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Kothari(Nishi),Kim(Richard),Jorissen(Rober... Acta Oncol 2016-05-19

...PIK3CA mutations. However, the number of PIK3CA-mutated CRC patients examined in these studies was modest. Our collabora...

Lo Iacono(Marco),Monica(Valentina),Righi(L... J Thorac Oncol 2016-03-08

...PIK3CA, STK11, and NF2). PIK3CA:c.1173A>G mutation, STK11:rs2075606 (T>C), or TP53:rs1042522 (Pro/Pro) was significantly...

Jimeno(A),Shirai(K),Choi(M),Laskin(J),Koch... Ann Oncol 2016-08-18

...PIK3CA mutations were observed in 17% of the cases assessed, and PTEN loss was infrequently observed.,The addition of PX...

Adi Harel(S),Bossel Ben-Moshe(N),Aylon(Y),... Cell Death Differ 2016-05-02

...PIK3CA mRNA directly. Our results imply that miR-512 and miR-373 exert cell-autonomous and non-autonomous tumor-suppress...

Arena(Sabrina),Bellosillo(Beatriz),Siraveg... Clin Cancer Res 2016-03-31

...PIK3CA genes, including two novel EGFR ectodomain mutations (R451C and K467T). Mutational profiling of cetuximab-resista...

Chandler(Ronald L),Damrauer(Jeffrey S),Raa... Nat Commun 2016-02-02

...PIK3CA. Remarkably, the mice develop highly penetrant tumours with OCCC-like histopathology, culminating in haemorrhagic...

Wu(Chunyan),Zhao(Chao),Yang(Yang),He(Yayi)... J Thorac Oncol 2016-03-21

...PIK3CA together with fusions in ALK, ROS1, and RET.,From 35 patients, a total of 72 lesions (60 were GGNs) were analyzed...

Tiseo(Marcello),Bersanelli(Melissa),Perron... Lung Cancer 2016-02-24

...PIK3CA mutation showing dramatic and persisting improvement upon erlotinib therapy, after progression during PI3K inhibi...

Pestrin(Marta),Salvianti(Francesca),Galard... Mol Oncol 2016-01-05

...PIK3CA sequencing on exons 9 and 20. Twelve subjects were wild type (wt) for the PIK3CA gene. PIK3CA status could also b...

Ling(Chao),Wang(Lin),Wang(Zheng),Xu(Luming... PLoS One 2016-01-05

...PIK3CA that had never been reported in the COSMIC or NCI-60 databases. Additionally, we confirmed 6 known somatic mutati...