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Major partial response to crizotinib, a dual MET/ALK inhibitor, in a squamous...

Schwab(Richard),Petak(Istvan),Kollar(Mihal... Lung Cancer 2014-10-01

...PIK3CA genes were wild type, ALK and ROS1 were negative for rearrangement, but c-MET was amplified by fluorescent in sit...

Frequent PIK3CA mutations in radial scars.

Wolters(Katie L),Ang(Daphne),Warrick(Andre... Diagn Mol Pathol 2014-06-26

...PIK3CA are found in 25% to 30% of invasive breast cancers; however, they have not previously been investigated in radial...

Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas.

Joseph(Christine G),Hwang(Heejung),Jiao(Yu... Genes Chromosomes Cancer 2014-03-19

...PIK3CA, SETD2, AKT1, and subclonal mutation in FBXW7. Of particular interest were mutations in H3F3A, encoding the varia...

Molecular determinants of outcome with mammalian target of rapamycin inhibiti...

Mackay(Helen J),Eisenhauer(Elizabeth A),Ka... Cancer 2014-04-08

...PIK3CA (21 patients) was the most common mutated gene. Co-mutations were seen in 8 tumors, most frequently KRAS and PIK3...

A comparative survey of functional footprints of EGFR pathway mutations in hu...

Lane(A),Segura-Cabrera(A),Komurov(K) Oncogene 2014-12-22

...PIK3CA or AKT1 mutations are, as expected, highly similar, they display markedly different, sometimes even opposite, pro...

BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110...

Liu(Ningshu),Rowley(Bruce R),Bull(Cathy O)... Mol Cancer Ther 2014-07-07

...PIK3CA mutant and/or HER2 overexpression as compared with HER2-negative and wild-type PIK3CA breast cancer cell lines. I...

PTEN expression is consistent in colorectal cancer primaries and metastases a...

Atreya(Chloe E),Sangale(Zaina),Xu(Nafei),M... Cancer Med 2014-06-09

...PIK3CA) and to overall survival (OS). PTEN expression was not significantly associated with the presence or absence of m...

Comprehensive analysis of oncogenic mutations in lung squamous cell carcinoma...

Pan(Yunjian),Wang(Rui),Ye(Ting),Li(Chengua... Chest 2014-04-23

...PIK3CA, one with BRAF, one with HER2, one each with EGFR/PIK3CA and KRAS/PIK3CA double mutations, and two with EML4-ALK ...

Association of candidate single nucleotide polymorphisms with somatic mutatio...

Wormald(Samuel),Milla(Liz),O'Connor(Liam) BMC Med Genomics 2014-06-25

...PIK3CA).,Two single nucleotide polymorphisms (SNPs) located 90 kb upstream of the TERT oncogene associated with somatic ...

Multiplex detection of DNA mutations by the fluorescence fingerprint spectrum...

Song(Jinzhao),Zhang(Jiangyan),Lv(Fengting)... Angew Chem Int Ed Engl 2014-09-12

...PIK3CA mutations originating from 30 clinical breast cancer samples could be detected.

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