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PMID: 1355484 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Expression of intercellular adhesion molecule 1 (ICAM-1) during the development of invasion and/or metastasis of gastric carcinoma.

Journal of cancer research and clinical oncology ·Vol. 118 ·No. 8 ·1992-00-00 ·Pages 609-14

Koyama S, Ebihara T, Fukao K

Abstract

In this study, using two-color flow-cytometric analysis, we examined the expression of histocompatibility locus antigens (HLA) classes I and II, and intercellular adhesion molecule 1 (ICAM-1) in 10 cases of normal gastric mucosa, 13 cases of primary carcinoma on the stomach, 16 cases of metastatic carcinoma from malignant ascites in patients with gastric carcinoma and 14 samples of their cultured carcinoma cells. Compared with normal gastric mucosa, HLA class I were highly expressed in a considerable number of tumor cells in each experimental group. The expression of HLA class II tended to reduce in the order of normal gastric mucosa, primary gastric carcinoma and peritoneal-effusion-associated carcinoma. Altogether, 85.7% of cases of cultured tumor cells showed abrogation and loss of HLA class II. The ICAM-1 molecule was not detected on normal gastric epithelial cells. In few cases, carcinoma cells from large volumes of tumor located in the stomach showed detectable amounts of ICAM-1. On the other hand, all of the metastatic carcinoma cells from peritoneal effusions showed a high level of expression of the ICAM-1 molecule. The expression of ICAM-1 on adenocarcinoma cells was maintained and/or augmented by in vitro cultivation with tumor-infiltrating lymphocytes (TIL). Furthermore, two-color fluorescence-activated cell sorting analysis of TIL revealed that significant correlation was observed between the expression of ICAM-1 and the degree of TIL, composed mainly of CD3+ T cells including CD8+CD11b-, CD8+CD28+, CD8+S6F1+ and CD4+Leu8+, and CD57+CD16- and CD57+CD16+ NK cells, and HLA-DR+LeuM3+ macrophages.

MeSH Terms
Adenocarcinoma/immunology,secondary Adult Aged Antigens, CD/analysis Antigens, Neoplasm/analysis Ascitic Fluid/immunology Cell Adhesion Molecules/analysis,immunology Flow Cytometry Gastric Mucosa/immunology Histocompatibility Antigens Class I/analysis Histocompatibility Antigens Class II/analysis Humans Intercellular Adhesion Molecule-1 Middle Aged Neoplasm Invasiveness/immunology Neoplasm Metastasis/immunology Stomach Neoplasms/immunology,secondary
Chemicals
Antigens, CD Antigens, Neoplasm Cell Adhesion Molecules Histocompatibility Antigens Class I Histocompatibility Antigens Class II Intercellular Adhesion Molecule-1
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Koyama S
Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.
Ebihara T
Fukao K
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42 references, click to expand
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Article Info
Journal
Journal of cancer research and clinical oncology
Abbr.
J Cancer Res Clin Oncol
ISSN
0171-5216
DOI
10.1007/BF01211806
Published
1992-00-00
Pages
609-14
Language
English
Region
Germany
NLM ID
7902060
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01211806 View journal details
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