更多...
收起
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
[中文简述(自动翻译):]  DEAD盒蛋白,其特征为保守基序天冬氨酸 - 谷氨酸 - 丙氨酸 - 天冬氨酸(DEAD),是推定的RNA解旋酶。它们涉及许多涉及RNA二级结构的改变,如翻译起始,核和线粒体剪接,和核糖体和剪接组件细胞过程。根据他们的分布格局,这个家族的一些成员被认为是参与胚胎发育,精子发生和细胞生长和分裂。该基因编码一个DEAD盒蛋白,它是在果蝇VASA蛋白质和其它几个物种的同源物。该基因是在两种性别和功能在生殖细胞发育的生殖细胞谱系特异性表达。已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的,2009年10月提供]
DDX4基因(以及对应的蛋白质)的细胞分布位置:
DDX4基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| ovarian neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Neuroblastoma | 0.002638474 | 1 | 6 | BeFree_GAD |
| Azoospermia | 0.000271442 | 1 | 0 | BeFree |
| Dysgerminoma | 0.000271442 | 1 | 0 | BeFree |
| Yolk Sac Tumor | 0.000271442 | 1 | 0 | BeFree |
| Male infertility | 0.000271442 | 1 | 0 | BeFree |
| Leydig Cell Tumor | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Oligospermia | 0.000271442 | 1 | 0 | BeFree |
| Seminoma | 0.000271442 | 1 | 0 | BeFree |
| Germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
| Embryonal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Gonadoblastoma | 0.000271442 | 1 | 0 | BeFree |
| Leydig cell tumor, benign | 0.000271442 | 1 | 0 | BeFree |
| Spermatocytic seminoma | 0.000271442 | 1 | 0 | BeFree |
| Congenital bilateral aplasia of vas deferens | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
| Central neuroblastoma | 0.000271442 | 1 | 1 | BeFree |
| Nonseminomatous germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。