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CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]
[中文简述(自动翻译):]  CTIF是CBP80的一个组成部分(NCBP1; MIM 600469)/ CBP20(NCBP2; MIM 605133)翻译起始的cotranscriptionally结合到新生的mRNA的帽结束复杂。的CBP80 / CBP20复杂涉及同时编辑和翻译步骤,在mRNA的识别提前终止密码子(PTC)的,并指示含有PTC-朝向无义介导降解(NMD)的mRNA。上没有的PTC的mRNA,所述CBP80 / CBP20复合置换细胞质mRNA帽结合蛋白,包括EIF4G(MIM 600495),并在细胞质中恢复的mRNA的稳态翻译(Kim等人,2009 [搜索PubMed 19648179] )[由OMIM,2009年12月提供]
CTIF基因(以及对应的蛋白质)的细胞分布位置:
CTIF基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Parkinson Disease | 0.002367032 | 1 | 1 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
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