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PMID: 8987811 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 16 ·No. 24 ·1996-12-15 ·Pages 7832-40

Thompson CC

Abstract

Proper development of the mammalian CNS requires sufficient thyroid hormone; thyroid hormone deficiency during a brief perinatal period produces severe neurological defects in humans and experimental animals. Thyroid hormone exerts its effects through nuclear receptors, which modulate the transcription of downstream genes in response to hormone binding. Surprisingly, few genes that are regulated by thyroid hormone receptors in the CNS have been described. Here, I report the isolation and characterization of genes that are expressed in response to thyroid hormone in developing rat brain. One such gene (Srg1) encodes a novel protein related to synaptotagmin, a protein involved in regulating neurotransmitter release; another (hr) encodes a putative zinc finger protein related to the product of a recently identified mouse gene, hairless. Both Srg1 and hr are induced rapidly (<4 hr), suggesting that they are regulated directly by thyroid hormone. The temporal and spatial expression of both Srg1 and hr is characteristic of genes important to nervous system development. Srg1 and hr are likely part of a cascade of gene activation induced by thyroid hormone that is critical for CNS organization and development.

MeSH Terms
Aging/metabolism Amino Acid Sequence Animals Animals, Newborn/growth & development,physiology Calcium-Binding Proteins Cerebellum/cytology,growth & development,physiology Female Gene Expression/drug effects Gene Expression Regulation Genes/drug effects Male Membrane Glycoproteins/genetics Molecular Sequence Data Nerve Tissue Proteins/genetics Rats Rats, Sprague-Dawley Sequence Homology Synaptotagmins Thyroid Hormones/pharmacology,physiology Tissue Distribution Transcriptional Activation
Chemicals
Calcium-Binding Proteins Membrane Glycoproteins Nerve Tissue Proteins Thyroid Hormones Synaptotagmins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Thompson C C
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA.
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
0270-6474
Published
1996-12-15
Pages
7832-40
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6579223
Subset
IM
Databases
GENBANK
U71293, U71294
External Links
PubMed source PMC Full Text View journal details
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