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This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  此基因在黏膜相关淋巴组织(MALT)淋巴瘤的情况下识别通过其易位。由该基因编码的蛋白质包含胱天蛋白酶募集结构域(CARD),并且已经显示出诱导细胞凋亡并激活NF-κB的。这种蛋白质据报道与其它含CARD结构域蛋白,包括CARD9,10,11和14,这被认为是在NF-κB的信号充当上游调节相互作用。这种蛋白质被发现以形成具有MALT1,通过公知的在MALT淋巴瘤被易位另一个基因编码的蛋白质的复合物。 MALT1和该蛋白被认为是在NF-κB的活化,以协同,并且其中一方的失调可向相同致病过程,导致恶性肿瘤。 [由RefSeq的,2008年7月提供]
BCL10基因(以及对应的蛋白质)的细胞分布位置:
BCL10基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Mucosa-Associated Lymphoid Tissue Lymphoma | 0.149636822 | 61 | 3 | BeFree_CLINVAR_LHGDN |
| Lymphoma, Follicular | 0.122909916 | 3 | 6 | BeFree_CLINVAR_GAD |
| Malignant neoplasm of testis | 0.122367032 | 1 | 1 | CLINVAR_GAD |
| Mesothelioma | 0.120542884 | 2 | 2 | BeFree_CLINVAR |
| Colon Carcinoma | 0.120542884 | 2 | 1 | BeFree_CLINVAR |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.120271442 | 1 | 1 | BeFree_CLINVAR |
| Sezary Syndrome | 0.12 | 0 | 1 | CLINVAR |
| Lymphoma | 0.014416214 | 25 | 0 | BeFree_LHGDN |
| B-Cell Lymphomas | 0.008891568 | 16 | 0 | BeFree_GAD_LHGDN |
| Diffuse Large B-Cell Lymphoma | 0.003452799 | 5 | 0 | BeFree_GAD |
| ovarian neoplasm | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Mammary Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| T-Cell Lymphoma | 0.00272435 | 1 | 0 | LHGDN |
| Liver carcinoma | 0.002714419 | 10 | 0 | BeFree |
| Multiple Sclerosis | 0.002638474 | 2 | 1 | BeFree_GAD |
| Solid tumour | 0.002171535 | 8 | 0 | BeFree |
| Colorectal Carcinoma | 0.001628651 | 6 | 0 | BeFree |
| Ovarian Carcinoma | 0.001628651 | 6 | 0 | BeFree |
| Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.001628651 | 6 | 0 | BeFree |
| Multiple Myeloma | 0.001357209 | 5 | 0 | BeFree |
| Tumor Progression | 0.001357209 | 5 | 0 | BeFree |
| Carcinogenesis | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.001357209 | 5 | 0 | BeFree |
| Colorectal Cancer | 0.001357209 | 5 | 0 | BeFree |
| leukemia | 0.001085767 | 4 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.001085767 | 4 | 0 | BeFree |
| Myeloid Leukemia, Chronic | 0.001085767 | 4 | 0 | BeFree |
| Esophageal carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Germ cell tumor | 0.001085767 | 4 | 0 | BeFree |
| Pancreatic carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Epithelial ovarian cancer | 0.001085767 | 4 | 0 | BeFree |
| Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Gastric Mucosa-Associated Lymphoid Tissue Lymphoma | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
| Squamous cell carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000814326 | 3 | 0 | BeFree |
| Squamous cell carcinoma of esophagus | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000814326 | 3 | 0 | BeFree |
| Leukemogenesis | 0.000814326 | 3 | 0 | BeFree |
| Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Marginal Zone B-Cell Lymphoma | 0.000814326 | 3 | 0 | BeFree |
| Malignant tumor of colon | 0.000542884 | 2 | 0 | BeFree |
| Congenital chromosomal disease | 0.000542884 | 2 | 0 | BeFree |
| Esophageal Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Glioma | 0.000542884 | 2 | 0 | BeFree |
| HIV Infections | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, Lymphocytic, Acute, L1 | 0.000542884 | 2 | 0 | BeFree |
| melanoma | 0.000542884 | 2 | 0 | BeFree |
| Pheochromocytoma | 0.000542884 | 2 | 0 | BeFree |
| Plasmacytoma | 0.000542884 | 2 | 0 | BeFree |
| Small cell carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
| Ki-1+ Anaplastic Large Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Cervix carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
| Hematologic Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Plasma cell tumor, malignant | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of esophagus | 0.000542884 | 2 | 0 | BeFree |
| Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000542884 | 2 | 0 | BeFree |
| Sarcoma | 0.000542884 | 2 | 0 | BeFree |
| Plasma Cell Neoplasm | 0.000542884 | 2 | 0 | BeFree |
| Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Amyotrophic Lateral Sclerosis | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Diabetes | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
| Gastritis | 0.000271442 | 1 | 0 | BeFree |
| Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
| Kidney Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Leprosy | 0.000271442 | 1 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Acute Megakaryocytic Leukemias | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Plasma Cell | 0.000271442 | 1 | 0 | BeFree |
| Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Primary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
| Spinal Muscular Atrophy | 0.000271442 | 1 | 0 | BeFree |
| Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
| Thyroiditis | 0.000271442 | 1 | 0 | BeFree |
| Trisomy | 0.000271442 | 1 | 0 | BeFree |
| Peripheral T-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Li-Fraumeni Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of mouth | 0.000271442 | 1 | 0 | BeFree |
| Adenomatous Polyps | 0.000271442 | 1 | 0 | BeFree |
| Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Malignant mesothelioma | 0.000271442 | 1 | 0 | BeFree |
| Follicular neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Endometrial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Combined immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Lymphoid neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| gastritis h pylori | 0.000271442 | 1 | 0 | BeFree |
| Overnutrition | 0.000271442 | 1 | 0 | BeFree |
| Basaloid squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Primary cutaneous marginal zone B-cell lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Liver regeneration disorder | 0.000271442 | 1 | 0 | BeFree |
| Testicular Germ Cell Tumor | 0.000271442 | 1 | 0 | BeFree |
| T-Cell Prolymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
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