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This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
[中文简述(自动翻译):]  这个基因是细胞凋亡(IAP)基因家族的抑制剂,其编码与防止细胞凋亡的负调节蛋白的成员。 IAP家族成员通常包含多个杆状病毒IAP重复(BIR)结构域,但这个基因编码的蛋白质仅与单个BIR结构域。编码的蛋白质也缺乏C-末端RING指结构域。基因表达是在成年组织胎儿发育过程中高,在大多数肿瘤中,还低。已发现该基因编码不同亚型选择性剪接转录变异体。 [由RefSeq的,2011年6月提供]
BIRC5基因(以及对应的蛋白质)的细胞分布位置:
BIRC5基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Stomach Neoplasms | 0.221437484 | 10 | 0 | CTD_human_GAD_LHGDN_RGD |
| Liver carcinoma | 0.156482458 | 35 | 0 | BeFree_CTD_human_LHGDN |
| Mammary Neoplasms | 0.150510736 | 15 | 0 | BeFree_CTD_human_LHGDN |
| Lung Neoplasms | 0.144519152 | 11 | 0 | CTD_human_LHGDN |
| Colorectal Neoplasms | 0.136617543 | 7 | 0 | BeFree_CTD_human_LHGDN |
| Colonic Neoplasms | 0.130897401 | 6 | 0 | CTD_human_LHGDN |
| ovarian neoplasm | 0.128173051 | 7 | 0 | CTD_human_LHGDN |
| Renal Cell Carcinoma | 0.126534468 | 7 | 0 | BeFree_CTD_human_LHGDN |
| Myeloid Leukemia, Chronic | 0.12554839 | 6 | 0 | BeFree_CTD_human_GAD |
| Non-Small Cell Lung Carcinoma | 0.124885954 | 18 | 2 | BeFree_CTD_human |
| Adult T-Cell Lymphoma/Leukemia | 0.120814326 | 4 | 0 | BeFree_CTD_human |
| Endometrial Neoplasms | 0.12 | 1 | 0 | CTD_human |
| IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
| Acute Megakaryocytic Leukemias | 0.12 | 1 | 0 | CTD_human |
| Periodontitis | 0.12 | 1 | 1 | GWASCAT |
| Carcinoma, Small Cell | 0.12 | 1 | 0 | CTD_human |
| Glioma | 0.093068936 | 12 | 0 | BeFree_LHGDN_RGD |
| Endometriosis | 0.083267234 | 4 | 0 | BeFree_LHGDN_RGD |
| Heart failure | 0.08 | 1 | 0 | RGD |
| Pulmonary Hypertension | 0.08 | 0 | 0 | RGD |
| Liver Cirrhosis, Experimental | 0.08 | 1 | 0 | RGD |
| Liver Neoplasms, Experimental | 0.08 | 1 | 0 | RGD |
| Myocardial Infarction | 0.08 | 1 | 0 | RGD |
| Reperfusion Injury | 0.08 | 2 | 0 | RGD |
| Pancreatitis, Acute Necrotizing | 0.08 | 1 | 0 | RGD |
| Squamous cell carcinoma | 0.017074551 | 9 | 0 | BeFree_GAD_LHGDN |
| Bladder Neoplasm | 0.013621751 | 5 | 0 | LHGDN |
| Pancreatic Neoplasm | 0.013264433 | 5 | 0 | GAD_LHGDN |
| melanoma | 0.012797494 | 10 | 0 | BeFree_LHGDN |
| leukemia | 0.010897401 | 4 | 0 | LHGDN |
| Prostatic Neoplasms | 0.010897401 | 4 | 0 | LHGDN |
| Infection | 0.010897401 | 4 | 0 | LHGDN |
| Adenocarcinoma | 0.010811525 | 5 | 0 | BeFree_GAD_LHGDN |
| Neuroblastoma | 0.00953026 | 8 | 0 | BeFree_LHGDN |
| Glioblastoma | 0.008173051 | 3 | 0 | LHGDN |
| Malignant neoplasm of lung | 0.007991366 | 13 | 0 | BeFree_GAD |
| Medulloblastoma | 0.005991584 | 3 | 0 | BeFree_LHGDN |
| Esophageal Neoplasms | 0.005634266 | 4 | 0 | BeFree_GAD_LHGDN |
| Cessation of life | 0.0054487 | 2 | 0 | LHGDN |
| Laryngeal neoplasm | 0.0054487 | 2 | 0 | LHGDN |
| Meningioma | 0.0054487 | 2 | 0 | LHGDN |
| Mesothelioma | 0.0054487 | 2 | 0 | LHGDN |
| B-Cell Lymphomas | 0.0054487 | 2 | 0 | LHGDN |
| Small cell carcinoma of lung | 0.0054487 | 2 | 0 | LHGDN |
| Colorectal Cancer | 0.005352893 | 11 | 0 | BeFree_GAD |
| Lymphatic Metastasis | 0.005005506 | 3 | 0 | BeFree_GAD |
| Malignant neoplasm of stomach | 0.004885954 | 18 | 1 | BeFree |
| Breast Carcinoma | 0.004885954 | 18 | 0 | BeFree |
| Stomach Carcinoma | 0.004885954 | 18 | 1 | BeFree |
| Neoplasm Metastasis | 0.004624443 | 8 | 1 | BeFree_LHGDN |
| Malignant neoplasm of breast | 0.00434307 | 16 | 0 | BeFree |
| Lymphoma | 0.003810118 | 5 | 0 | BeFree_LHGDN |
| Colorectal Carcinoma | 0.003528744 | 13 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.003452799 | 4 | 0 | BeFree_GAD |
| Malignant neoplasm of ovary | 0.003452799 | 5 | 0 | BeFree_GAD |
| Multiple Myeloma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Carcinoma of lung | 0.003257302 | 12 | 0 | BeFree |
| Rheumatoid Arthritis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Nasal Polyps | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Thyroid Neoplasm | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Adenoma | 0.00272435 | 1 | 0 | LHGDN |
| Anoxia | 0.00272435 | 1 | 0 | LHGDN |
| Merkel cell carcinoma | 0.00272435 | 1 | 0 | LHGDN |
| Uterine Cervical Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Hepatitis B | 0.00272435 | 1 | 0 | LHGDN |
| Inflammation | 0.00272435 | 1 | 0 | LHGDN |
| Myeloid Leukemia | 0.00272435 | 1 | 0 | LHGDN |
| Leukemia, Myelomonocytic, Chronic | 0.00272435 | 1 | 0 | LHGDN |
| Liver diseases | 0.00272435 | 1 | 0 | LHGDN |
| Lymphoma, Non-Hodgkin | 0.00272435 | 1 | 0 | LHGDN |
| Neoplasms, Germ Cell and Embryonal | 0.00272435 | 1 | 0 | LHGDN |
| Oral Submucous Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
| Pheochromocytoma | 0.00272435 | 1 | 0 | LHGDN |
| Rectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Squamous Cell Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Cardiomyopathies | 0.00272435 | 1 | 0 | LHGDN |
| Primary Effusion Lymphoma | 0.00272435 | 1 | 0 | LHGDN |
| Carcinoma, Transitional Cell | 0.002638474 | 1 | 1 | BeFree_GAD |
| Chronic Lymphocytic Leukemia | 0.002638474 | 2 | 0 | BeFree_GAD |
| Pancreatic carcinoma | 0.002442977 | 9 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.002442977 | 9 | 0 | BeFree |
| Head and Neck Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
| Pathologic Neovascularization | 0.002367032 | 1 | 0 | GAD |
| Urologic Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Neoplasms, Second Primary | 0.002367032 | 1 | 0 | GAD |
| Adenosquamous carcinoma | 0.002367032 | 1 | 0 | GAD |
| Carcinogenesis | 0.002171535 | 8 | 1 | BeFree |
| Cervix carcinoma | 0.001628651 | 6 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.001628651 | 6 | 0 | BeFree |
| Carcinoma of bladder | 0.001628651 | 6 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.001357209 | 5 | 0 | BeFree |
| Malignant tumor of cervix | 0.001357209 | 5 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.001357209 | 5 | 0 | BeFree |
| Ovarian Carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.001357209 | 5 | 1 | BeFree |
| Prostate carcinoma | 0.001357209 | 5 | 1 | BeFree |
| Central neuroblastoma | 0.001357209 | 5 | 0 | BeFree |
| Carcinoma of larynx | 0.001085767 | 4 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.001085767 | 4 | 1 | BeFree |
| Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
| Liver neoplasms | 0.000814326 | 3 | 0 | BeFree |
| Cholangiocarcinoma | 0.000814326 | 3 | 0 | BeFree |
| Endometrial Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000814326 | 3 | 0 | BeFree |
| Colon Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Malignant Peripheral Nerve Sheath Tumor | 0.000814326 | 3 | 0 | BeFree |
| Sarcoma | 0.000814326 | 3 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of endometrium | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, T-Cell | 0.000542884 | 2 | 0 | BeFree |
| oligodendroglioma | 0.000542884 | 2 | 0 | BeFree |
| Adenomatous Polyposis Coli | 0.000542884 | 2 | 0 | BeFree |
| Diffuse Large B-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Benign Neoplasm | 0.000542884 | 2 | 0 | BeFree |
| Esophageal carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| Papillary thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000542884 | 2 | 0 | BeFree |
| Cancer of Head and Neck | 0.000542884 | 2 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Laryngeal Squamous Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of esophagus | 0.000542884 | 2 | 0 | BeFree |
| Malignant Glioma | 0.000542884 | 2 | 0 | BeFree |
| Well Differentiated Oligodendroglioma | 0.000542884 | 2 | 0 | BeFree |
| Uterine Corpus Cancer | 0.000542884 | 2 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Asthma | 0.000271442 | 1 | 0 | BeFree |
| Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cerebral Infarction | 0.000271442 | 1 | 0 | BeFree |
| Chondrosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Cyst | 0.000271442 | 1 | 0 | BeFree |
| HIV Infections | 0.000271442 | 1 | 0 | BeFree |
| Arthropathy | 0.000271442 | 1 | 0 | BeFree |
| Nervous System Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Neurofibromatosis 1 | 0.000271442 | 1 | 0 | BeFree |
| Precancerous Conditions | 0.000271442 | 1 | 0 | BeFree |
| Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
| Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
| Teratoma | 0.000271442 | 1 | 0 | BeFree |
| Thyroid Nodule | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of mouth | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of gallbladder | 0.000271442 | 1 | 0 | BeFree |
| Uterine Cancer | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Intrinsic asthma | 0.000271442 | 1 | 2 | BeFree |
| Cervical Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
| pediatric acute myeloblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Gallbladder Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
| childhood neurofibrosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Anaplastic Oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
| Malignant Mesothelioma of Peritoneum | 0.000271442 | 1 | 0 | BeFree |
| Breast Cancer, Familial | 0.000271442 | 1 | 1 | BeFree |
| Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
| Toxic Shock Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Progressive Neoplastic Disease | 0.000271442 | 1 | 0 | BeFree |
| Refractory cancer | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of kidney | 0.000271442 | 1 | 0 | BeFree |
| Breast adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Ischemic stroke | 0.000271442 | 1 | 0 | BeFree |
| Invasive Ductal Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Endometrial adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Neuroepithelial, Perineurial, and Schwann Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of urinary bladder, superficial | 0.000271442 | 1 | 0 | BeFree |
| Thyroid Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cancer Cell Growth | 0.000271442 | 1 | 0 | BeFree |
| Ischemic Cerebrovascular Accident | 0.000271442 | 1 | 0 | BeFree |
| Progressive cGVHD | 0.000271442 | 1 | 0 | BeFree |
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