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The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The structures of this gene and CYTH1 are very similar. [provided by RefSeq, Aug 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是PSCD家族的一个成员。该家族的成员具有由N-末端卷曲螺旋基序,一个中央Sec7结构域和C-末端普列克底物蛋白同源(PH)结构域的相同的结构组织。卷曲螺旋基序参与同二聚化,该Sec7域包含鸟嘌呤核苷酸交换的蛋白质(GEP)活性,PH结构域与磷脂相互作用并负责与膜PSCDs的关联。这个家庭的成员似乎介导蛋白排序和膜运输的监管。所编码的蛋白质具有GEP活性与两个ARF1和ARF5体外但处于非活动状态与ARF6。此基因和CYTH1的结构非常相似。 [由RefSeq的,2008年8月提供]
CYTH4基因(以及对应的蛋白质)的细胞分布位置:
CYTH4基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Bipolar Disorder | 0.000271442 | 1 | 0 | BeFree |
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