BCL10 (BCL10 immune signaling adaptor)

基因基本信息

基因基本信息

symbol:
BCL10
locus group:
protein-coding gene
location:
1p22.3
gene_family:
alias symbol:
CARMEN|CIPER|mE10|c-E10|CLAP
alias name:
CARD-like apoptotic protein|CARD-c…
entrez id:
8915
ensembl gene id:
ENSG00000142867
ucsc gene id:
uc021opd.3
refseq accession:
NM_003921
hgnc_id:
HGNC:989
approved reserved:
1999-01-08

基因染色体位置

基因染色体位置

1p22.3
基因染色体位置图

基因简述

基因简述

BCL10（B细胞淋巴瘤10）是一种重要的基因，编码一种参与免疫信号传导的蛋白质，主要与NF-κB信号通路的激活相关。它在B细胞和T细胞的发育、增殖以及免疫应答中发挥关键作用。BCL10蛋白通过CARD（caspase募集结构域）与其他蛋白质（如MALT1和CARD11）相互作用，形成信号复合物，从而激活NF-κB，促进细胞存活和炎症反应。BCL10的突变或异常表达可能导致免疫系统功能紊乱，并与多种疾病相关，特别是淋巴瘤（如黏膜相关淋巴组织淋巴瘤，MALT淋巴瘤）和免疫缺陷疾病。某些染色体易位（如t(1;14)）会导致BCL10过表达，进而异常激活NF-κB，促进肿瘤发生。相反，BCL10表达降低可能削弱免疫细胞的功能，导致免疫应答不足。BCL10属于CARD家族基因，该家族成员通常含有CARD结构域，参与细胞凋亡、炎症和免疫调节的信号传导。CARD家族蛋白的共同特点是能够通过同型相互作用形成复合物，调控下游信号通路。BCL10的异常表达不仅影响自身功能，还可能干扰其他CARD家族成员（如CARD11或CARD9）的活性，从而影响整体免疫平衡。因此，BCL10在免疫调节和疾病发生中具有重要作用，其表达水平的精确调控对维持机体健康至关重要。

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]

此基因在黏膜相关淋巴组织（MALT）淋巴瘤的情况下识别通过其易位。由该基因编码的蛋白质包含胱天蛋白酶募集结构域（CARD），并且已经显示出诱导细胞凋亡并激活NF-κB的。这种蛋白质据报道与其它含CARD结构域蛋白，包括CARD9，10，11和14，这被认为是在NF-κB的信号充当上游调节相互作用。这种蛋白质被发现以形成具有MALT1，通过公知的在MALT淋巴瘤被易位另一个基因编码的蛋白质的复合物。 MALT1和该蛋白被认为是在NF-κB的活化，以协同，并且其中一方的失调可向相同致病过程，导致恶性肿瘤。 [由RefSeq的，2008年7月提供]

OMIM数据库中对BCL10基因的介绍     Wikipedia数据库中对BCL10基因的介绍

基因序列

基因序列

BCL10基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

BCL10基因的碱基突变：           仅显示部分snp
rs962409       rs1060843       rs1060846       rs1141360       rs1474496       rs1802445       rs2252408       rs2647396       rs2735588       rs2735589       rs2735590       rs2735591       rs2735592       rs2735593       rs2735594       rs2735595       rs3768233      

基因表达

基因表达

BCL10基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CATCTGAAAGATGGAGCCAC
59
GTACATGACAGTGGATGCC
58
GAAGTGAAGAAGGACGCCT
60
CTTCAGTGTCTTCTCTACTGAG
58
TCTGAAAGATGGAGCCACG
59
TACATGACAGTGGATGCCC
59
CATCTGAAAGATGGAGCCAC
59
TACATGACAGTGGATGCCC
60
GAAGTGAAGAAGGACGCCT
59
TTCTTCAGTGTCTTCTCTACTGAG
59
GAAGTGAAGAAGGACGCCT
60
TTCTTCAGTGTCTTCTCTACTGAG
60
GAAGTGAAGAAGGACGCCT
60
TCTTCAGTGTCTTCTCTACTGAG
59
TCTGAAAGATGGAGCCACG
60
TACATGACAGTGGATGCCC
60
GAAGTGAAGAAGGACGCCT
59
TCTTCAGTGTCTTCTCTACTGAG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

BCL10基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

BCL10基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0006915
A0A087WWW9 (UniProtKB)
IEA
GO:0042981
A0A087WWW9 (UniProtKB)
IEA
GO:0051092
A0A087WWW9 (UniProtKB)
IEA
GO:0001772
O95999 (UniProtKB)
IEA
GO:0001783
O95999 (UniProtKB)
IEA
GO:0001843
O95999 (UniProtKB)
ISS
GO:0002020
O95999 (UniProtKB)
IPI
GO:0002223
O95999 (UniProtKB)
TAS
GO:0002224
O95999 (UniProtKB)
IC
GO:0002237
O95999 (UniProtKB)
IEP
GO:0002250
O95999 (UniProtKB)
TAS
GO:0002250
O95999 (UniProtKB)
IMP
GO:0002906
O95999 (UniProtKB)
IDA
GO:0003713
O95999 (UniProtKB)
IDA
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005515
O95999 (UniProtKB)
IPI
GO:0005634
O95999 (UniProtKB)
IDA
GO:0005737
O95999 (UniProtKB)
IDA
GO:0005737
O95999 (UniProtKB)
IDA
GO:0005737
O95999 (UniProtKB)
IDA
GO:0005737
O95999 (UniProtKB)
IDA
GO:0005764
O95999 (UniProtKB)
IDA
GO:0005829
O95999 (UniProtKB)
IDA
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005829
O95999 (UniProtKB)
TAS
GO:0005881
O95999 (UniProtKB)
IDA
GO:0005886
O95999 (UniProtKB)
TAS
GO:0006968
O95999 (UniProtKB)
IEA
GO:0007249
O95999 (UniProtKB)
IEA
GO:0008022
O95999 (UniProtKB)
IPI
GO:0008134
O95999 (UniProtKB)
IPI
GO:0008219
O95999 (UniProtKB)
IDA
GO:0009620
O95999 (UniProtKB)
IEA
GO:0016064
O95999 (UniProtKB)
IEA
GO:0019899
O95999 (UniProtKB)
IPI
GO:0019900
O95999 (UniProtKB)
IPI
GO:0019900
O95999 (UniProtKB)
IPI
GO:0019901
O95999 (UniProtKB)
IDA
GO:0031398
O95999 (UniProtKB)
IDA
GO:0031625
O95999 (UniProtKB)
IPI
GO:0032094
O95999 (UniProtKB)
IDA
GO:0032449
O95999 (UniProtKB)
NAS
GO:0032765
O95999 (UniProtKB)
NAS
GO:0038095
O95999 (UniProtKB)
TAS
GO:0042109
O95999 (UniProtKB)
NAS
GO:0042226
O95999 (UniProtKB)
NAS
GO:0042327
O95999 (UniProtKB)
IDA
GO:0043123
O95999 (UniProtKB)
IEP
GO:0043130
O95999 (UniProtKB)
IDA
GO:0043234
O95999 (UniProtKB)
IDA
GO:0043234
O95999 (UniProtKB)
IDA
GO:0043280
O95999 (UniProtKB)
IEA
GO:0043422
O95999 (UniProtKB)
IPI
GO:0043621
O95999 (UniProtKB)
IPI
GO:0045087
O95999 (UniProtKB)
IEP
GO:0045121
O95999 (UniProtKB)
IEA
GO:0045416
O95999 (UniProtKB)
IMP
GO:0045893
O95999 (UniProtKB)
IDA
GO:0048471
O95999 (UniProtKB)
IDA
GO:0050852
O95999 (UniProtKB)
IDA
GO:0050852
O95999 (UniProtKB)
TAS
GO:0050856
O95999 (UniProtKB)
IEA
GO:0050870
O95999 (UniProtKB)
IEA
GO:0051059
O95999 (UniProtKB)
IDA
GO:0051092
O95999 (UniProtKB)
IDA
GO:0051092
O95999 (UniProtKB)
IDA
GO:0051259
O95999 (UniProtKB)
IPI
GO:0051260
O95999 (UniProtKB)
ISS
GO:0051260
O95999 (UniProtKB)
TAS
GO:0051291
O95999 (UniProtKB)
IEA
GO:0070231
O95999 (UniProtKB)
IEA
GO:0071260
O95999 (UniProtKB)
IEP
GO:2001238
O95999 (UniProtKB)
IDA
GO:0042101
O95999 (UniProtKB)
IDA
GO:0046696
O95999 (UniProtKB)
IDA
GO:0019209
O95999 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 BCL10基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Mucosa-Associated Lymphoid Tissue Lymphoma 0.149636822 61 3 BeFree_CLINVAR_LHGDN
Lymphoma, Follicular 0.122909916 3 6 BeFree_CLINVAR_GAD
Malignant neoplasm of testis 0.122367032 1 1 CLINVAR_GAD
Colon Carcinoma 0.120542884 2 1 BeFree_CLINVAR
Mesothelioma 0.120542884 2 2 BeFree_CLINVAR
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 0.120271442 1 1 BeFree_CLINVAR
Sezary Syndrome 0.12 0 1 CLINVAR
Lymphoma 0.014416214 25 0 BeFree_LHGDN
B-Cell Lymphomas 0.008891568 16 0 BeFree_GAD_LHGDN
Diffuse Large B-Cell Lymphoma 0.003452799 5 0 BeFree_GAD

基因相关服务

基因相关服务

联系方式

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