CAPNS1(calpain, small subunit 1) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

19q13.1
基因染色体位置图

基因简述

基因简述

This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

[中文简述(自动翻译):]  此基因是钙蛋白酶小亚基家族的一个成员。钙蛋白酶是广泛分布在哺乳动物细胞中钙依赖性半胱氨酸蛋白酶。钙蛋白酶操作为异二聚体，其包含特定的大的催化亚基（钙蛋白酶1亚基在钙蛋白酶I和钙蛋白酶2亚基中钙蛋白酶II），并通过该基因编码一个常见的??小调节亚基。这个编码的蛋白质是两种蛋白酶异二聚体，其蛋白水解活性影响各种细胞功能，包括细胞凋亡，增殖，迁移，粘附和吞噬的稳定性和功能是至关重要的。钙蛋白酶有牵连神经变性过程，如强直性肌营养不良。该基因的假已经1号染色体上多个转录变异体选择性剪接的结果被定义。 [由RefSeq的，2014年10月提供]

OMIM数据库中对CAPNS1基因的介绍     Wikipedia数据库中对CAPNS1基因的介绍

基因序列

基因序列

CAPNS1基因的碱基序列：[NCBI]

基因突变

基因突变

CAPNS1基因的碱基突变：           显示全部snp
rs14100       rs1049339       rs1049643       rs1049657       rs1049720       rs1063408       rs1800650       rs2075475       rs2091825       rs2242525       rs3028991       rs3204449       rs4419170       rs4806281       rs5827950       rs6510524       rs7249866       rs7255180       rs7258813       rs8105099       rs8106210       rs10424687       rs10712025       rs11084845       rs11670293       rs13345186       rs13345512       rs13347141       rs17878462       rs17878466       rs17878485       rs17878500       rs17878680       rs17878701       rs17878728       rs17878750       rs17878759      
rs17878980       rs17879202       rs17879265       rs17879310       rs17879321       rs17879332       rs17879464       rs17879505       rs17879509       rs17879573       rs17879744       rs17879753       rs17879794       rs17879825       rs17880089       rs17880801       rs17880869       rs17880878       rs17880930       rs17881832       rs17881927       rs17881998       rs17882060       rs17882128       rs17882184       rs17882263       rs17882475       rs17882574       rs17882630       rs17882759       rs17884502       rs17884571       rs17884628       rs17884668       rs17884680       rs17884776       rs17884895       rs17884904       rs17885022       rs17885104       rs17885114       rs17885161       rs17885245       rs17885251       rs17885385       rs17886309       rs17886329       rs17886484       rs17886770       rs17887018       rs17887058       rs17887098       rs17887124       rs17887174       rs17887220       rs28623315       rs34859504       rs35133333       rs35391713       rs45574132       rs56909282       rs58509998       rs62111391       rs74172782       rs74172784       rs74172785       rs75117413       rs75478619       rs77138041       rs77202347       rs79014621       rs79995342       rs80318319       rs111468810       rs111556410       rs111666449       rs111902108       rs112093702       rs112180123       rs112192701       rs112340917       rs112429279       rs113297843       rs113501827       rs113520816       rs113634128       rs113710426       rs113794072       rs114474962       rs114646517       rs116114216       rs116751999       rs117814223       rs117900212       rs139054847       rs139109553       rs139934354       rs140132809       rs140322191       rs140368974       rs140469210       rs140628543       rs141098758       rs141290158       rs141310336       rs141365262       rs142640098       rs142663754       rs142758989       rs143521484       rs143627098       rs144188049       rs144454264       rs144504900       rs144819084       rs145117632       rs145363586       rs145502023       rs145631909       rs145643977       rs145937393       rs146564063       rs147176871       rs147734358       rs147924320       rs148900101       rs149264385       rs149318308       rs149654680       rs150221723       rs150662411       rs150877197       rs150977927       rs151248065       rs181136232       rs181751385       rs182191517       rs182242167       rs182304779       rs182404967       rs182875802       rs183373564       rs183617657       rs183706611       rs184294274       rs184528370       rs184889247       rs185151402       rs185320597       rs185600521       rs185939874       rs186547306       rs186878066       rs187032319       rs187336587       rs187950591       rs188025258       rs188165554       rs188235853       rs188595072       rs189227146       rs189256394       rs189789604       rs190077569       rs190601942       rs191020947       rs191470577       rs191480111       rs191836970       rs192313179       rs192316761       rs192531205       rs192957753       rs193096926       rs193272683       rs199834892       rs199893278       rs199916116       rs200239031       rs200391065       rs200436917       rs200464197       rs200941006       rs201371089       rs201399027       rs201667084       rs201700449       rs201727609       rs202081010       rs202135116       rs202205437       rs367609534       rs367819061       rs368617165       rs368705051       rs368762450       rs369323031       rs369741745       rs369952446       rs370009173       rs370319793       rs370410609       rs370505539       rs370858148       rs371056636       rs371312155       rs371819944       rs371931478       rs372305597       rs372416601       rs373284254       rs373683194       rs373692548       rs373765626       rs374045231       rs374053168       rs374131021       rs374159469       rs374566177       rs374645485       rs374973501       rs375019912       rs375584637       rs375764514       rs376339416       rs376730930       rs376949332       rs377244094       rs377344213       rs377390614       rs377720678       rs397805504       rs397859392       rs527243480       rs527325094       rs527406889       rs527746884       rs527786300       rs527839413       rs528340414       rs528399010       rs528629683       rs529342514       rs529858117       rs529876836       rs530403925       rs530419161       rs530687322       rs530767126       rs531334757       rs531775387       rs531786639       rs531821831       rs532133670       rs532505342       rs532627224       rs532809454       rs533395109       rs533809933       rs533860321       rs535099783       rs535107716       rs535283662       rs535622147       rs535788437       rs535926958       rs535964265       rs536204782       rs536534771       rs536597131       rs536693322       rs537407230       rs537597482       rs537949383       rs538122039       rs538158790       rs538528739       rs538969591       rs539020682       rs539725472       rs539826744       rs540068421       rs540344044       rs540933548       rs541508723       rs542488946       rs542489435       rs542620130       rs542688832       rs542696977       rs542727219       rs543006200       rs543701104       rs543879468       rs543881038       rs544159163       rs544855281       rs544870530       rs545598066       rs545898440       rs547114597       rs547291058       rs548059053       rs548074798       rs548324437       rs548432967       rs548771364       rs548957904       rs549050941       rs549066098       rs549095144       rs549269236       rs549818310       rs549840423       rs550053789       rs550124837       rs550304775       rs550584833       rs550791287       rs550951773       rs551085225       rs551087023       rs551330209       rs551575229       rs551877237       rs551914442       rs552040438       rs552179276       rs552436049       rs552521883       rs552603948       rs552637863       rs552894116       rs553052137       rs553538757       rs553595702       rs553614025       rs553816358       rs554722695       rs554943739       rs555594070       rs555630710       rs555674046       rs555674124       rs556086518       rs556143953       rs556409777       rs556686100       rs557241162       rs557590988       rs557850751       rs558032517       rs558069261       rs558466771       rs558893300       rs558912658       rs559066196       rs559140440       rs559995874       rs560042534       rs560134081       rs560207808       rs560501007       rs560511526       rs560742467       rs560846443       rs560922787       rs561088376       rs561551262       rs562006805       rs562043585       rs562715648       rs562840521       rs562924266       rs562947518       rs563083422       rs563512313       rs563647491       rs564099782       rs564244448       rs564284301       rs564751671       rs564883200       rs564907614       rs565156730       rs565273990       rs565464185       rs565520929       rs565682402       rs566458696       rs566739480       rs566936320       rs567322725       rs567464394       rs567500165       rs567535186       rs568481483       rs569029653       rs569284310       rs569288534       rs569340572       rs569423207       rs570838843       rs570998169       rs571086588       rs571405191       rs571956167       rs572077992       rs572236144       rs572239806       rs572946344       rs573082159       rs573104755       rs573403789       rs573728281       rs573869590       rs574159930       rs574948061       rs575077010       rs575112792       rs575211480       rs575809889       rs575818880       rs575949905       rs576077642       rs576498736       rs576561409       rs576579287       rs577226558       rs577362676       rs577783293       rs577884378       rs577973468       rs745343077       rs745696408       rs745917979       rs745995320       rs746032682       rs746519120       rs746788790       rs746841836       rs746891128       rs746893140       rs747082922       rs747083464       rs747422598       rs747694630       rs747745754       rs747945223       rs747968152       rs748021027       rs748144226       rs748228998       rs748576294       rs748746397       rs748784770       rs748839921       rs748860589       rs748893214       rs749076980       rs749370630       rs749529165       rs749576552       rs749603680       rs749681659       rs749738232       rs749740689       rs749907401       rs750134961       rs750141458       rs750191955       rs750234369       rs750436543       rs750505623       rs751028539       rs751032918       rs751035565       rs751275273       rs751284755       rs751366493       rs751647878       rs751850033       rs751878500       rs751905831       rs752226310       rs752459627       rs752673393       rs752750806       rs752829010       rs752972897       rs753035170       rs753084875       rs753361497       rs753773292       rs753892238       rs754177544       rs754181849       rs754371062       rs754629039       rs754928347       rs754973381       rs755060788       rs755115779       rs755338794       rs755375003       rs755390519       rs755984538       rs756080664       rs756136089       rs756139280       rs756246194       rs756299507       rs756542129       rs756870116       rs756889786       rs756919953       rs757028366       rs757089152       rs757119229       rs757448684       rs757745167       rs757803311       rs757838403       rs757940775       rs757969728       rs758016950       rs758316271       rs758474848       rs758630267       rs758659954       rs758731874       rs758750557       rs759047993       rs759073283       rs759165933       rs759403474       rs759454444       rs759505309       rs759700399       rs760228558       rs760228642       rs760281580       rs760373989       rs760381510       rs760532259       rs760597333       rs760886049       rs761088700       rs761276103       rs761305858       rs761386181       rs761502994       rs761541950       rs761751963       rs761900601       rs761953872       rs762231463       rs762406499       rs762515689       rs762675545       rs762877961       rs763020514       rs763065615       rs763365593       rs763394552       rs763416551       rs763540586       rs763604929       rs763794605       rs763841502       rs763944899       rs764274140       rs764310593       rs764319084       rs764736218       rs764833172       rs765107361       rs765239180       rs765290273       rs765770822       rs765805712       rs765986941       rs766025378       rs766042431       rs766140029       rs766196907       rs766388985       rs766442447       rs766542228       rs766969509       rs767071194       rs767124270       rs767181515       rs767355035       rs767610570       rs767808433       rs768047521       rs768321242       rs768372389       rs768400171       rs768429492       rs768612238       rs768613684       rs768772206       rs768785352       rs769050033       rs769099865       rs769151310       rs769252196       rs769415445       rs769735433       rs769782060       rs770031211       rs770148764       rs770182217       rs770259714       rs770314465       rs770343322       rs770407391       rs770790595       rs770862577       rs770908586       rs770936240       rs771258476       rs771307576       rs771384528       rs771481303       rs771831657       rs771976330       rs771995721       rs772001125       rs772216282       rs772591903       rs772620435       rs772660204       rs772807654       rs773012287       rs773120912       rs773174471       rs773176014       rs773292355       rs773523619       rs773608674       rs773804417       rs773857666       rs774127921       rs774196517       rs774331525       rs774586982       rs774705189       rs774766652       rs774804101       rs774886573       rs775042762       rs775165678       rs775310786       rs775353965       rs775372097       rs775496122       rs775549350       rs775808978       rs775851016       rs776025944       rs776082941       rs776109817       rs776215277       rs776222155       rs776517083       rs776601614       rs776822710       rs777036361       rs777067534       rs777291107       rs777474498       rs777534419       rs777676548       rs777995993       rs778012253       rs778193447       rs778415980       rs778499068       rs778505739       rs778696868       rs778850588       rs779013240       rs779024915       rs779030286       rs779155850       rs779190677       rs779361001       rs779646843       rs779823964       rs780013833       rs780060644       rs780186445       rs780223672       rs780325714       rs780414298       rs780529823       rs780531281       rs780575011       rs780788552       rs780842861       rs781100157       rs781432791       rs781574785       rs781699759       rs17885161      

基因表达

基因表达

CAPNS1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
AGTTCCGGAGACTCTTTGC
59
TCTTCAGATCAGGGTGTCG
58
CACAGAGCCAGAGTGAGTC
59
CTCCAAGCACATTTCCCAG
58
CATTACTCCAACATTGAGGACAC
59
AGGCATCACAAGTGCTAGG
59
TACTCCAACATTGAGGACACTC
59
AGGCATCACAAGTGCTAGG
59
CAAACAGTTCGACACTGACC
59
TCATTCAGGTGGAACCCTG
59
CTCCAACATTGAGGACACTC
58
CATGGAGGCATCACAAGTG
58
GTTAACTCGTTCTTGAAGGGC
59
TCATTCAGGTGGAACCCTG
59
AGTTCCGGAGACTCTTTGC
59
TTCAGATCAGGGTGTCGTG
59
CACAGAGCCAGAGTGAGTC
59
CTCCAAGCACATTTCCCAG
58
CTGGTTAACTCGTTCTTGAAGG
59
TCATTCAGGTGGAACCCTG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CAPNS1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

CAPNS1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005509
A0A075B7C0(UniProtKB)
IEA
GO:0006508
A0A075B7C0(UniProtKB)
IEA
GO:0005509
A0A0C4DGQ5(UniProtKB)
IEA
GO:0006508
A0A0C4DGQ5(UniProtKB)
IEA
GO:0005509
K7EIV0(UniProtKB)
IEA
GO:0006508
K7EIV0(UniProtKB)
IEA
GO:0005509
K7EKD8(UniProtKB)
IEA
GO:0006508
K7EKD8(UniProtKB)
IEA
GO:0005509
K7ELJ7(UniProtKB)
IEA
GO:0006508
K7ELJ7(UniProtKB)
IEA
GO:0005509
K7EM73(UniProtKB)
IEA
GO:0006508
K7EM73(UniProtKB)
IEA
GO:0005509
K7EMQ1(UniProtKB)
IEA
GO:0006508
K7EMQ1(UniProtKB)
IEA
GO:0004198
P04632(UniProtKB)
TAS
GO:0005509
P04632(UniProtKB)
IEA
GO:0005515
P04632(UniProtKB)
IPI
GO:0005515
P04632(UniProtKB)
IPI
GO:0005515
P04632(UniProtKB)
IPI
GO:0005515
P04632(UniProtKB)
IPI
GO:0005829
P04632(UniProtKB)
IDA
GO:0005829
P04632(UniProtKB)
TAS
GO:0005886
P04632(UniProtKB)
IEA
GO:0006508
P04632(UniProtKB)
IEA
GO:0008284
P04632(UniProtKB)
TAS
GO:0016020
P04632(UniProtKB)
IDA
GO:0016241
P04632(UniProtKB)
NAS
GO:0022617
P04632(UniProtKB)
TAS
GO:0070062
P04632(UniProtKB)
IDA
GO:0070062
P04632(UniProtKB)
IDA
GO:0005509
U3KPR7(UniProtKB)
IEA
GO:0006508
U3KPR7(UniProtKB)
IEA
GO:0005509
U3KQE2(UniProtKB)
IEA
GO:0006508
U3KQE2(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控CAPNS1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Prostatic Neoplasms 0.12 1 0 CTD_human
Neoplasm Metastasis 0.000814326 3 0 BeFree
Liver carcinoma 0.000814326 3 0 BeFree
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Glioblastoma 0.000271442 1 0 BeFree
Glioma 0.000271442 1 0 BeFree
Liver neoplasms 0.000271442 1 0 BeFree
Lymphatic Metastasis 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
Epstein-Barr Virus Infections 0.000271442 1 0 BeFree
Intrahepatic Cholangiocarcinoma 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
Mammary Carcinoma, Human 0.000271442 1 0 BeFree
Mammary Neoplasms 0.000271442 1 0 BeFree
Nasopharyngeal carcinoma 0.000271442 1 0 BeFree

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