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PMID: 8514133 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus.

Genetics ·Vol. 134 ·No. 1 ·1993-05-00 ·Pages 243-9

Dorer DR, Cadden MA, Gordesky-Gold B, Harries G, Christensen AC

Abstract

One of the most extreme examples of gene dosage sensitivity is the Triplo-lethal locus (Tpl) on the third chromosome of Drosophila melanogaster, which is lethal when present in either one or three copies. Increased dosage of an unlinked locus, Isis, suppresses the triplo-lethal phenotype of Tpl, but not the haplo-lethal phenotype. We have mapped Isis to the X chromosome region 7E3-8A5, and shown that the suppression is a gene dosage effect. Altered dosage of Isis in the presence of two copies of Tpl has no obvious effects. By examining the interactions between Isis dosage and Tpl we suggest that Isis does not directly repress Tpl expression, but acts downstream on the triplo-lethal phenotype of Tpl.

Related Genes
Tpl
MeSH Terms
Animals Chromosome Mapping Drosophila melanogaster/genetics Female Genes, Lethal Genetic Linkage Male Multigene Family Mutation Phenotype Suppression, Genetic Translocation, Genetic Trisomy X Chromosome Y Chromosome
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Dorer D R
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5541.
Cadden M A
Gordesky-Gold B
Harries G
Christensen A C
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/134.1.243
Published
1993-05-00
Pages
243-9
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1205427
Subset
IM
Grants
NIGMS NIH HHS · R29-GM38483 · United States
External Links
PubMed source DOI: 10.1093/genetics/134.1.243 PMC Full Text View journal details
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