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PMID: 3283939 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The steroid and thyroid hormone receptor superfamily.

Science (New York, N.Y.) ·Vol. 240 ·No. 4854 ·1988-05-13 ·Pages 889-95

Evans RM

Abstract

Analyses of steroid receptors are important for understanding molecular details of transcriptional control, as well as providing insight as to how an individual transacting factor contributes to cell identity and function. These studies have led to the identification of a superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid. Although animals employ complex and often distinct ways to control their physiology and development, the discovery of receptor-related molecules in a wide range of species suggests that mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Binding Sites DNA/metabolism Gene Expression Regulation Humans Receptors, Steroid/genetics,physiology Receptors, Thyroid Hormone/genetics,physiology
Chemicals
Receptors, Steroid Receptors, Thyroid Hormone DNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Evans R M
Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92138-9216.
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.3283939
Published
1988-05-13
Pages
889-95
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC6159881
Subset
IM
Grants
Howard Hughes Medical Institute · United States
External Links
PubMed source DOI: 10.1126/science.3283939 PMC Full Text View journal details
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