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PMID: 9238010 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 94 ·No. 16 ·1997-08-05 ·Pages 8527-32

Thompson CC, Bottcher MC

Abstract

Thyroid hormone is a critical mediator of central nervous system (CNS) development, acting through nuclear receptors to modulate the expression of specific genes. Transcription of the rat hairless (hr) gene is highly up-regulated by thyroid hormone in the developing CNS; we show here that hr is directly induced by thyroid hormone. By identifying proteins that interact with the hr gene product (Hr), we find that Hr interacts directly and specifically with thyroid hormone receptor (TR)-the same protein that regulates its expression. Unlike previously described receptor-interacting factors, Hr associates with TR and not with retinoic acid receptors (RAR, RXR). Hr can act as a transcriptional repressor, suggesting that its interaction with TR is part of a novel autoregulatory mechanism.

MeSH Terms
Animals Gene Expression Regulation/drug effects Proteins/genetics,metabolism Rats Receptors, Thyroid Hormone/genetics,metabolism Thyroid Hormones/genetics,metabolism,pharmacology Transcription Factors Transfection
Chemicals
Proteins Receptors, Thyroid Hormone Thyroid Hormones Transcription Factors hr protein, rat
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Thompson C C
Department of Neuroscience, Johns Hopkins University School of Medicine, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA. ccthomps@welchlink.welch.jhu.edu
Bottcher M C
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.94.16.8527
Email
ccthomps@welchlink.welch.jhu.edu
Published
1997-08-05
Pages
8527-32
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC22986
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.94.16.8527 PMC Full Text View journal details
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