Therapeutic targeting of the p53 tumor suppressor gene.

Current opinion in biotechnology ·Vol. 7 ·No. 6 ·1996-12-00 ·Pages 592-600

Beaudry GA, Bertelsen AH, Sherman MI

Abstract

The p53 tumor suppressor gene is a logical target for cancer therapy. Several therapeutic strategies can be envisioned based upon recent advances concerning structure and function of the p53 protein, its interaction with cellular and viral proteins and its roles in repairing DNA, regulating cell division and promoting apoptosis.

MeSH Terms

Antineoplastic Agents/pharmacology,therapeutic use Gene Expression Regulation, Neoplastic Genes, p53/drug effects Genetic Therapy Genetic Vectors/therapeutic use Humans Mutation Neoplasms/genetics,immunology,therapy Tumor Suppressor Protein p53/chemistry,physiology

Chemicals

Antineoplastic Agents Tumor Suppressor Protein p53

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Beaudry G A

PharmaGenics Inc, 4 Pearl Court, Allendale, NJ 07401, USA. beaudry@pharmag.com

Bertelsen A H

Sherman M I

Article Info

Journal

Current opinion in biotechnology

Abbr.

Curr Opin Biotechnol

ISSN

0958-1669

DOI

10.1016/s0958-1669(96)80069-3

beaudry@pharmag.com

Published

1996-12-00

Pages

592-600

Language

English

Region

England

NLM ID

9100492

Subset

External Links

PubMed source DOI: 10.1016/s0958-1669(96)80069-3 View journal details

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Therapeutic targeting of the p53 tumor suppressor gene.

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