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The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
[中文简述(自动翻译):]  该基因的产物属于丝氨酸/苏氨酸蛋白激酶家族,并以钙(2 +)/钙调蛋白依赖性蛋白激酶亚家族。该基因的主要同种型起着钙/钙调蛋白依赖性(CAM)激酶级联的磷酸化的下游激酶CAMK1和CAMK4作用。此基因的蛋白产物也磷酸化AMP活化蛋白激酶(AMPK)。该基因在大脑和影响信号参与学习和记忆,神经元的分化和迁移,轴突生长和突触形成瀑布的最强表现。在多个转录剪接变异体结果不同编码的亚型。在确定亚型在他们接受自身磷酸化和磷酸化下游激酶的能力有所不同。 [由RefSeq的,2012年7月提供]
CAMKK2基因(以及对应的蛋白质)的细胞分布位置:
CAMKK2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Anxiety Disorders | 0.002367032 | 1 | 0 | GAD |
| Bipolar Disorder | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of prostate | 0.001357209 | 5 | 0 | BeFree |
| Prostate carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Agoraphobia | 0.000271442 | 1 | 2 | BeFree |
| Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
| Obesity | 0.000271442 | 1 | 0 | BeFree |
| Osteoporosis | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
| Stomach Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| Impaired glucose tolerance | 0.000271442 | 1 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Fulminant hepatitis | 0.000271442 | 1 | 0 | BeFree |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Ischemic stroke | 0.000271442 | 1 | 1 | BeFree |
| Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
| Cancer Cell Growth | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Ischemic Cerebrovascular Accident | 0.000271442 | 1 | 1 | BeFree |
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