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This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]
[中文简述(自动翻译):] 这种蛋白质属于醛脱氢酶家族的蛋白质。醛脱氢酶是醇代谢的主要氧化途径的第二个酶。醛脱氢酶,胞质和线粒体的两个主要的肝同种型,可以通过它们的电泳迁移率,动力学性质,和亚细胞定位进行区分。最白种人有两个主要的同功酶,而东方人的约50%具有胞质同工酶但不是线粒体同工酶。东方人比白种人之间的急性酒精中毒的一个显着更高的频率可能与缺乏线粒体同工酶的催化活性的形式。曝光增加到乙醛个体与无催化活性的形式也可以赋予更大的易感性许多类型的癌症。这个基因编码的线粒体同种型,其具有低的公里为乙醛,和在线粒体基质被定位。在多个转录剪接变异体导致不同的编码亚型。[由RefSeq的,2011年3月提供]
ALDH2基因(以及对应的蛋白质)的细胞分布位置:
ALDH2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Alcoholic Intoxication, Chronic | 0.470944373 | 141 | 3 | BeFree_CLINVAR_CTD_human_GAD_GWASCAT |
ALCOHOL SENSITIVITY, ACUTE | 0.24 | 1 | 1 | CLINVAR_CTD_human |
Esophageal Neoplasms | 0.214123245 | 60 | 1 | BeFree_CTD_human_GAD_LHGDN |
Malignant neoplasm of esophagus | 0.175092902 | 54 | 1 | BeFree_GAD_GWASCAT |
Flushing | 0.15743791 | 48 | 1 | BeFree_CTD_human_GAD |
Coronary heart disease | 0.128729747 | 10 | 1 | BeFree_GAD_GWASCAT |
Colorectal Neoplasms | 0.127815732 | 3 | 0 | CTD_human_GAD_LHGDN |
Asthma | 0.126091273 | 6 | 0 | BeFree_CTD_human_GAD |
Squamous cell carcinoma of esophagus | 0.125971721 | 22 | 4 | BeFree_CTD_human |
Precancerous Conditions | 0.122367032 | 2 | 0 | CTD_human_GAD |
Cerebrovascular accident | 0.121357209 | 6 | 2 | BeFree_GWASCAT |
Male infertility | 0.12 | 1 | 0 | CTD_human |
Liver Cirrhosis, Experimental | 0.12 | 1 | 0 | CTD_human |
Dermatitis, Occupational | 0.12 | 1 | 0 | CTD_human |
Vascular Diseases | 0.12 | 1 | 0 | CTD_human |
Ventricular Dysfunction | 0.12 | 1 | 0 | CTD_human |
Complications of Diabetes Mellitus | 0.12 | 1 | 0 | CTD_human |
Necrotizing Enterocolitis | 0.12 | 1 | 0 | CTD_human |
HANGOVER, SUSCEPTIBILITY TO (finding) | 0.12 | 0 | 1 | CLINVAR |
SUBLINGUAL NITROGLYCERIN, SUSCEPTIBILITY TO POOR RESPONSE TO | 0.12 | 0 | 1 | CLINVAR |
Myocardial Ischemia | 0.081085767 | 5 | 0 | BeFree_RGD |
Heart Diseases | 0.080271442 | 2 | 0 | BeFree_RGD |
Fatty Liver, Alcoholic | 0.08 | 1 | 0 | RGD |
Myocardial Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Drug-Induced Liver Injury | 0.08 | 1 | 0 | RGD |
Squamous cell carcinoma | 0.058042544 | 22 | 0 | BeFree_GAD_LHGDN |
Alcohol abuse | 0.027666003 | 17 | 3 | BeFree_GAD |
Hypertensive disease | 0.027013499 | 17 | 0 | BeFree_GAD_LHGDN |
Colorectal Cancer | 0.024832032 | 16 | 3 | BeFree_GAD |
Alcoholic Liver Diseases | 0.019912403 | 16 | 0 | BeFree_GAD_LHGDN |
Liver carcinoma | 0.015264215 | 10 | 0 | BeFree_GAD_LHGDN |
Head and Neck Neoplasms | 0.014202192 | 6 | 0 | GAD |
Malignant neoplasm of lung | 0.012649486 | 5 | 0 | BeFree_GAD |
Esophageal carcinoma | 0.012486326 | 46 | 1 | BeFree |
Myocardial Infarction | 0.012268423 | 10 | 1 | BeFree_GAD_LHGDN |
Pancreatitis, Alcoholic | 0.010825337 | 9 | 0 | BeFree_GAD |
Alzheimer's Disease | 0.009825446 | 4 | 0 | GAD_LHGDN |
Liver Cirrhosis | 0.009544073 | 10 | 0 | BeFree_GAD |
Laryngeal neoplasm | 0.009468128 | 4 | 0 | GAD |
Mouth Neoplasms | 0.009468128 | 4 | 0 | GAD |
Pharyngeal Neoplasms | 0.009468128 | 4 | 0 | GAD |
Systemic arterial pressure | 0.009468128 | 4 | 0 | GAD |
Liver diseases | 0.008544182 | 7 | 0 | BeFree_GAD_LHGDN |
Malignant neoplasm of stomach | 0.00853425 | 15 | 1 | BeFree_GAD |
Liver Cirrhosis, Alcoholic | 0.008458305 | 7 | 0 | BeFree_GAD |
Diabetes Mellitus, Non-Insulin-Dependent | 0.008186863 | 6 | 0 | BeFree_GAD |
Alcohol-Related Disorders | 0.008186863 | 7 | 0 | BeFree_GAD |
Liver neoplasms | 0.00764398 | 5 | 0 | BeFree_GAD |
Malignant neoplasm of breast | 0.007372538 | 3 | 0 | BeFree_GAD |
Cancer of Head and Neck | 0.007177041 | 10 | 4 | BeFree_GAD |
Coronary Artery Disease | 0.007177041 | 9 | 1 | BeFree_GAD |
As If Personality | 0.007101096 | 3 | 0 | GAD |
Pancreatitis | 0.007101096 | 3 | 0 | GAD |
Diabetes Mellitus | 0.006362715 | 6 | 3 | BeFree_GAD |
Pancreatitis, Chronic | 0.00617715 | 5 | 0 | BeFree_GAD_LHGDN |
Alcoholic Intoxication | 0.006091273 | 7 | 0 | BeFree_GAD |
Alcoholic Neuropathy | 0.005634266 | 2 | 0 | BeFree_GAD_LHGDN |
Lung Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Adenoma | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
Atherosclerosis | 0.005276948 | 3 | 0 | BeFree_GAD |
Periodontitis | 0.005276948 | 2 | 0 | BeFree_GAD |
Diabetes Mellitus, Insulin-Dependent | 0.005091382 | 2 | 0 | GAD_LHGDN |
Pancreatic Neoplasm | 0.005091382 | 2 | 0 | GAD_LHGDN |
Cardiovascular Diseases | 0.004810009 | 10 | 0 | BeFree_GAD |
Cocarcinogenesis | 0.004734064 | 2 | 0 | GAD |
Colonic Neoplasms | 0.004734064 | 2 | 0 | GAD |
DNA Damage | 0.004734064 | 2 | 0 | GAD |
Oropharyngeal Neoplasms | 0.004734064 | 2 | 0 | GAD |
Bone necrosis | 0.004734064 | 2 | 0 | GAD |
Rectal Neoplasms | 0.004734064 | 2 | 0 | GAD |
Cirrhosis | 0.003995683 | 7 | 0 | BeFree_GAD |
heavy drinking | 0.003800186 | 14 | 0 | BeFree |
Stomach Carcinoma | 0.003800186 | 14 | 1 | BeFree |
Colorectal Carcinoma | 0.003528744 | 13 | 3 | BeFree |
Melanosis | 0.003181358 | 3 | 0 | BeFree_GAD |
Gastritis, Atrophic | 0.002909916 | 3 | 0 | BeFree_GAD |
Chronic Obstructive Airway Disease | 0.002909916 | 3 | 0 | BeFree_GAD |
Stomach Neoplasms | 0.002638474 | 2 | 0 | BeFree_GAD |
Metabolic Syndrome X | 0.002638474 | 1 | 0 | BeFree_GAD |
Coronary Arteriosclerosis | 0.002442977 | 9 | 1 | BeFree |
Angina Pectoris | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
Intracranial Aneurysm | 0.002367032 | 1 | 1 | GAD |
Colonic Polyps | 0.002367032 | 1 | 0 | GAD |
Digestive System Neoplasms | 0.002367032 | 1 | 0 | GAD |
Drug Allergy | 0.002367032 | 1 | 0 | GAD |
Ectodermal Dysplasia | 0.002367032 | 1 | 0 | GAD |
Gastrointestinal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Hypersensitivity | 0.002367032 | 1 | 0 | GAD |
Kidney Failure, Chronic | 0.002367032 | 1 | 1 | GAD |
Mesothelioma | 0.002367032 | 1 | 0 | GAD |
Metaplasia | 0.002367032 | 1 | 0 | GAD |
Neoplasm Invasiveness | 0.002367032 | 1 | 0 | GAD |
Neoplasm Metastasis | 0.002367032 | 1 | 0 | GAD |
Obesity | 0.002367032 | 1 | 0 | GAD |
Occupational Diseases | 0.002367032 | 1 | 0 | GAD |
Parkinson Disease | 0.002367032 | 1 | 0 | GAD |
Peptic Ulcer | 0.002367032 | 1 | 0 | GAD |
Periodontal Pocket | 0.002367032 | 1 | 0 | GAD |
Pleural Neoplasms | 0.002367032 | 1 | 0 | GAD |
Retinopathy of Prematurity | 0.002367032 | 1 | 0 | GAD |
Stomach Diseases | 0.002367032 | 1 | 0 | GAD |
Substance Withdrawal Syndrome | 0.002367032 | 1 | 0 | GAD |
Unconscious State | 0.002367032 | 1 | 0 | GAD |
Helicobacter Infections | 0.002367032 | 1 | 0 | GAD |
Neoplasms, Second Primary | 0.002367032 | 1 | 0 | GAD |
Premature Birth | 0.002367032 | 1 | 0 | GAD |
Adenomatous Polyps | 0.002367032 | 1 | 0 | GAD |
Squamous Cell Neoplasms | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of prostate | 0.002367032 | 1 | 0 | GAD |
Genomic Instability | 0.002367032 | 1 | 0 | GAD |
Stroke, Lacunar | 0.002367032 | 1 | 0 | GAD |
Carcinogenesis | 0.002171535 | 8 | 1 | BeFree |
alcohol use disorder | 0.001900093 | 7 | 0 | BeFree |
Diabetes | 0.001357209 | 5 | 2 | BeFree |
Pancreatic carcinoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.001357209 | 5 | 0 | BeFree |
alcohol flush reaction | 0.001357209 | 5 | 0 | BeFree |
Ischemia | 0.001085767 | 4 | 0 | BeFree |
Essential Hypertension | 0.001085767 | 4 | 1 | BeFree |
Macrocytosis | 0.001085767 | 4 | 0 | BeFree |
Sensory Discomfort | 0.001085767 | 4 | 0 | BeFree |
Hangover from alcohol | 0.001085767 | 4 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.001085767 | 4 | 3 | BeFree |
Antisocial Personality Disorder | 0.000814326 | 3 | 0 | BeFree |
Anxiety Disorders | 0.000814326 | 3 | 0 | BeFree |
Fanconi Anemia | 0.000814326 | 3 | 0 | BeFree |
Fatty Liver | 0.000814326 | 3 | 0 | BeFree |
Congestive heart failure | 0.000814326 | 3 | 0 | BeFree |
Heroin Dependence | 0.000814326 | 3 | 0 | BeFree |
Hangover from any Alcohol or Other Drugs substance | 0.000814326 | 3 | 0 | BeFree |
Melanosis coli | 0.000814326 | 3 | 0 | BeFree |
Malaise | 0.000814326 | 3 | 0 | BeFree |
Antisocial behavior | 0.000814326 | 3 | 0 | BeFree |
Multiple malignancy | 0.000814326 | 3 | 0 | BeFree |
Acute alcoholic intoxication | 0.000814326 | 3 | 0 | BeFree |
Alcohol problem | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000814326 | 3 | 0 | BeFree |
Acute pancreatitis | 0.000542884 | 2 | 0 | BeFree |
Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Mental disorders | 0.000542884 | 2 | 0 | BeFree |
Bipolar Disorder | 0.000542884 | 2 | 0 | BeFree |
Rectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cerebral Infarction | 0.000542884 | 2 | 0 | BeFree |
Presenile dementia | 0.000542884 | 2 | 0 | BeFree |
Congenital Heart Defects | 0.000542884 | 2 | 0 | BeFree |
Heart failure | 0.000542884 | 2 | 0 | BeFree |
Hyperglycemia | 0.000542884 | 2 | 1 | BeFree |
Nicotine Dependence | 0.000542884 | 2 | 6 | BeFree |
Pancytopenia | 0.000542884 | 2 | 0 | BeFree |
Psychotic Disorders | 0.000542884 | 2 | 0 | BeFree |
Conduct Disorder | 0.000542884 | 2 | 0 | BeFree |
Acute myocardial infarction | 0.000542884 | 2 | 0 | BeFree |
Bipolar II disorder | 0.000542884 | 2 | 0 | BeFree |
Alcohol or Other Drugs use | 0.000542884 | 2 | 0 | BeFree |
Impaired glucose tolerance | 0.000542884 | 2 | 2 | BeFree |
Proliferative retinopathy | 0.000542884 | 2 | 0 | BeFree |
Neuropathy | 0.000542884 | 2 | 0 | BeFree |
Dementia | 0.000542884 | 2 | 0 | BeFree |
Carotid Atherosclerosis | 0.000542884 | 2 | 0 | BeFree |
Adenoma of large intestine | 0.000542884 | 2 | 0 | BeFree |
Steatohepatitis | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Airway Obstruction | 0.000271442 | 1 | 0 | BeFree |
Alcohol Withdrawal Delirium | 0.000271442 | 1 | 0 | BeFree |
Anemia, Macrocytic | 0.000271442 | 1 | 0 | BeFree |
Autistic Disorder | 0.000271442 | 1 | 0 | BeFree |
Female Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Transitional Cell | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathy, Alcoholic | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathy, Dilated | 0.000271442 | 1 | 0 | BeFree |
Cyanosis | 0.000271442 | 1 | 0 | BeFree |
Dehydration | 0.000271442 | 1 | 0 | BeFree |
Mental Depression | 0.000271442 | 1 | 0 | BeFree |
Depressive disorder | 0.000271442 | 1 | 0 | BeFree |
Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
Diabetic Retinopathy | 0.000271442 | 1 | 0 | BeFree |
Duodenal Ulcer | 0.000271442 | 1 | 0 | BeFree |
Epilepsy | 0.000271442 | 1 | 1 | BeFree |
Gingival Diseases | 0.000271442 | 1 | 0 | BeFree |
Hyperinsulinism | 0.000271442 | 1 | 0 | BeFree |
Muscular Atrophy | 0.000271442 | 1 | 0 | BeFree |
Nausea | 0.000271442 | 1 | 0 | BeFree |
Osteoporosis | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Pseudocyst | 0.000271442 | 1 | 0 | BeFree |
Periodontal Diseases | 0.000271442 | 1 | 0 | BeFree |
polyps | 0.000271442 | 1 | 0 | BeFree |
Retinal Diseases | 0.000271442 | 1 | 0 | BeFree |
Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Tetralogy of Fallot | 0.000271442 | 1 | 0 | BeFree |
Erythema | 0.000271442 | 1 | 0 | BeFree |
Viral hepatitis | 0.000271442 | 1 | 0 | BeFree |
Photophobia | 0.000271442 | 1 | 0 | BeFree |
Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Congenital heart disease | 0.000271442 | 1 | 0 | BeFree |
Polyneuropathy | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of mouth | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pharynx | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of female breast | 0.000271442 | 1 | 0 | BeFree |
Fibrosis, Liver | 0.000271442 | 1 | 0 | BeFree |
Dyslipidemias | 0.000271442 | 1 | 1 | BeFree |
Cyanotic congenital heart disease | 0.000271442 | 1 | 0 | BeFree |
Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
Chronic liver disease | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of liver | 0.000271442 | 1 | 1 | BeFree |
Wernicke-Korsakoff Syndrome | 0.000271442 | 1 | 0 | BeFree |
Multiple lacunar infarcts | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
hazardous drinking | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of gastrointestinal tract | 0.000271442 | 1 | 0 | BeFree |
Hyperuricemia | 0.000271442 | 1 | 0 | BeFree |
Cardiac defects | 0.000271442 | 1 | 0 | BeFree |
Pharyngeal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Mitochondrial Diseases | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori infection | 0.000271442 | 1 | 0 | BeFree |
Bipolar I disorder | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathies | 0.000271442 | 1 | 0 | BeFree |
Cerebral Ischemia | 0.000271442 | 1 | 0 | BeFree |
Acute Coronary Syndrome | 0.000271442 | 1 | 0 | BeFree |
Polyp of large intestine | 0.000271442 | 1 | 0 | BeFree |
Primary Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
ST segment elevation myocardial infarction | 0.000271442 | 1 | 0 | BeFree |
CHLORPROPAMIDE-ALCOHOL FLUSHING | 0.000271442 | 1 | 0 | BeFree |
Urothelial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Chronic Total Occlusion Vessel | 0.000271442 | 1 | 0 | BeFree |
Alcohol abuse or dependence | 0.000271442 | 1 | 0 | BeFree |
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