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This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. [provided by RefSeq, Jan 2009]
[中文简述(自动翻译):]  该基因是基于同源性的巴斯德毕赤酵母GSA7和酿酒酵母APG7识别。在酵母中,蛋白质似乎是必需的过氧化物酶体和液泡膜的融合。该蛋白质显示同源性的E1的泛素激活酶的ATP结合和催化位点。 [由RefSeq的,2009年1月提供]
ATG7基因(以及对应的蛋白质)的细胞分布位置:
ATG7基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Anemia | 0.12 | 1 | 0 | CTD_human |
| Lethargy | 0.12 | 1 | 0 | CTD_human |
| Lymphopenia | 0.12 | 1 | 0 | CTD_human |
| Necrosis | 0.12 | 1 | 0 | CTD_human |
| Weight decreased | 0.12 | 1 | 0 | CTD_human |
| PARKINSON DISEASE, LATE-ONSET | 0.08 | 0 | 0 | MGD |
| MYELODYSPLASTIC SYNDROME | 0.08 | 0 | 0 | MGD |
| Huntington Disease | 0.002638474 | 2 | 0 | BeFree_GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Chronic progressive chorea | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of lung | 0.000814326 | 3 | 0 | BeFree |
| Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
| Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Adenocarcinoma | 0.000542884 | 2 | 1 | BeFree |
| Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
| Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Asthma | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Acute Promyelocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Seizures | 0.000271442 | 1 | 0 | BeFree |
| Tremor | 0.000271442 | 1 | 0 | BeFree |
| Retinal damage | 0.000271442 | 1 | 0 | BeFree |
| Gastrointestinal Stromal Tumors | 0.000271442 | 1 | 0 | BeFree |
| Anaplastic thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Childhood asthma | 0.000271442 | 1 | 0 | BeFree |
| Conventional (Clear Cell) Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Necrotizing Enterocolitis | 0.000271442 | 1 | 0 | BeFree |
| Metabolic Syndrome X | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Lewy Body Disease | 0.000271442 | 1 | 0 | BeFree |
| Hurthle Cell Tumor | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Promyelocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Vacuolar myopathy | 0.000271442 | 1 | 0 | BeFree |
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