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This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因产物被认为是参与加工preribosomal RNA中的第一工序的核仁小核糖核蛋白(核蛋白)粒子的组分。它与U3,U8和U13小核RNA的相关联,并且位于细胞核的致密纤维成分(DFC)。所编码的蛋白质含有N-末端重复区是富含甘氨酸和精氨酸残基,如在其他物种fibrillarins。其中心区域就像一个RNA结合结构域,并包含一个RNP共有序列。从与自身免疫性疾病硬皮病人类约8%的抗血清识别fibrillarin。 [由RefSeq的,2008年7月提供]
FBL基因(以及对应的蛋白质)的细胞分布位置:
FBL基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Autoimmune Diseases | 0.120271442 | 4 | 0 | BeFree_CTD_human |
| Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Fibrosis, Liver | 0.001900093 | 7 | 1 | BeFree |
| Systemic Scleroderma | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
| Scleroderma | 0.000542884 | 2 | 0 | BeFree |
| HIV Infections | 0.000542884 | 2 | 1 | BeFree |
| Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
| Non-alcoholic Fatty Liver Disease | 0.000542884 | 2 | 0 | BeFree |
| Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Liver diseases | 0.000271442 | 1 | 0 | BeFree |
| Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Fibroadenoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Invasive Ductal Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
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