334       rs79579807       rs79807722       rs80075834       rs80174943       rs80358282       rs80358284       rs80358293       rs80358295       rs80358300       rs104894223       rs112177728       rs113117399       rs113527642       rs113832498       rs113917021       rs114459852       rs115341334       rs115557428       rs117822848       rs117941971       rs118039628       rs138038210       rs138561450       rs138794842       rs139401671       rs139460265       rs139511834       rs139871961       rs140295117       rs140601725       rs140932320       rs141047241       rs141140009       rs141874425       rs141895567       rs141978964       rs142087983       rs142618839       rs142635340       rs142835722       rs143269985       rs143372848       rs143757970       rs144036448       rs144293521       rs144358659       rs144807523       rs145072875       rs145315744       rs145488673       rs145679440       rs145866677       rs145929150       rs146277634       rs146895719       rs147043943       rs147500733       rs147660178       rs147766472       rs147967476       rs148336100       rs148448468       rs148616777       rs148672481       rs148843702       rs148970041       rs149140011       rs149300801       rs149547681       rs149696251       rs149837228       rs150941414       rs150947482       rs151171808       rs180680385       rs181367055       rs181808329       rs182049165       rs182087640       rs182891556       rs182907379       rs183437737       rs183451293       rs183805331       rs184657785       rs184709254       rs184796229       rs185157734       rs186195944       rs186342366       rs187088461       rs187559867       rs188015808       rs188043127       rs188461616       rs188819303       rs189105376       rs189335053       rs189700059       rs191251578       rs191314012       rs191526999       rs192151920       rs192608327       rs192893764       rs199577384       rs199837706       rs200014931       rs200109854       rs200205053       rs201077120       rs201168680       rs201256460       rs201457319       rs201907845       rs201914515       rs202091546       rs368313134       rs368527723       rs368580363       rs368854863       rs368906165       rs369255094       rs369356024       rs369596520       rs369763103       rs369854962       rs370046062       rs370591370       rs370690635       rs370738860       rs370811133       rs371128840       rs371290679       rs371672722       rs371704478       rs371800907       rs371867662       rs372319612       rs372852310       rs373565387       rs373872905       rs374428856       rs374499509       rs375123597       rs375213001       rs375581888       rs375818153       rs376559208       rs376854255       rs377443153       rs377527854       rs377696818       rs527273179       rs527339048       rs527399393       rs527675809       rs527684830       rs527788508       rs527939713       rs527950222       rs528005719       rs528348145       rs528411909       rs529231737       rs529652287       rs530309354       rs530372622       rs530613772       rs530658595       rs530670766       rs530994733       rs531265833       rs531328250       rs531860991       rs531871098       rs532010386       rs532321640       rs532417375       rs532738457       rs533389592       rs533528848       rs533584251       rs533839311       rs534368562       rs534530796       rs534813313       rs535089281       rs535497508       rs535500224       rs536162640       rs536429568       rs536833449       rs537418626       rs537438989       rs538483998       rs538569108       rs538873983       rs539135721       rs539487296       rs540006785       rs540068530       rs540191802       rs540778388       rs541479825       rs541481816       rs541754009       rs542000526       rs542033644       rs542063724       rs542391665       rs543771832       rs544106319       rs544218300       rs544245041       rs544568108       rs545446073       rs545953154       rs546016745       rs546558127       rs547098195       rs547110801       rs547341323       rs547668271       rs547979627       rs548042559       rs548377194       rs548440337       rs548787364       rs549067034       rs549713666       rs549795130       rs550144999       rs550434409       rs550778413       rs550787317       rs550918541       rs551452127       rs551459676       rs551786923       rs551949785       rs552042871       rs552492300       rs552525438       rs552848068       rs553247658       rs553511620       rs553574945       rs553640727       rs554436282       rs554735120       rs554911760       rs554965186       rs555099677       rs555354966       rs555500541       rs555553679       rs556037440       rs556412849       rs557211611       rs557348728       rs557425553       rs558163435       rs558502224       rs558948292       rs559089109       rs559543312       rs560199239       rs560649393       rs561552180       rs561613009       rs562042557       rs562056288       rs562688071       rs562725038       rs562826356       rs562881517       rs563155866       rs563169065       rs563441127       rs563737017       rs563869036       rs563895233       rs563987584       rs564051011       rs564218136       rs564686629       rs564834060       rs565087768       rs565560646       rs565772237       rs565894145       rs566027985       rs566152666       rs566529091       rs566538340       rs566786953       rs567477010       rs567848877       rs568008260       rs568354656       rs568828752       rs568903306       rs569564089       rs569872828       rs570238214       rs570563555       rs570839659       rs570920994       rs571049940       rs571948106       rs572009315       rs572460069       rs572535087       rs572598819       rs573000813       rs573013571       rs573091130       rs573227026       rs573632173       rs573770292       rs574064098       rs574442380       rs575033289       rs575049115       rs575136299       rs575419546       rs576454253       rs577019309       rs577048598       rs577153136       rs577177813       rs577552759       rs577823166       rs745360980       rs745451086       rs745745495       rs745770534       rs745965975       rs746470330       rs746490303       rs746558042       rs746622437       rs747068280       rs747156359       rs747158245       rs747424675       rs747774998       rs747925802       rs747931382       rs748018430       rs748190939       rs748642261       rs748812870       rs748893139       rs749017436       rs749072941       rs749165815       rs749358883       rs749738642       rs749864267       rs749958709       rs750040956       rs750235587       rs750457541       rs750475586       rs750507065       rs750701201       rs750922592       rs751317286       rs751357773       rs751569430       rs751738021       rs752241404       rs752499453       rs752642111       rs752809376       rs752836331       rs752864698       rs752990226       rs753062807       rs753388992       rs753775277       rs753949923       rs753968356       rs754483582       rs754959108       rs754975604       rs754977266       rs755154938       rs755528979       rs755666283       rs755789676       rs756119359       rs756589557       rs756626640       rs756712342       rs756889974       rs756932392       rs757051636       rs757399065       rs757405807       rs757443663       rs757834087       rs757850482       rs758053714       rs758252104       rs758288341       rs758540332       rs758630124       rs758979364       rs759432455       rs759772249       rs759867904       rs759890542       rs759980701       rs760018638       rs760286409       rs760508472       rs760635095       rs760889970       rs761000333       rs761378697       rs761495510       rs761683698       rs761845677       rs762138071       rs762249754       rs762602463       rs762727431       rs762880247       rs763356711       rs763395503       rs763480908       rs763482999       rs763843440       rs764357846       rs764392486       rs764395748       rs764591103       rs764592458       rs764654861       rs764902681       rs765006104       rs765359794       rs765524602       rs765757872       rs765834466       rs766074842       rs766393047       rs766436611       rs766574964       rs766777602       rs766880986       rs766980472       rs767255289       rs767451434       rs767577234       rs767702233       rs767886264       rs768216168       rs768413379       rs768431477       rs768615123       rs768939073       rs769157239       rs769786110       rs770144336       rs770263423       rs770432329       rs770501338       rs770760702       rs770841790       rs771038159       rs771158006       rs771381203       rs771625436       rs771911050       rs772097050       rs772131787       rs772349259       rs772616674       rs772965455       rs772974099       rs773169981       rs773474310       rs773996425       rs774200714       rs774232650       rs774694389       rs774774917       rs774854581       rs774888661       rs775081751       rs775174655       rs775450620       rs775641791       rs775708398       rs775817244       rs776017294       rs776026462       rs776497653       rs776761519       rs777030284       rs777153219       rs777338316       rs777565148       rs777762460       rs777938879       rs778027186       rs778512862       rs778700523       rs778781079       rs778868934       rs779086471       rs779172777       rs779257431       rs779471979       rs779827851       rs779931194       rs780102146       rs780500837       rs780703563       rs780777696       rs780793516       rs781161667       rs781192701       rs781239165       rs781634932       rs547110801      

基因表达

基因表达

FZD4基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TACAACGTGACCAAGATGC
58
AAAGGAAGAACTGCAGCTG
58
TACAACGTGACCAAGATGC
58
CAAAGGAAGAACTGCAGCT
58
CTACAACGTGACCAAGATGC
59
AAAGGAAGAACTGCAGCTG
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

FZD4基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

FZD4基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001570
Q9ULV1(UniProtKB)
IEA
GO:0004930
Q9ULV1(UniProtKB)
IBA
GO:0005515
Q9ULV1(UniProtKB)
IPI
GO:0005515
Q9ULV1(UniProtKB)
IPI
GO:0005515
Q9ULV1(UniProtKB)
IPI
GO:0005515
Q9ULV1(UniProtKB)
IPI
GO:0005515
Q9ULV1(UniProtKB)
IPI
GO:0005886
Q9ULV1(UniProtKB)
IDA
GO:0005886
Q9ULV1(UniProtKB)
IDA
GO:0005886
Q9ULV1(UniProtKB)
IDA
GO:0005886
Q9ULV1(UniProtKB)
TAS
GO:0005886
Q9ULV1(UniProtKB)
TAS
GO:0005886
Q9ULV1(UniProtKB)
TAS
GO:0005886
Q9ULV1(UniProtKB)
TAS
GO:0005886
Q9ULV1(UniProtKB)
TAS
GO:0005886
Q9ULV1(UniProtKB)
TAS
GO:0005886
Q9ULV1(UniProtKB)
TAS
GO:0005886
Q9ULV1(UniProtKB)
TAS
GO:0005886
Q9ULV1(UniProtKB)
TAS
GO:0005886
Q9ULV1(UniProtKB)
TAS
GO:0005886
Q9ULV1(UniProtKB)
TAS
GO:0005887
Q9ULV1(UniProtKB)
IC
GO:0005911
Q9ULV1(UniProtKB)
IEA
GO:0007186
Q9ULV1(UniProtKB)
IEA
GO:0007223
Q9ULV1(UniProtKB)
IDA
GO:0007223
Q9ULV1(UniProtKB)
TAS
GO:0007605
Q9ULV1(UniProtKB)
IEA
GO:0009986
Q9ULV1(UniProtKB)
IDA
GO:0010812
Q9ULV1(UniProtKB)
IMP
GO:0016021
Q9ULV1(UniProtKB)
IBA
GO:0016055
Q9ULV1(UniProtKB)
IDA
GO:0016055
Q9ULV1(UniProtKB)
IDA
GO:0017147
Q9ULV1(UniProtKB)
IBA
GO:0019955
Q9ULV1(UniProtKB)
IPI
GO:0030165
Q9ULV1(UniProtKB)
IPI
GO:0030165
Q9ULV1(UniProtKB)
IPI
GO:0030165
Q9ULV1(UniProtKB)
IPI
GO:0030165
Q9ULV1(UniProtKB)
IDA
GO:0030182
Q9ULV1(UniProtKB)
ISS
GO:0030669
Q9ULV1(UniProtKB)
TAS
GO:0030947
Q9ULV1(UniProtKB)
IEA
GO:0031625
Q9ULV1(UniProtKB)
IPI
GO:0031987
Q9ULV1(UniProtKB)
IEA
GO:0034446
Q9ULV1(UniProtKB)
IEA
GO:0035426
Q9ULV1(UniProtKB)
IEA
GO:0042701
Q9ULV1(UniProtKB)
IEA
GO:0042803
Q9ULV1(UniProtKB)
IPI
GO:0042813
Q9ULV1(UniProtKB)
IDA
GO:0043507
Q9ULV1(UniProtKB)
IEA
GO:0045893
Q9ULV1(UniProtKB)
IDA
GO:0045893
Q9ULV1(UniProtKB)
IDA
GO:0046982
Q9ULV1(UniProtKB)
IPI
GO:0051091
Q9ULV1(UniProtKB)
IDA
GO:0060070
Q9ULV1(UniProtKB)
IDA
GO:0060070
Q9ULV1(UniProtKB)
IDA
GO:0060071
Q9ULV1(UniProtKB)
TAS
GO:0061299
Q9ULV1(UniProtKB)
IMP
GO:0061299
Q9ULV1(UniProtKB)
IMP
GO:0061301
Q9ULV1(UniProtKB)
IEA
GO:0061304
Q9ULV1(UniProtKB)
IEA
GO:0070062
Q9ULV1(UniProtKB)
IDA
GO:0071300
Q9ULV1(UniProtKB)
ISS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控FZD4基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Exudative vitreoretinopathy 1 0.440814326 11 4 BeFree_CTD_human_MGD_ORPHANET_UNIPROT
Familial Exudative Vitreoretinopathy 0.131053172 32 3 BeFree_GAD_ORPHANET
Retinopathy of Prematurity 0.128186863 5 0 BeFree_GAD_ORPHANET
Retinal Diseases 0.125276948 5 0 BeFree_CTD_human_GAD
Arachnodactyly 0.12 1 0 CTD_human
Cleft Palate 0.12 1 0 CTD_human
Syndactyly 0.12 1 0 CTD_human
Persistent Hyperplastic Primary Vitreous 0.12 0 0 ORPHANET
Craniofacial Abnormalities 0.12 1 0 CTD_human
Norrie disease 0.081085767 4 0 BeFree_MGD
Leukemia, Myelocytic, Acute 0.00272435 1 0 LHGDN
Disorder of eye 0.002367032 1 0 GAD
Head and Neck Neoplasms 0.002367032 1 0 GAD
Neoplasm Recurrence, Local 0.002367032 1 0 GAD
Neoplasms, Second Primary 0.002367032 1 0 GAD
Proliferative vitreoretinopathy 0.002367032 1 0 GAD
Malignant neoplasm of prostate 0.001628651 6 0 BeFree
Prostate carcinoma 0.001628651 6 0 BeFree
HIV Infections 0.001085767 4 0 BeFree
Tumor Progression 0.001085767 4 0 BeFree
Asthma 0.000814326 3 0 BeFree
Glioma 0.000814326 3 0 BeFree
Heart failure 0.000814326 3 0 BeFree
Congestive heart failure 0.000814326 3 0 BeFree
Retinal Detachment 0.000814326 3 0 BeFree
Tumor Angiogenesis 0.000814326 3 0 BeFree
Squamous cell carcinoma 0.000542884 2 0 BeFree
melanoma 0.000542884 2 0 BeFree
Obesity 0.000542884 2 0 BeFree
Taste bitter 0.000542884 2 0 BeFree
Neurodegenerative Disorders 0.000542884 2 0 BeFree
Carcinogenesis 0.000542884 2 0 BeFree
Conn Syndrome 0.000542884 2 0 BeFree
Albinism 0.000271442 1 0 BeFree
Mental disorders 0.000271442 1 0 BeFree
Malignant neoplasm of urinary bladder 0.000271442 1 0 BeFree
Blood Coagulation Disorders 0.000271442 1 0 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.000271442 1 0 BeFree
Gastroesophageal reflux disease 0.000271442 1 0 BeFree
Glioblastoma 0.000271442 1 0 BeFree
granulosa cell tumor 0.000271442 1 0 BeFree
Huntington Disease 0.000271442 1 0 BeFree
Ischemia 0.000271442 1 0 BeFree
Macular degeneration 0.000271442 1 0 BeFree
Microcephaly 0.000271442 1 0 BeFree
Degenerative polyarthritis 0.000271442 1 0 BeFree
Exudative retinopathy 0.000271442 1 0 BeFree
Neuroendocrine Tumors 0.000271442 1 0 BeFree
Pancreatic carcinoma 0.000271442 1 0 BeFree
Age related macular degeneration 0.000271442 1 0 BeFree
Rhegmatogenous retinal detachment 0.000271442 1 0 BeFree
Choroidal and/or chorioretinal disorder 0.000271442 1 0 BeFree
Carcinoma of bladder 0.000271442 1 0 BeFree
Malignant Pleural Mesothelioma 0.000271442 1 0 BeFree
Cancer Cell Growth 0.000271442 1 0 BeFree
Acth-Independent Macronodular Adrenal Hyperplasia 0.000271442 1 0 BeFree

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