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Identification of a novel p53 functional domain that is necessary for efficient growth suppression.
Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15335-40
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New insights into p53 function from structural studies.
Oncogene. 1996 Apr 4;12(7):1379-85
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Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion.
Oncogene. 1996 Apr 18;12(8):1755-65
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Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.
EMBO J. 1996 Feb 15;15(4):827-38
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Biological and clinical importance of the p53 tumor suppressor gene.
Clin Chem. 1996 Jun;42(6 Pt 1):858-68
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Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
EMBO J. 1996 Apr 1;15(7):1596-606
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The cellular effects of E2F overexpression.
Curr Top Microbiol Immunol. 1996;208:79-93
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Adenovirus-mediated transfer of HPV 16 E6/E7 antisense RNA to human cervical cancer cells.
Gynecol Oncol. 1996 Nov;63(2):219-27
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p53, the cellular gatekeeper for growth and division.
Cell. 1997 Feb 7;88(3):323-31
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Neoangiogenesis and p53 protein in lung cancer: their prognostic role and their relation with vascular endothelial growth factor (VEGF) expression.
Br J Cancer. 1997;75(9):1295-301
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Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes.
J Exp Med. 1997 Mar 3;185(5):833-41
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Interaction between ATM protein and c-Abl in response to DNA damage.
Nature. 1997 May 29;387(6632):520-3
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Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.
Oncogene. 1997 Apr 17;14(15):1859-68
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Essential role for p53-mediated transcription in E1A-induced apoptosis.
Genes Dev. 1995 Sep 1;9(17):2184-92
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Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.
Science. 1997 Feb 14;275(5302):967-9
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Life, death, and the pursuit of apoptosis.
Genes Dev. 1996 Jan 1;10(1):1-15
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p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells.
Oncogene. 1997 Feb 27;14(8):929-35
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Transferrin-liposome-mediated p53 sensitization of squamous cell carcinoma of the head and neck to radiation in vitro.
Hum Gene Ther. 1997 Mar 1;8(4):467-75
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Wilms' tumor 1-KTS isoforms induce p53-independent apoptosis that can be partially rescued by expression of the epidermal growth factor receptor or the insulin receptor.
Cancer Res. 1997 Apr 1;57(7):1353-63
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Antisense technology and prospects for therapy of viral infections and cancer.
Mol Med Today. 1997 Jan;3(1):31-8
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A novel p53 germline alteration identified in a late onset breast cancer kindred.
Oncogene. 1996 Jul 18;13(2):407-11
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Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53.
Cancer Res. 1995 Aug 15;55(16):3490-4
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Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis.
Nat Med. 1996 Jan;2(1):72-9
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Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients.
Nat Med. 1996 Jul;2(7):811-4
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The growth-inhibitory function of p53 is separable from transactivation, apoptosis and suppression of transformation by E1a and Ras.
Oncogene. 1996 Sep 5;13(5):995-1007
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Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function.
Mol Cell Biol. 1996 Sep;16(9):4952-60
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p53 in growth control and neoplasia.
Biochim Biophys Acta. 1996 Jun 7;1287(2-3):77-102
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The humoral response to the tumor-suppressor gene-product p53 in human cancer: implications for diagnosis and therapy.
Immunol Today. 1996 Aug;17(8):354-6
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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53.
Nature. 1995 Nov 9;378(6553):203-6
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Expression of p53, glutathione S-transferase-pi, and Bcl-2 proteins and benefit from adjuvant radiotherapy in breast cancer.
J Natl Cancer Inst. 1997 May 7;89(9):639-45
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UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.
J Natl Cancer Inst. 1996 Jul 17;88(14):956-65
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MDM2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis.
Oncogene. 1995 May 18;10(10):2001-6
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p53--integrating the complexity.
J Pathol. 1996 Sep;180(1):1-5
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Two functional assays employed to detect an unusual mutation in the oligomerisation domain of p53 in a Li-Fraumeni like family.
Oncogene. 1997 Apr 17;14(15):1869-74
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p53 and ATM: cell cycle, cell death, and cancer.
Adv Cancer Res. 1997;71:1-25
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p53 as a target for anti-cancer immunotherapy.
Mol Med Today. 1997 Apr;3(4):160-7
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The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis.
Genes Dev. 1995 Sep 1;9(17):2143-56
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Bax suppresses tumorigenesis and stimulates apoptosis in vivo.
Nature. 1997 Feb 13;385(6617):637-40
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A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis.
EMBO J. 1997 Jul 16;16(14):4384-92
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mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein.
Mol Cell Biol. 1996 May;16(5):2445-52
PMID: 8628312
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Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis.
EMBO J. 1996 Jul 15;15(14):3693-701
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Activation of CPP32 and Mch3 alpha in wild-type p53-induced apoptosis.
Biochem J. 1997 Feb 15;322 ( Pt 1):19-23
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Nuclear accumulation of mutant p53 protein: a possible predictor of failure of intravesical therapy in bladder cancer.
Br J Urol. 1997 Mar;79(3):373-7
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Gene delivery into malignant cells in vivo by a conjugated adenovirus/DNA complex.
Cancer Gene Ther. 1997 May-Jun;4(3):183-90
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Gene therapy for lung cancer: enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer.
J Thorac Cardiovasc Surg. 1996 Nov;112(5):1372-6; discussion 1376-7
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Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death.
Nat Med. 1997 Mar;3(3):313-9
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p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.
Genes Dev. 1996 Oct 1;10(19):2438-51
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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6.
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Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase.
Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1437-40
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The spectrum of mutations at the p53 locus. Evidence for tissue-specific mutagenesis, selection of mutant alleles, and a "gain of function" phenotype.
Ann N Y Acad Sci. 1995 Sep 30;768:111-28
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Tumor suppressors: a developing role for p53?
Curr Biol. 1997 Mar 1;7(3):R144-7
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Clinical implications of the p53 gene.
Annu Rev Med. 1996;47:285-301
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T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53.
EMBO J. 1996 Mar 15;15(6):1221-30
PMID: 8635454
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The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal.
Mol Cell Biol. 1997 Mar;17(3):1084-92
PMID: 9032235
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A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis.
Mol Cell Biol. 1996 Sep;16(9):4961-71
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Identification of novel mdm2 binding peptides by phage display.
Oncogene. 1996 Nov 21;13(10):2141-7
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Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression.
Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2587-92
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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.
Genes Dev. 1994 May 15;8(10):1235-46
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Gene therapy for cancer: what have we done and where are we going?
J Natl Cancer Inst. 1997 Jan 1;89(1):21-39
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Role of p53 in drug resistance in ovarian cancer.
Lancet. 1997 Mar 15;349(9054):744-5
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Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain.
Nat Med. 1997 Jun;3(6):632-8
PMID: 9176489
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p53 as a target for cancer vaccines: recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge.
Proc Natl Acad Sci U S A. 1996 May 14;93(10):4781-6
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p53-mediated apoptosis in HeLa cells can be overcome by excess pRB.
Oncogene. 1995 Apr 20;10(8):1563-71
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p53; from inductive signal to cellular effect.
Curr Opin Genet Dev. 1997 Feb;7(1):46-51
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The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53?
Bioessays. 1993 Oct;15(10):689-90
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Regulation of apoptosis by viral gene products.
J Virol. 1997 Mar;71(3):1739-46
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Therapeutic targeting of the p53 tumor suppressor gene.
Curr Opin Biotechnol. 1996 Dec;7(6):592-600
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Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression.
Mol Cell Biol. 1995 Jun;15(6):3032-40
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Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells.
Nat Med. 1996 May;2(5):574-7
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Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccines.
J Exp Med. 1996 Apr 1;183(4):1357-65
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Recruitment of p300/CBP in p53-dependent signal pathways.
Cell. 1997 Jun 27;89(7):1175-84
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p53 in signaling checkpoint arrest or apoptosis.
Curr Opin Genet Dev. 1996 Feb;6(1):12-8
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Identification of a p53-dependent negative response element in the bcl-2 gene.
Cancer Res. 1994 Jun 15;54(12):3131-5
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p53-mediated apoptosis: mechanisms and regulation.
Behring Inst Mitt. 1996 Oct;(97):32-59
PMID: 8950466
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The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M.
Mol Cell Biol. 1996 Jul;16(7):3884-92
PMID: 8668206
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The proto-oncogene Bcl-2 and its role in regulating apoptosis.
Nat Med. 1997 Jun;3(6):614-20
PMID: 9176486
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Immunohistochemical detection of bcl-2 and p53 proteins and apoptosis in soft tissue sarcoma: their correlations with prognosis.
Oncology. 1997 May-Jun;54(3):238-44
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Failure to dephosphorylate retinoblastoma protein in drug-resistant cells.
Cancer Res. 1995 Nov 15;55(22):5222-5
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Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.
Cancer Res. 1994 Feb 1;54(3):794-9
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Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer.
Nat Med. 1996 Sep;2(9):985-91
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The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.
Genes Dev. 1996 May 15;10(10):1219-32
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p53: puzzle and paradigm.
Genes Dev. 1996 May 1;10(9):1054-72
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Role for c-Abl tyrosine kinase in growth arrest response to DNA damage.
Nature. 1996 Jul 18;382(6588):272-4
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Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies.
J Natl Cancer Inst. 1996 Oct 16;88(20):1442-55
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The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products.
EMBO J. 1996 Apr 1;15(7):1583-95
PMID: 8612582
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Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest.
Blood. 1995 May 15;85(10):2691-8
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DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies.
Oncogene. 1996 Nov 7;13(9):1971-81
PMID: 8934544
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Wild-type p53 negatively regulates the expression of a microtubule-associated protein.
Genes Dev. 1996 Dec 1;10(23):2971-80
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P53 gene alterations in human tumors: perspectives for cancer control.
Recent Results Cancer Res. 1997;143:369-89
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Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells.
Mol Cell Biol. 1993 Jan;13(1):711-9
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The mdm-2 gene is induced in response to UV light in a p53-dependent manner.
Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11623-7
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Small peptides activate the latent sequence-specific DNA binding function of p53.
Cell. 1995 Oct 20;83(2):237-45
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ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents.
Nat Med. 1997 Jun;3(6):639-45
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Induction of apoptosis in HeLa cells by trans-activation-deficient p53.
Genes Dev. 1995 Sep 1;9(17):2170-83
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Complex formation between the lymphotropic papovavirus large tumor antigen and the tumor suppressor protein p53.
J Virol. 1991 Oct;65(10):5417-24
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Gas1-induced growth suppression requires a transactivation-independent p53 function.
Mol Cell Biol. 1995 Dec;15(12):7152-60
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Mdm2 promotes the rapid degradation of p53.
Nature. 1997 May 15;387(6630):296-9
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Viruses and apoptosis.
Curr Opin Genet Dev. 1995 Feb;5(1):105-11
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Cancer cell cycles.
Science. 1996 Dec 6;274(5293):1672-7
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A simple p53 functional assay for screening cell lines, blood, and tumors.
Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3963-7
PMID: 7732013
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How phosphorylation regulates the activity of p53.
J Mol Biol. 1996 Oct 25;263(2):103-13
PMID: 8913292
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The role of p53 as a transcription factor in the induction of apoptosis.
Behring Inst Mitt. 1996 Oct;(97):60-71
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A p53-dependent mouse spindle checkpoint.
Science. 1995 Mar 3;267(5202):1353-6
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