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This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
[中文简述(自动翻译):]  该基??因编码的多梳组(PCG)家族中的一员。 PCG家族成员形成多聚体蛋白质复合物,这是参与维持基因的转录抑制状态在连续细胞世代。这种蛋白质同伙与胚胎外胚层发育蛋白质,所述VAV1癌蛋白,和X-连锁的核蛋白质。这种蛋白可能在造血和中枢神经系统的作用。多或者splcied转录变异体的编码不同的亚型已经确定了这个基因。 [由RefSeq的,2011年2月提供]
EZH2基因(以及对应的蛋白质)的细胞分布位置:
EZH2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Weaver syndrome | 0.361085767 | 4 | 9 | BeFree_CLINVAR_ORPHANET_UNIPROT |
| Prostatic Neoplasms | 0.14560492 | 16 | 0 | BeFree_CTD_human_LHGDN |
| Mammary Neoplasms | 0.136607612 | 17 | 0 | BeFree_CTD_human_LHGDN |
| Lymphoma, Follicular | 0.122714419 | 11 | 0 | BeFree_CTD_human |
| Diffuse Large B-Cell Lymphoma | 0.122714419 | 11 | 0 | BeFree_CTD_human |
| Osteosarcoma | 0.120542884 | 3 | 0 | BeFree_CTD_human |
| MYELODYSPLASTIC SYNDROME | 0.120542884 | 3 | 0 | BeFree_CTD_human |
| Primary Myelofibrosis | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Craniosynostosis | 0.12 | 1 | 0 | CTD_human |
| Endometrial Neoplasms | 0.12 | 1 | 0 | CTD_human |
| IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
| Juvenile Myelomonocytic Leukemia | 0.12 | 1 | 0 | CTD_human |
| Upper Extremity Deformities, Congenital | 0.12 | 1 | 0 | CTD_human |
| Myelodysplastic-Myeloproliferative Diseases | 0.12 | 1 | 0 | CTD_human |
| Leukemia, Megakaryoblastic, of Down Syndrome | 0.12 | 1 | 0 | CTD_human |
| Pancreatic Neoplasm | 0.082995792 | 3 | 0 | BeFree_LHGDN_RGD |
| Non-alcoholic Fatty Liver Disease | 0.080271442 | 1 | 0 | BeFree_RGD |
| Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
| Fibroid Tumor | 0.08 | 1 | 0 | RGD |
| Left Ventricular Hypertrophy | 0.08 | 1 | 0 | RGD |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.08 | 0 | 0 | MGD |
| Malignant neoplasm of prostate | 0.019663367 | 56 | 0 | BeFree_GAD |
| Carcinogenesis | 0.018458047 | 68 | 1 | BeFree |
| Neoplasm Metastasis | 0.015482118 | 47 | 0 | BeFree_LHGDN |
| Prostate carcinoma | 0.015200745 | 56 | 0 | BeFree |
| Malignant neoplasm of breast | 0.012214884 | 45 | 0 | BeFree |
| Breast Carcinoma | 0.011943442 | 44 | 0 | BeFree |
| Liver carcinoma | 0.010606096 | 19 | 0 | BeFree_LHGDN |
| Lymphoma | 0.008414698 | 31 | 1 | BeFree |
| Tumor Progression | 0.007871814 | 29 | 0 | BeFree |
| melanoma | 0.007077352 | 8 | 0 | BeFree_LHGDN |
| Malignant neoplasm of lung | 0.005624334 | 12 | 0 | BeFree_GAD |
| Stomach Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
| leukemia | 0.005352893 | 12 | 0 | BeFree_GAD |
| Non-Small Cell Lung Carcinoma | 0.00434307 | 16 | 0 | BeFree |
| Renal Cell Carcinoma | 0.00408156 | 5 | 0 | BeFree_LHGDN |
| Ovarian Carcinoma | 0.004071628 | 15 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.003800186 | 14 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.003528744 | 13 | 0 | BeFree |
| Stomach Carcinoma | 0.003528744 | 13 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.003528744 | 13 | 0 | BeFree |
| Lymphoma, Non-Hodgkin | 0.003452799 | 5 | 0 | BeFree_GAD |
| Noninfiltrating Intraductal Carcinoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Colorectal Carcinoma | 0.003257302 | 12 | 0 | BeFree |
| Glioblastoma | 0.003257302 | 12 | 0 | BeFree |
| Pancreatic carcinoma | 0.003257302 | 12 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.003257302 | 12 | 0 | BeFree |
| Carcinoma of lung | 0.003257302 | 12 | 0 | BeFree |
| B-Cell Lymphomas | 0.002985861 | 11 | 0 | BeFree |
| Epithelial ovarian cancer | 0.002985861 | 11 | 0 | BeFree |
| Colorectal Cancer | 0.002985861 | 11 | 0 | BeFree |
| Hyperplasia | 0.00272435 | 1 | 0 | LHGDN |
| Nevus | 0.00272435 | 1 | 0 | LHGDN |
| Squamous cell carcinoma | 0.002714419 | 10 | 0 | BeFree |
| Glioma | 0.002714419 | 10 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.002714419 | 10 | 0 | BeFree |
| Carcinoma of bladder | 0.002714419 | 10 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.002714419 | 10 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.002442977 | 9 | 0 | BeFree |
| Metastatic Prostate Carcinoma | 0.002442977 | 9 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Solid tumour | 0.001628651 | 6 | 0 | BeFree |
| Leukemogenesis | 0.001628651 | 6 | 0 | BeFree |
| Malignant tumor of cervix | 0.001357209 | 5 | 0 | BeFree |
| Small cell carcinoma of lung | 0.001357209 | 5 | 0 | BeFree |
| Squamous cell carcinoma of esophagus | 0.001357209 | 5 | 0 | BeFree |
| Cervix carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of liver | 0.001357209 | 5 | 0 | BeFree |
| Invasive breast carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Pancreatic Ductal Adenocarcinoma | 0.001357209 | 5 | 0 | BeFree |
| Xenograft Model | 0.001357209 | 5 | 0 | BeFree |
| Malignant tumor of colon | 0.001085767 | 4 | 0 | BeFree |
| Multiple Myeloma | 0.001085767 | 4 | 0 | BeFree |
| Retinoblastoma | 0.001085767 | 4 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Transitional cell carcinoma of bladder | 0.001085767 | 4 | 0 | BeFree |
| Colon Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.001085767 | 4 | 0 | BeFree |
| Sarcoma | 0.001085767 | 4 | 0 | BeFree |
| Glioblastoma Multiforme | 0.001085767 | 4 | 0 | BeFree |
| Astrocytoma | 0.000814326 | 3 | 0 | BeFree |
| Bladder Neoplasm | 0.000814326 | 3 | 0 | BeFree |
| Medulloblastoma | 0.000814326 | 3 | 0 | BeFree |
| Neuroblastoma | 0.000814326 | 3 | 0 | BeFree |
| Preleukemia | 0.000814326 | 3 | 0 | BeFree |
| Acute leukemia | 0.000814326 | 3 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000814326 | 3 | 0 | BeFree |
| Rhabdoid Tumor | 0.000814326 | 3 | 0 | BeFree |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000814326 | 3 | 0 | BeFree |
| Recurrent tumor | 0.000814326 | 3 | 0 | BeFree |
| Thyroid carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Ewings sarcoma | 0.000814326 | 3 | 0 | BeFree |
| Central neuroblastoma | 0.000814326 | 3 | 0 | BeFree |
| ovarian neoplasm | 0.000814326 | 3 | 0 | BeFree |
| Hepatocarcinogenesis | 0.000814326 | 3 | 0 | BeFree |
| Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
| Brain Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Burkitt Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of endometrium | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of thyroid | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma, Transitional Cell | 0.000542884 | 2 | 0 | BeFree |
| Esophageal Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| HIV Infections | 0.000542884 | 2 | 0 | BeFree |
| Myeloid Leukemia, Chronic | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, Myelomonocytic, Chronic | 0.000542884 | 2 | 0 | BeFree |
| Adult T-Cell Lymphoma/Leukemia | 0.000542884 | 2 | 0 | BeFree |
| Lung Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Lupus Erythematosus, Systemic | 0.000542884 | 2 | 0 | BeFree |
| Precancerous Conditions | 0.000542884 | 2 | 0 | BeFree |
| Rhabdomyosarcoma | 0.000542884 | 2 | 0 | BeFree |
| T-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000542884 | 2 | 0 | BeFree |
| Cutaneous Melanoma | 0.000542884 | 2 | 0 | BeFree |
| Esophageal carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of mouth | 0.000542884 | 2 | 0 | BeFree |
| Cholangiocarcinoma | 0.000542884 | 2 | 0 | BeFree |
| Uveal melanoma | 0.000542884 | 2 | 0 | BeFree |
| Lip and Oral Cavity Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Anaplastic thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Parathyroid Adenoma | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000542884 | 2 | 0 | BeFree |
| Non-small cell lung cancer stage I | 0.000542884 | 2 | 0 | BeFree |
| Inflammatory Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Conventional (Clear Cell) Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Multiple malignancy | 0.000542884 | 2 | 0 | BeFree |
| Hematologic Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Endometrial Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Secondary malignant neoplasm of liver | 0.000542884 | 2 | 0 | BeFree |
| Malignant Glioma | 0.000542884 | 2 | 0 | BeFree |
| Osteosarcoma of bone | 0.000542884 | 2 | 0 | BeFree |
| Malignant Peripheral Nerve Sheath Tumor | 0.000542884 | 2 | 0 | BeFree |
| Intraepithelial Neoplasia | 0.000542884 | 2 | 0 | BeFree |
| Invasive Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Renal carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Benign Prostatic Hyperplasia | 0.000542884 | 2 | 0 | BeFree |
| Non-Neoplastic Disorder | 0.000542884 | 2 | 0 | BeFree |
| Uterine Corpus Cancer | 0.000542884 | 2 | 0 | BeFree |
| Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
| Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
| Anaplasia | 0.000271442 | 1 | 0 | BeFree |
| Aplastic Anemia | 0.000271442 | 1 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Ataxia Telangiectasia | 0.000271442 | 1 | 0 | BeFree |
| Tooth Attrition | 0.000271442 | 1 | 0 | BeFree |
| Autoimmune Diseases | 0.000271442 | 1 | 0 | BeFree |
| Bacterial Infections | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
| Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
| Cystadenoma | 0.000271442 | 1 | 0 | BeFree |
| Diabetes | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
| Down Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Muscular Dystrophy, Duchenne | 0.000271442 | 1 | 0 | BeFree |
| Epithelial hyperplasia | 0.000271442 | 1 | 0 | BeFree |
| Hyperparathyroidism | 0.000271442 | 1 | 0 | BeFree |
| Hyperparathyroidism, Secondary | 0.000271442 | 1 | 0 | BeFree |
| Ischemia | 0.000271442 | 1 | 0 | BeFree |
| Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, T-Cell | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, T-Cell, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Leukoplakia, Oral | 0.000271442 | 1 | 0 | BeFree |
| Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Lupus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
| Lupus Erythematosus, Discoid | 0.000271442 | 1 | 0 | BeFree |
| Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
| Myelofibrosis | 0.000271442 | 1 | 0 | BeFree |
| Embryonal Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
| oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
| Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
| Parathyroid Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Pemphigus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
| polyps | 0.000271442 | 1 | 0 | BeFree |
| Kaposi Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
| synovial sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Teratoma | 0.000271442 | 1 | 0 | BeFree |
| Lentivirus Infections | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma, Large-Cell, Follicular | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic pulmonary hypertension | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of tongue | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of brain | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of bone | 0.000271442 | 1 | 0 | BeFree |
| Right Ventricular Hypertrophy | 0.000271442 | 1 | 0 | BeFree |
| Sarcoma, Epithelioid | 0.000271442 | 1 | 0 | BeFree |
| Cervical Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
| Metastatic malignant neoplasm to brain | 0.000271442 | 1 | 0 | BeFree |
| Mastocytosis, Systemic | 0.000271442 | 1 | 0 | BeFree |
| Gallbladder Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Hereditary pancreatitis | 0.000271442 | 1 | 0 | BeFree |
| Medullary carcinoma of thyroid | 0.000271442 | 1 | 0 | BeFree |
| Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Fibrosis, Liver | 0.000271442 | 1 | 0 | BeFree |
| Multiple tumors | 0.000271442 | 1 | 0 | BeFree |
| Acquired aplastic anemia | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of colon stage IV | 0.000271442 | 1 | 0 | BeFree |
| Nasopharyngeal cancer recurrent | 0.000271442 | 1 | 0 | BeFree |
| T-cell adult acute lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Acute Undifferentiated Leukemia | 0.000271442 | 1 | 0 | BeFree |
| stage, prostate cancer | 0.000271442 | 1 | 0 | BeFree |
| Mixed Oligodendroglioma-Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of pancreas | 0.000271442 | 1 | 0 | BeFree |
| High-Grade Squamous Intraepithelial Lesions | 0.000271442 | 1 | 0 | BeFree |
| Anaplastic Oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
| Intrahepatic Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of tongue | 0.000271442 | 1 | 0 | BeFree |
| Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
| Lupus Erythematosus | 0.000271442 | 1 | 0 | BeFree |
| ovarian serous tumor | 0.000271442 | 1 | 0 | BeFree |
| Acute myeloid leukemia, minimal differentiation | 0.000271442 | 1 | 0 | BeFree |
| Neurodegenerative Disorders | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
| Tongue Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Ewings sarcoma-primitive neuroectodermal tumor (PNET) | 0.000271442 | 1 | 0 | BeFree |
| Parathyroid Gland Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Primary malignant neoplasm of brain | 0.000271442 | 1 | 0 | BeFree |
| Well Differentiated Oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
| Adult Acute Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukemia secondary | 0.000271442 | 1 | 0 | BeFree |
| Ischemic stroke | 0.000271442 | 1 | 0 | BeFree |
| Colorectal cancer metastatic | 0.000271442 | 1 | 0 | BeFree |
| Nevus cell nevus | 0.000271442 | 1 | 0 | BeFree |
| Atypical teratoid/rhabdoid tumor | 0.000271442 | 1 | 0 | BeFree |
| Low Grade Squamous Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
| Hormone refractory prostate cancer | 0.000271442 | 1 | 0 | BeFree |
| Aggressive Non-Hodgkin Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Primary Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of urinary bladder, superficial | 0.000271442 | 1 | 0 | BeFree |
| Epithelioma | 0.000271442 | 1 | 0 | BeFree |
| Undifferentiated leukemia | 0.000271442 | 1 | 0 | BeFree |
| Primary Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Cholangiolocellular Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Intraductal Papillary-Mucinous Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Tumor Angiogenesis | 0.000271442 | 1 | 0 | BeFree |
| androgen independent prostate cancer | 0.000271442 | 1 | 0 | BeFree |
| Invasive Skin Melanoma | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| MYELOPROLIFERATIVE SYNDROME, TRANSIENT | 0.000271442 | 1 | 0 | BeFree |
| Urothelial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| T-Cell Prolymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Limb ischemia | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary arterial hypertension | 0.000271442 | 1 | 0 | BeFree |
| Early-Stage Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| GASTRIC CANCER, INTESTINAL | 0.000271442 | 1 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 0.000271442 | 1 | 0 | BeFree |
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