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PMID: 7686390 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies.

British journal of cancer ·Vol. 68 ·No. 1 ·1993-07-00 ·Pages 122-4

Banks RE, Gearing AJ, Hemingway IK, Norfolk DR, Perren TJ, Selby PJ

Abstract

Cellular adhesion molecules have been implicated in tumour progression and metastasis. This study examines for the first time the serum concentrations of circulating VCAM-1 and E-selectin in a consecutive series of 110 cancer patients seen in a general medical oncology clinic, and confirms and extends previous studies reporting measurement of circulating ICAM-1. Soluble ICAM-1 and VCAM-1 levels were significantly higher in all the patient groups compared with the controls whereas soluble E-selectin was significantly higher in the ovarian, breast and GI cancer groups and lower in the myeloma group. The significance of these results together with the possible sources and stimuli for release of these adhesion molecules are discussed.

MeSH Terms
Adult Antigens, CD/blood Biomarkers, Tumor/blood Breast Neoplasms/blood Cell Adhesion Molecules/blood E-Selectin Female Follow-Up Studies Gastrointestinal Neoplasms/blood Humans Intercellular Adhesion Molecule-1 Kidney Neoplasms/blood Lymphoma/blood Middle Aged Multiple Myeloma/blood Neoplasms/blood Ovarian Neoplasms/blood Reference Values Urinary Bladder Neoplasms/blood Vascular Cell Adhesion Molecule-1
Chemicals
Antigens, CD Biomarkers, Tumor Cell Adhesion Molecules E-Selectin Vascular Cell Adhesion Molecule-1 Intercellular Adhesion Molecule-1
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Banks R E
Yorkshire Cancer Research Campaign Institute for Cancer Studies, Department of Clinical Medicine, University of Leeds, St. James's University Hospital, UK.
Gearing A J
Hemingway I K
Norfolk D R
Perren T J
Selby P J
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20 references, click to expand
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1993.298
Published
1993-07-00
Pages
122-4
Language
English
Region
England
NLM ID
0370635
PMCID
PMC1968321
Subset
IM
External Links
PubMed source DOI: 10.1038/bjc.1993.298 PMC Full Text View journal details
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