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PMID: 7498774 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A screen for modifiers of Deformed function in Drosophila.

Genetics ·Vol. 140 ·No. 4 ·1995-08-00 ·Pages 1339-52

Harding KW, Gellon G, McGinnis N, McGinnis W

Abstract

Proteins produced by the homeotic genes of the Hox family assign different identifies to cells on the anterior/posterior axis. Relatively little is known about the signalling pathways that modulate their activities or the factors with which they interact to assign specific segmental identifies. To identify genes that might encode such functions, we performed a screen for second site mutations that reduce the viability of animals carrying hypomorphic mutant alleles of the Drosophila homeotic locus, Deformed. Genes mapping to six complementation groups on the third chromosome were isolated as modifiers of Deformed function. Products of two of these genes, sallimus and moira, have been previously proposed as homeotic activators since they suppress the dominant adult phenotype of Polycomb mutants. Mutations in hedgehog, which encodes secreted signalling proteins, were also isolated as Deformed loss-of-function enhancers. Hedgehog mutant alleles also suppress the Polycomb phenotype. Mutations were also isolated in a few genes that interact with Deformed but not with Polycomb, indicating that the screen identified genes that are not general homeotic activators. Two of these genes, cap 'n' collar and defaced, have defects in embryonic head development that are similar to defects seen in loss of function Deformed mutants.

MeSH Terms
Animals Chromosome Mapping Crosses, Genetic DNA-Binding Proteins/genetics,physiology Drosophila Proteins Drosophila melanogaster/embryology,genetics Female Gene Expression Regulation, Developmental Genes, Dominant Genes, Lethal Genetic Complementation Test Head/embryology Hedgehog Proteins Homeodomain Proteins/genetics,physiology Male Morphogenesis/genetics Phenotype Polycomb Repressive Complex 1 Proteins/genetics,physiology Suppression, Genetic Transcription Factors
Chemicals
DNA-Binding Proteins Dfd protein, Drosophila Drosophila Proteins Hedgehog Proteins Homeodomain Proteins Pc protein, Drosophila Proteins Transcription Factors Trl protein, Drosophila hh protein, Drosophila Polycomb Repressive Complex 1
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Harding K W
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven Connecticut 06520-8114, USA.
Gellon G
McGinnis N
McGinnis W
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
Published
1995-08-00
Pages
1339-52
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1206698
Subset
IM
Grants
NIGMS NIH HHS · GM-07499 · United States
NICHD NIH HHS · HD-30368 · United States
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