BIRC5 (baculoviral IAP repeat containing 5)

基因基本信息

基因基本信息

symbol:
BIRC5
locus group:
protein-coding gene
location:
17q25.3
gene_family:
Baculoviral IAP repeat containing
alias symbol:
EPR-1|survivin
alias name:
None
entrez id:
332
ensembl gene id:
ENSG00000089685
ucsc gene id:
uc002jvg.4
refseq accession:
NM_001168
hgnc_id:
HGNC:593
approved reserved:
1998-06-10

基因染色体位置

基因染色体位置

17q25.3
基因染色体位置图

基因简述

基因简述

BIRC5（也称为存活素或Survivin）属于凋亡抑制蛋白（IAP）基因家族，该家族成员主要通过抑制细胞凋亡来调控细胞存活。BIRC5编码的蛋白是一种重要的抗凋亡因子，在细胞周期调控、有丝分裂和细胞存活中发挥关键作用。它主要在G2/M期表达，通过与有丝分裂纺锤体微管结合，确保染色体正确分离和细胞分裂的顺利进行。BIRC5的表达具有高度组织特异性，通常在胚胎发育中高表达，而在大多数分化成熟的成人组织中表达水平极低或检测不到。然而，在许多癌症（如乳腺癌、肺癌、结肠癌等）中，BIRC5常常异常高表达，这与肿瘤细胞的增殖、侵袭性和耐药性密切相关。BIRC5的突变或表达异常可能导致细胞凋亡受阻，促进肿瘤发生和发展。例如，BIRC5过表达会抑制caspase活性，阻断凋亡信号通路，使癌细胞逃避程序性死亡；同时，它还能通过稳定微管网络促进肿瘤细胞的有丝分裂和迁移。相反，降低BIRC5表达或抑制其功能可诱导肿瘤细胞凋亡，并增强其对化疗和放疗的敏感性。此外，BIRC5在血管生成中也发挥作用，其过表达可能促进肿瘤的血液供应。BIRC5基因家族（IAP家族）的共性是通过BIR（baculovirus IAP repeat）结构域直接结合并抑制caspase，从而调控细胞凋亡。由于其在癌症中的重要作用，BIRC5已成为肿瘤诊断标志物和治疗靶点的研究热点。针对BIRC5的抑制剂（如YM155）或基因沉默策略（如siRNA）在抗癌研究中显示出潜在应用价值。

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

这个基因是细胞凋亡（IAP）基因家族的抑制剂，其编码与防止细胞凋亡的负调节蛋白的成员。 IAP家族成员通常包含多个杆状病毒IAP重复（BIR）结构域，但这个基因编码的蛋白质仅与单个BIR结构域。编码的蛋白质也缺乏C-末端RING指结构域。基因表达是在成年组织胎儿发育过程中高，在大多数肿瘤中，还低。已发现该基因编码不同亚型选择性剪接转录变异体。 [由RefSeq的，2011年6月提供]

OMIM数据库中对BIRC5基因的介绍     Wikipedia数据库中对BIRC5基因的介绍

基因序列

基因序列

BIRC5基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

BIRC5基因的碱基突变：           仅显示部分snp
rs1042489       rs1042541       rs1042542       rs2071214       rs2239680       rs2467572       rs2515815       rs2661684       rs2661685       rs2661686       rs2661687       rs2661688       rs2661689       rs2661690       rs2661691       rs2661692       rs2661693      

基因表达

基因表达

BIRC5基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CTTCTGCTTCAAGGAGCTG
59
TATTACAGGCGTAAGCCAC
57
CTGGACAGAGAAAGAGCCA
59
ACTTTCTCCGCAGTTTCCT
59
CTACATTCAAGAACTGGCCC
59
AAGTCTGGCTCGTTCTCAG
59
ACTGGACAGAGAAAGAGCC
59
CTTTCTCCGCAGTTTCCTC
59
TACATTCAAGAACTGGCCCT
59
AAGTCTGGCTCGTTCTCAG
59
TTGAAACTGGACAGAGAAAGAG
58
TTCATTCTGCTAACAGAGCTC
58
ACATTCAAGAACTGGCCCT
59
AAGTCTGGCTCGTTCTCAG
59
CTGGACAGAGAAAGAGCCA
59
CTTTCTCCGCAGTTTCCTC
59
TTGAAACTGGACAGAGAAAGAG
58
TTCATTCTGCTAACAGAGCT
57

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
APC
BIRC5
Unknown
11751382
CTNNB1
BIRC5
Unknown
19662654; 19778454
DNMT1
BIRC5
Repression
17124180
E2F1
BIRC5
Activation
17848598; 19102934
E2F1
BIRC5
Repression
19102934
E2F1
BIRC5
Unknown
23449974
E2F4
BIRC5
Unknown
18504435
EHMT2
BIRC5
Unknown
17124180
EP300
BIRC5
Activation
19102934
EP300
BIRC5
Repression
19102934

基因本体信息

BIRC5基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

BIRC5基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000226
H3BLT4 (UniProtKB)
IEA
GO:0005737
H3BLT4 (UniProtKB)
IEA
GO:0007346
H3BLT4 (UniProtKB)
IEA
GO:0043524
H3BLT4 (UniProtKB)
IEA
GO:0061178
H3BLT4 (UniProtKB)
IEA
GO:0061469
H3BLT4 (UniProtKB)
IEA
GO:0000086
O15392 (UniProtKB)
IDA
GO:0000228
O15392 (UniProtKB)
IDA
GO:0000775
O15392 (UniProtKB)
IDA
GO:0000775
O15392 (UniProtKB)
IDA
GO:0000775
O15392 (UniProtKB)
IDA
GO:0000775
O15392 (UniProtKB)
IDA
GO:0000777
O15392 (UniProtKB)
IDA
GO:0000910
O15392 (UniProtKB)
IMP
GO:0004842
O15392 (UniProtKB)
IBA
GO:0004869
O15392 (UniProtKB)
IEA
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005515
O15392 (UniProtKB)
IPI
GO:0005634
O15392 (UniProtKB)
IDA
GO:0005634
O15392 (UniProtKB)
IDA
GO:0005654
O15392 (UniProtKB)
TAS
GO:0005654
O15392 (UniProtKB)
TAS
GO:0005737
O15392 (UniProtKB)
IDA
GO:0005737
O15392 (UniProtKB)
IDA
GO:0005737
O15392 (UniProtKB)
IDA
GO:0005814
O15392 (UniProtKB)
IDA
GO:0005819
O15392 (UniProtKB)
IEA
GO:0005829
O15392 (UniProtKB)
IDA
GO:0005829
O15392 (UniProtKB)
IDA
GO:0005829
O15392 (UniProtKB)
TAS
GO:0005829
O15392 (UniProtKB)
TAS
GO:0005829
O15392 (UniProtKB)
TAS
GO:0005829
O15392 (UniProtKB)
TAS
GO:0005829
O15392 (UniProtKB)
TAS
GO:0005829
O15392 (UniProtKB)
TAS
GO:0005829
O15392 (UniProtKB)
TAS
GO:0005829
O15392 (UniProtKB)
TAS
GO:0005829
O15392 (UniProtKB)
TAS
GO:0005829
O15392 (UniProtKB)
TAS
GO:0005829
O15392 (UniProtKB)
TAS
GO:0005874
O15392 (UniProtKB)
IEA
GO:0005876
O15392 (UniProtKB)
IDA
GO:0005876
O15392 (UniProtKB)
IDA
GO:0005881
O15392 (UniProtKB)
IDA
GO:0006351
O15392 (UniProtKB)
IEA
GO:0006468
O15392 (UniProtKB)
IDA
GO:0007062
O15392 (UniProtKB)
TAS
GO:0007067
O15392 (UniProtKB)
TAS
GO:0008017
O15392 (UniProtKB)
TAS
GO:0008017
O15392 (UniProtKB)
IDA
GO:0008270
O15392 (UniProtKB)
IDA
GO:0008270
O15392 (UniProtKB)
NAS
GO:0008284
O15392 (UniProtKB)
TAS
GO:0008536
O15392 (UniProtKB)
IPI
GO:0009966
O15392 (UniProtKB)
IBA
GO:0015631
O15392 (UniProtKB)
IDA
GO:0016567
O15392 (UniProtKB)
IEA
GO:0016925
O15392 (UniProtKB)
TAS
GO:0019899
O15392 (UniProtKB)
IPI
GO:0030496
O15392 (UniProtKB)
IDA
GO:0030496
O15392 (UniProtKB)
IDA
GO:0030496
O15392 (UniProtKB)
IDA
GO:0030496
O15392 (UniProtKB)
IDA
GO:0030496
O15392 (UniProtKB)
IDA
GO:0031021
O15392 (UniProtKB)
IDA
GO:0031503
O15392 (UniProtKB)
IMP
GO:0031536
O15392 (UniProtKB)
IMP
GO:0031577
O15392 (UniProtKB)
IMP
GO:0032133
O15392 (UniProtKB)
IPI
GO:0032133
O15392 (UniProtKB)
IPI
GO:0032133
O15392 (UniProtKB)
IPI
GO:0042802
O15392 (UniProtKB)
IPI
GO:0042802
O15392 (UniProtKB)
IPI
GO:0042802
O15392 (UniProtKB)
IPI
GO:0042803
O15392 (UniProtKB)
IDA
GO:0042803
O15392 (UniProtKB)
IDA
GO:0042803
O15392 (UniProtKB)
IPI
GO:0042981
O15392 (UniProtKB)
TAS
GO:0043027
O15392 (UniProtKB)
IMP
GO:0043066
O15392 (UniProtKB)
IDA
GO:0043066
O15392 (UniProtKB)
IDA
GO:0043066
O15392 (UniProtKB)
IDA
GO:0043066
O15392 (UniProtKB)
IMP
GO:0043066
O15392 (UniProtKB)
IDA
GO:0043066
O15392 (UniProtKB)
IDA
GO:0043154
O15392 (UniProtKB)
IDA
GO:0043154
O15392 (UniProtKB)
IMP
GO:0045892
O15392 (UniProtKB)
IMP
GO:0045931
O15392 (UniProtKB)
IMP
GO:0046872
O15392 (UniProtKB)
IEA
GO:0046982
O15392 (UniProtKB)
IDA
GO:0046982
O15392 (UniProtKB)
IDA
GO:0048037
O15392 (UniProtKB)
IDA
GO:0050897
O15392 (UniProtKB)
NAS
GO:0051087
O15392 (UniProtKB)
IPI
GO:0051301
O15392 (UniProtKB)
IEA
GO:0051301
O15392 (UniProtKB)
IMP
GO:0051303
O15392 (UniProtKB)
IMP
GO:0090307
O15392 (UniProtKB)
IBA
GO:1990001
O15392 (UniProtKB)
IBA

基因相关microRNA

基因相关microRNA

可能调控 BIRC5基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Stomach Neoplasms 0.221437484 10 0 CTD_human_GAD_LHGDN_RGD
Liver carcinoma 0.156482458 35 0 BeFree_CTD_human_LHGDN
Mammary Neoplasms 0.150510736 15 0 BeFree_CTD_human_LHGDN
Lung Neoplasms 0.144519152 11 0 CTD_human_LHGDN
Colorectal Neoplasms 0.136617543 7 0 BeFree_CTD_human_LHGDN
Colonic Neoplasms 0.130897401 6 0 CTD_human_LHGDN
ovarian neoplasm 0.128173051 7 0 CTD_human_LHGDN
Renal Cell Carcinoma 0.126534468 7 0 BeFree_CTD_human_LHGDN
Myeloid Leukemia, Chronic 0.12554839 6 0 BeFree_CTD_human_GAD
Non-Small Cell Lung Carcinoma 0.124885954 18 2 BeFree_CTD_human

基因相关服务

基因相关服务

联系方式

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