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In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  在哺乳动物细胞中,嘌呤脱氧核糖核苷的磷酸化主要是由两个脱氧核糖核苷激酶胞质脱氧胞苷激酶和线粒体脱氧激酶介导的。由该基因编码的蛋白质是负责在线粒体基质嘌呤脱氧核糖核苷的磷酸化。另外,该蛋白质磷酸化在淋巴增生性疾病的治疗中使用的几个嘌呤脱氧核糖核苷类似物,这磷酸化是对类似物的效率是至关重要的。替代剪接变体编码不同蛋白同种型已被用于这个基因说明。 [由RefSeq的,2008年7月提供]
DGUOK基因(以及对应的蛋白质)的细胞分布位置:
DGUOK基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| MITOCHONDRIAL DNA DEPLETION SYNDROME 3 (HEPATOCEREBRAL TYPE) | 0.48 | 2 | 4 | CLINVAR_CTD_human_ORPHANET_UNIPROT |
| Deoxyguanosine Kinase Deficiency | 0.120814326 | 4 | 0 | BeFree_CTD_human |
| Depletion of mitochondrial DNA | 0.003257302 | 12 | 0 | BeFree |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.002367032 | 1 | 1 | GAD |
| Liver Failure | 0.001628651 | 6 | 0 | BeFree |
| Mitochondrial Respiratory Chain Deficiencies | 0.000542884 | 2 | 0 | BeFree |
| Diffuse Cerebral Sclerosis of Schilder | 0.000271442 | 1 | 0 | BeFree |
| Cholestasis | 0.000271442 | 1 | 0 | BeFree |
| leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Lymphocytic, Acute, L1 | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
| Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Myopathy | 0.000271442 | 1 | 0 | BeFree |
| Encephalopathies | 0.000271442 | 1 | 0 | BeFree |
| Mitochondrial Myopathies | 0.000271442 | 1 | 0 | BeFree |
| Chronic progressive external ophthalmoplegia | 0.000271442 | 1 | 0 | BeFree |
| Alpers Syndrome (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Hematologic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| CNS metastases | 0.000271442 | 1 | 0 | BeFree |
| Mitochondrial Diseases | 0.000271442 | 1 | 0 | BeFree |
| Mitochondrial hepatopathy | 0.000271442 | 1 | 0 | BeFree |
| Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
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