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PMID: 965004 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Rapid detection of glyoxalase I (GLO) on cellulose acetate gel and the distribution of GLO variants in a Dutch population.

Human genetics ·Vol. 34 ·No. 1 ·1976-09-10 ·Pages 53-6

Meera Khan P, Doppert BA

Abstract

A rapid electrophoretic procedure is described for detecting the human red cell glyoxalase I variants (GLO 1, GLO 2-1, and GLO 2) on cellulose acetate gel (cellogel) on which the sites of enzymed activity are visualized as purple bands against white background. The frequency of GLO1 gene in a Dutch population living in and around Leiden was found to be 0.4544.

MeSH Terms
Electrophoresis, Cellulose Acetate/methods Gene Frequency Genetic Variation Humans Lactoylglutathione Lyase/blood Lyases/blood Netherlands Phenotype
Chemicals
Lyases Lactoylglutathione Lyase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Meera Khan P
Doppert B A
References (7)
7 references, click to expand
  1. Red cell glyoxalase i (E.C.: 4.4.1.5): formal genetics and linkage relations.
    Humangenetik. 1975 Jul 23;28(3):249-51 PMID: 1150284
  2. Keto-aldehydes and cell division.
    Science. 1967 Feb 3;155(3762):539-41 PMID: 5333756
  3. Rapid detection of 6-phosphogluconate dehydrogenase variants by electrophoresis on cellulose acetate gel.
    Biochem Genet. 1968 Nov;2(3):231-5 PMID: 5715187
  4. Enzyme electrophoresis on cellulose acetate gel: zymogram patterns in mgh-mouse and man--Chinese hamster somatic cell hybrids.
    Arch Biochem Biophys. 1971 Aug;145(2):470-83 PMID: 4331030
  5. Population genetics of red cell glyoxalase I (E.C.:4.4.1.5): Gene frequencies in southwestern Germany.
    Humangenetik. 1975 Jun 19;28(2):175-6 PMID: 1150273
  6. Linkage relationships of the loci of the major histocompatibility complex in families with a recombination in the HLA region.
    J Immunogenet. 1976 Jun;3(3):171-83 PMID: 965767
  7. Polymorphism of red cell glyoxalase I (EI: 4.4.1.5); a new genetic marker in man. Investigation of 169 mother-child combinations.
    Humangenetik. 1975;27(2):141-3 PMID: 1150236
Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00284434
Published
1976-09-10
Pages
53-6
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00284434 View journal details
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