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PMID: 9832527 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A genetic screen of the Drosophila X chromosome for mutations that modify Deformed function.

Genetics ·Vol. 150 ·No. 4 ·1998-12-00 ·Pages 1497-511

Florence B, McGinnis W

Abstract

We have screened the Drosophila X chromosome for genes whose dosage affects the function of the homeotic gene Deformed. One of these genes, extradenticle, encodes a homeodomain transcription factor that heterodimerizes with Deformed and other homeotic Hox proteins. Mutations in the nejire gene, which encodes a transcriptional adaptor protein belonging to the CBP/p300 family, also interact with Deformed. The other previously characterized gene identified as a Deformed interactor is Notch, which encodes a transmembrane receptor. These three genes underscore the importance of transcriptional regulation and cell-cell signaling in Hox function. Four novel genes were also identified in the screen. One of these, rancor, is required for appropriate embryonic expression of Deformed and another homeotic gene, labial. Both Notch and nejire affect the function of another Hox gene, Ultrabithorax, indicating they may be required for homeotic activity in general.

MeSH Terms
Animals Drosophila/genetics Drosophila Proteins Female Gene Expression Regulation, Developmental Genes, Insect Genetic Testing Homeodomain Proteins/genetics,physiology Male Mutation Phenotype X Chromosome
Chemicals
Dfd protein, Drosophila Drosophila Proteins Homeodomain Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Florence B
Department of Biology, University of California, San Diego, California 92093, USA.
McGinnis W
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/150.4.1497
Published
1998-12-00
Pages
1497-511
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1460420
Subset
IM
Grants
NIGMS NIH HHS · GM16535-04 · United States
NICHD NIH HHS · HD28315 · United States
External Links
PubMed source DOI: 10.1093/genetics/150.4.1497 PMC Full Text View journal details
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