Home LiteratureArticle Details
PMID: 9400933 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer.

British journal of cancer ·Vol. 76 ·No. 11 ·1997-00-00 ·Pages 1398-404

Velikova G, Banks RE, Gearing A, Hemingway I, Forbes MA, Preston SR, Jones M, Wyatt J, Miller K, Ward U, Al-Maskatti J, Singh SM, Ambrose NS, Primrose JN, Selby PJ

Abstract

The concentrations of the soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were investigated in 45 patients with gastric cancer before treatment and their correlation with clinical, histological and routine laboratory parameters was examined. Data were collected on tumour stage at presentation, presence and sites of metastatic disease, tumour pathology, survival and results of routine laboratory tests. Serum concentrations of ICAM-1 and VCAM-1 were significantly elevated in the patients with gastric cancer in comparison with the group of healthy subjects (P < 0.00001 and P < 0.0001 respectively). Increased serum concentrations of VCAM-1 were associated with locally advanced and metastatic disease whereas ICAM-1 was significantly elevated both in local and in advanced/metastatic disease. Soluble E-cadherin and E-selectin concentrations did not show any significant elevation in gastric cancer patients. Concentrations of soluble adhesion molecules showed significant correlation with each other (except E-selectin and VCAM-1) and with alkaline phosphatase. Soluble ICAM-1 and VCAM-1 were significantly associated with an elevated total white cell count. Patients with elevated VCAM-1 had significantly poorer survival in comparison with patients with normal serum levels (P = 0.0361).

MeSH Terms
Adult Aged Aged, 80 and over Cadherins/blood E-Selectin/blood Female Humans Intercellular Adhesion Molecule-1/blood Male Middle Aged Solubility Stomach Neoplasms/blood Vascular Cell Adhesion Molecule-1/blood
Chemicals
Cadherins E-Selectin Vascular Cell Adhesion Molecule-1 Intercellular Adhesion Molecule-1
Authors & Affiliations
15 authors, click to expand affiliations / ORCID
Velikova G
ICRF Cancer Medicine Research Unit, St James's University Hospital, Leeds, UK.
Banks R E
Gearing A
Hemingway I
Forbes M A
Preston S R
Jones M
Wyatt J
Miller K
Ward U
Al-Maskatti J
Singh S M
Ambrose N S
Primrose J N
Selby P J
References (49)
49 references, click to expand
  1. Clinicopathological staging of gastric cancer.
    Br J Surg. 1984 Sep;71(9):677-80 PMID: 6206907
  2. Elevated serum E-selectin in patients with liver metastases of colorectal cancer.
    Eur J Cancer. 1996 Jun;32A(7):1215-8 PMID: 8758256
  3. The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus.
    Cell. 1990 Apr 20;61(2):243-54 PMID: 1970514
  4. Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression.
    Cancer Res. 1990 Oct 15;50(20):6757-64 PMID: 2208139
  5. Cell adhesion molecules. Structure, function, and implication in a variety of cutaneous and other pathologic conditions.
    Int J Dermatol. 1991 Mar;30(3):153-60 PMID: 2037399
  6. Expression of E-cadherin in human gastric carcinomas.
    Gastroenterol Jpn. 1991 Apr;26(2):231 PMID: 2040405
  7. Detection of circulating intercellular adhesion molecule-1 antigen in malignant diseases.
    Clin Exp Immunol. 1991 Jul;85(1):3-8 PMID: 1712683
  8. Serum levels of circulating intercellular adhesion molecule 1 in human malignant melanoma.
    Cancer Res. 1991 Sep 15;51(18):5003-5 PMID: 1680025
  9. Soluble intercellular adhesion molecule 1 is released by human melanoma cells and is associated with tumor growth in nude mice.
    Cancer Res. 1992 May 1;52(9):2628-30 PMID: 1348968
  10. Detection of circulating intercellular adhesion molecule-1 in chronic liver diseases.
    Hepatology. 1992 Sep;16(3):810-4 PMID: 1354635
  11. Circulating intercellular adhesion molecule 1 as a marker of disease progression in cutaneous melanoma.
    N Engl J Med. 1992 Sep 24;327(13):959 PMID: 1355268
  12. Expression of intercellular adhesion molecule 1 (ICAM-1) during the development of invasion and/or metastasis of gastric carcinoma.
    J Cancer Res Clin Oncol. 1992;118(8):609-14 PMID: 1355484
  13. Role of integrins and other cell adhesion molecules in tumor progression and metastasis.
    Lab Invest. 1993 Jan;68(1):4-17 PMID: 8423675
  14. Analysis of expression and soluble form of intercellular adhesion molecule-1 in malignant melanoma.
    J Dermatol. 1992 Nov;19(11):836-40 PMID: 1284075
  15. E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration.
    Cancer Res. 1993 Apr 1;53(7):1690-5 PMID: 8453643
  16. Dimethyl sulfoxide (DMSO) increases expression of sialyl Lewis x antigen and enhances adhesion of human gastric carcinoma (NUGC4) cells to activated endothelial cells.
    Int J Cancer. 1993 May 8;54(2):296-301 PMID: 7683631
  17. Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies.
    Br J Cancer. 1993 Jul;68(1):122-4 PMID: 7686390
  18. Specificity of anti-carcinoembryonic antigen monoclonal antibodies and their effects on CEA-mediated adhesion.
    Cancer Res. 1993 Aug 15;53(16):3817-22 PMID: 7687926
  19. Expression of intercellular adhesion molecule-1 in hepatocellular carcinoma.
    J Surg Oncol. 1993 Aug;53(4):239-42 PMID: 8101890
  20. Homophilic adhesion between Ig superfamily carcinoembryonic antigen molecules involves double reciprocal bonds.
    J Cell Biol. 1993 Aug;122(4):951-60 PMID: 8349740
  21. Serum levels of circulating ICAM-1 are increased in Hodgkin's disease.
    Leukemia. 1993 Aug;7(8):1245-9 PMID: 8102418
  22. Soluble forms of vascular adhesion molecules, E-selectin, ICAM-1, and VCAM-1: pathological significance.
    Ann N Y Acad Sci. 1992 Dec 4;667:324-31 PMID: 1285023
  23. Adhesion molecules in tumor metastasis.
    Semin Cancer Biol. 1993 Aug;4(4):219-29 PMID: 8400144
  24. Soluble intercellular adhesion molecule 1 (sICAM-1) and malignant melanoma.
    Cancer Lett. 1993 Aug 31;72(3):191-4 PMID: 8104685
  25. Clinical relevance of ICAM-1 expression in primary lesions and serum of patients with malignant melanoma.
    Cancer Res. 1993 Oct 15;53(20):4927-32 PMID: 8104688
  26. The structural and functional analysis of cadherin calcium-dependent cell adhesion molecules.
    Curr Opin Cell Biol. 1993 Oct;5(5):797-805 PMID: 8240823
  27. Cadherins in cancer: implications for invasion and metastasis.
    Curr Opin Cell Biol. 1993 Oct;5(5):806-11 PMID: 8240824
  28. Detection of circulating intercellular adhesion molecule-1 in hepatocellular carcinoma.
    Int J Cancer. 1993 Nov 11;55(5):775-9 PMID: 7503959
  29. Circulating intercellular adhesion molecule-1 (ICAM-1) in autoimmune liver disease and evidence for the production of ICAM-1 by cytokine-stimulated human hepatocytes.
    Clin Exp Immunol. 1994 Jan;95(1):83-90 PMID: 7904546
  30. Endothelial activation and circulating vascular adhesion molecules in alcoholic liver disease.
    Hepatology. 1994 Mar;19(3):588-94 PMID: 7509770
  31. Soluble interleukin-2 receptor, soluble CD8 and soluble intercellular adhesion molecule-1 levels in hematologic malignancies.
    Leuk Lymphoma. 1994 Jan;12(3-4):241-51 PMID: 7909467
  32. Selectins.
    Curr Opin Immunol. 1994 Feb;6(1):75-84 PMID: 7513527
  33. Tumor metastasis formation: cell-surface proteins confer metastasis-promoting or -suppressing properties.
    Biochim Biophys Acta. 1994 May 27;1198(1):1-10 PMID: 8199192
  34. Adhesion molecules: novel molecular tools in tumor pathology.
    Hum Pathol. 1994 Sep;25(9):849-56 PMID: 8088758
  35. Leukocyte-endothelial adhesion molecules.
    Blood. 1994 Oct 1;84(7):2068-101 PMID: 7522621
  36. Circulating intercellular adhesion molecule-1 (cICAM-1) concentration in liver disease. Relationship with cholestasis and functioning hepatic mass.
    Am J Clin Pathol. 1994 Nov;102(5):600-4 PMID: 7942624
  37. Prediction of serum markers of fibrosis by levels of circulating intercellular adhesion molecule-1 in acute and chronic liver disease.
    Clin Biochem. 1994 Oct;27(5):407-12 PMID: 7867219
  38. Soluble forms of the adhesion molecule E-cadherin in urine.
    J Clin Pathol. 1995 Feb;48(2):179-80 PMID: 7745120
  39. Variations in the expression of cell-adhesion molecules on liver-associated lymphocytes and peripheral-blood lymphocytes in patients with and without liver metastasis.
    Int J Cancer. 1995 May 16;61(4):475-9 PMID: 7759152
  40. Soluble E-cadherin: a novel cutaneous disease marker.
    Br J Dermatol. 1995 May;132(5):745-9 PMID: 7772479
  41. Prostate-specific antigen messenger RNA is expressed in non-prostate cells: implications for detection of micrometastases.
    Cancer Res. 1995 Jun 15;55(12):2640-4 PMID: 7540108
  42. Cell adhesion molecule expression by vascular endothelial cells as an immune/inflammatory reaction in human colon carcinoma.
    Jpn J Cancer Res. 1995 Jun;86(6):585-93 PMID: 7542647
  43. Serum concentration of intercellular adhesion molecule-1 in patients with hepatocellular carcinoma is a marker of the disease progression and prognosis.
    Hepatology. 1995 Aug;22(2):525-31 PMID: 7543436
  44. Serum levels of interleukin-1, interleukin-6 and tumour necrosis factor-alpha in patients with gastric carcinoma.
    Cancer Lett. 1995 Aug 16;95(1-2):207-12 PMID: 7656232
  45. Expression on leukemic cells and serum circulating levels of intercellular adhesion molecule-1 (ICAM-1) in B-cell chronic lymphocytic leukemia: implications for prognosis.
    Leuk Res. 1995 Aug;19(8):573-80 PMID: 7658704
  46. Soluble E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in primary biliary cirrhosis.
    J Hepatol. 1995 Apr;22(4):416-22 PMID: 7545197
  47. Clinicopathologic evaluation of immunohistochemical E-cadherin expression in human gastric carcinomas.
    Cancer. 1995 Dec 1;76(11):2193-201 PMID: 8635021
  48. Serum interleukin-6 levels reflect disease status of gastric cancer.
    Am J Gastroenterol. 1996 Jul;91(7):1417-22 PMID: 8678006
  49. Carcinoembryonic antigen as a selective enhancer of colorectal cancer metastasis.
    J Natl Cancer Inst. 1990 Mar 7;82(5):380-5 PMID: 2304087
Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1997.569
Published
1997-00-00
Pages
1398-404
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2228185
Subset
IM
External Links
PubMed source DOI: 10.1038/bjc.1997.569 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2