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PMID: 8980478 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Review

Translational control of cellular and viral mRNAs.

Plant molecular biology ·Vol. 32 ·No. 1-2 ·1996-10-00 ·Pages 145-58

Gallie DR

Abstract

We are becoming increasingly aware of the role that translational control plays in regulating gene expression in plants. There are now many examples in which specific mechanisms have evolved at the translational level that directly impact the amount of protein produced from an mRNA. All regions of an mRNA, i.e., the 5' leader, the coding region, and the 3'-untranslated region, have the potential to influence translation. The 5'-terminal cap structure and the poly(A) tail at the 3' terminus serve as additional elements controlling translation. Many viral mRNAs have evolved alternatives to the cap and poly(A) tail that are functionally equivalent. Nevertheless, for both cellular and viral mRNAs, a co-dependent interaction between the terminal controlling elements appears to be the universal basis for efficient translation.

MeSH Terms
Nucleic Acid Conformation Open Reading Frames Poly A/metabolism Protein Biosynthesis RNA, Messenger/chemistry,genetics RNA, Plant/chemistry,genetics RNA, Viral/chemistry,genetics
Chemicals
RNA, Messenger RNA, Plant RNA, Viral Poly A
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Gallie D R
Department of Biochemistry, University of California, Riverside 92521-0129, USA.
References (103)
103 references, click to expand
  1. Both conserved signals on mammalian histone pre-mRNAs associate with small nuclear ribonucleoproteins during 3' end formation in vitro.
    Mol Cell Biol. 1987 May;7(5):1663-72 PMID: 2955216
  2. Identification of the motifs within the tobacco mosaic virus 5'-leader responsible for enhancing translation.
    Nucleic Acids Res. 1992 Sep 11;20(17):4631-8 PMID: 1408765
  3. Polyadenylation of histone H3 and H4 mRNAs in dicotyledonous plants.
    Gene. 1988 Nov 15;71(1):217-23 PMID: 2905689
  4. A short leader sequence impairs the fidelity of initiation by eukaryotic ribosomes.
    Gene Expr. 1991 May;1(2):111-5 PMID: 1820208
  5. Translation enhancing properties of the 5'-leader of potato virus X genomic RNA.
    FEBS Lett. 1992 Jan 27;296(3):267-70 PMID: 1537401
  6. Protein synthesis and protein phosphorylation during heat stress, recovery, and adaptation.
    J Cell Biol. 1989 Oct;109(4 Pt 1):1467-81 PMID: 2793930
  7. Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F.
    J Biol Chem. 1987 Jan 5;262(1):380-8 PMID: 3793730
  8. Circadian clock mutants in Arabidopsis identified by luciferase imaging.
    Science. 1995 Feb 24;267(5201):1161-3 PMID: 7855595
  9. Histone 3' ends: essential and regulatory functions.
    Gene Expr. 1992;2(2):93-7 PMID: 1633440
  10. Enhanced translation of chimaeric messenger RNAs containing a plant viral untranslated leader sequence.
    Nature. 1987 Feb 12-18;325(6105):622-5 PMID: 3492677
  11. The histone H3 and H4 mRNAs are polyadenylated in maize.
    Nucleic Acids Res. 1988 Feb 25;16(4):1295-304 PMID: 2831497
  12. Translational control of GCN4: an in vivo barometer of initiation-factor activity.
    Trends Biochem Sci. 1994 Oct;19(10):409-14 PMID: 7817398
  13. The sequence between nucleotides 161 and 512 of cowpea mosaic virus M RNA is able to support internal initiation of translation in vitro.
    J Gen Virol. 1991 Oct;72 ( Pt 10):2339-45 PMID: 1919521
  14. Biochemical demonstration of complex formation of histone pre-mRNA with U7 small nuclear ribonucleoprotein and hairpin binding factors.
    EMBO J. 1992 Feb;11(2):691-7 PMID: 1531633
  15. Characterization of RNA-mediated resistance to tomato spotted wilt virus in transgenic tobacco plants.
    Biotechnology (N Y). 1992 Oct;10(10):1133-7 PMID: 1368791
  16. An upstream open reading frame represses expression of Lc, a member of the R/B family of maize transcriptional activators.
    Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8244-8 PMID: 8367489
  17. Translational frameshifting mediated by a viral sequence in plant cells.
    Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2262-6 PMID: 1549592
  18. The tobacco etch viral 5' leader and poly(A) tail are functionally synergistic regulators of translation.
    Gene. 1995 Nov 20;165(2):233-8 PMID: 8522182
  19. A comparison of eukaryotic viral 5'-leader sequences as enhancers of mRNA expression in vivo.
    Nucleic Acids Res. 1987 Nov 11;15(21):8693-711 PMID: 2825117
  20. Visualizing mRNA expression in plant protoplasts: factors influencing efficient mRNA uptake and translation.
    Plant Cell. 1989 Mar;1(3):301-11 PMID: 2535505
  21. The regulation of initiation of mammalian protein synthesis.
    Prog Nucleic Acid Res Mol Biol. 1981;25:127-85 PMID: 6164076
  22. Translation of a polycistronic mRNA in the presence of the cauliflower mosaic virus transactivator protein.
    EMBO J. 1991 Dec;10(12):3887-96 PMID: 1935908
  23. Different complexes are formed on the 3' end of histone mRNA with nuclear and polyribosomal proteins.
    Nucleic Acids Res. 1991 Oct 25;19(20):5653-9 PMID: 1834994
  24. Plant Desiccation and Protein Synthesis : V. Stability of Poly (A) and Poly (A) RNA during Desiccation and Their Synthesis upon Rehydration in the Desiccation-Tolerant Moss Tortula ruralis and the Intolerant Moss Cratoneuron filicinum.
    Plant Physiol. 1984 Apr;74(4):917-22 PMID: 16663533
  25. Mechanism of inhibition of polypeptide chain initiation in heat-shocked Ehrlich cells involves reduction of eukaryotic initiation factor 4F activity.
    J Biol Chem. 1985 Aug 15;260(17):9648-53 PMID: 4019490
  26. The 5' untranslated region of PVY RNA, even located in an internal position, enables initiation of translation.
    Virus Genes. 1993 Dec;7(4):367-79 PMID: 8122396
  27. The anaerobic proteins of maize.
    Cell. 1980 Jul;20(3):761-7 PMID: 7418006
  28. RNA pseudoknot domain of tobacco mosaic virus can functionally substitute for a poly(A) tail in plant and animal cells.
    Genes Dev. 1990 Jul;4(7):1149-57 PMID: 1976569
  29. The heat-shock response in Xenopus oocytes is controlled at the translational level.
    Cell. 1982 Jul;29(3):811-9 PMID: 6891290
  30. An extended RNA/RNA duplex structure within the coding region of mRNA does not block translational elongation.
    Nucleic Acids Res. 1988 Apr 25;16(8):3405-14 PMID: 2453839
  31. Influences of mRNA secondary structure on initiation by eukaryotic ribosomes.
    Proc Natl Acad Sci U S A. 1986 May;83(9):2850-4 PMID: 3458245
  32. Polyadenylated H3 histone transcripts and H3 histone variants in alfalfa.
    Nucleic Acids Res. 1989 Apr 25;17(8):3057-63 PMID: 2471147
  33. Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs.
    Mol Cell Biol. 1989 Nov;9(11):5134-42 PMID: 2601712
  34. Analysis of a translational enhancer upstream from the coat protein open reading frame of potato virus S.
    Arch Virol. 1994;134(3-4):321-33 PMID: 8129619
  35. Changes in the stem-loop at the 3' terminus of histone mRNA affects its nucleocytoplasmic transport and cytoplasmic regulation.
    Nucleic Acids Res. 1994 Nov 11;22(22):4660-6 PMID: 7984415
  36. Cowpea mosaic virus middle component RNA contains a sequence that allows internal binding of ribosomes and that requires eukaryotic initiation factor 4F for optimal translation.
    J Virol. 1991 Jun;65(6):2953-9 PMID: 2033661
  37. Each of the conserved sequence elements flanking the cleavage site of mammalian histone pre-mRNAs has a distinct role in the 3'-end processing reaction.
    Mol Cell Biol. 1989 Jul;9(7):3105-8 PMID: 2779556
  38. Coupling of replication type histone mRNA levels to DNA synthesis requires the stem-loop sequence at the 3' end of the mRNA.
    Proc Natl Acad Sci U S A. 1987 Sep;84(17):6189-93 PMID: 2888112
  39. Sequences controlling histone H4 mRNA abundance.
    EMBO J. 1987 Jun;6(6):1825-31 PMID: 3608993
  40. The 5'-leader sequence of tobacco mosaic virus RNA enhances the expression of foreign gene transcripts in vitro and in vivo.
    Nucleic Acids Res. 1987 Apr 24;15(8):3257-73 PMID: 3575095
  41. A phylogenetically conserved sequence within viral 3' untranslated RNA pseudoknots regulates translation.
    Mol Cell Biol. 1993 Sep;13(9):5331-47 PMID: 8355685
  42. A sequence located 4.5 to 5 kilobases from the 5' end of the barley yellow dwarf virus (PAV) genome strongly stimulates translation of uncapped mRNA.
    J Biol Chem. 1995 Jun 2;270(22):13446-52 PMID: 7768947
  43. Heat Shock Disrupts Cap and Poly(A) Tail Function during Translation and Increases mRNA Stability of Introduced Reporter mRNA.
    Plant Physiol. 1995 Aug;108(4):1703-1713 PMID: 12228574
  44. Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency.
    Cell. 1985 Mar;40(3):515-26 PMID: 2982496
  45. Cell-specific expression of plant histone H2A genes.
    Plant Cell. 1991 Jul;3(7):657-65 PMID: 1841722
  46. Influence of Protoplasmic Water Loss on the Control of Protein Synthesis in the Desiccation-Tolerant Moss Tortula ruralis: Ramifications for a Repair-Based Mechanism of Desiccation Tolerance.
    Plant Physiol. 1991 Dec;97(4):1501-11 PMID: 16668577
  47. The organization and expression of histone gene families.
    Cell. 1981 Aug;25(2):301-13 PMID: 6793234
  48. Point mutations in the stem-loop at the 3' end of mouse histone mRNA reduce expression by reducing the efficiency of 3' end formation.
    Mol Cell Biol. 1994 Mar;14(3):1709-20 PMID: 8114706
  49. Identification of the human U7 snRNP as one of several factors involved in the 3' end maturation of histone premessenger RNA's.
    Science. 1987 Dec 18;238(4834):1682-7 PMID: 2825355
  50. Translational control of protein synthesis in response to heat shock in D. melanogaster cells.
    Cell. 1980 Dec;22(3):825-34 PMID: 6780199
  51. The absence of a m7G cap on beta-globin mRNA and alfalfa mosaic virus RNA 4 increases the amounts of initiation factor 4F required for translation.
    J Biol Chem. 1990 Nov 15;265(32):19582-7 PMID: 2246243
  52. Organization and transcription of Volvox histone-encoding genes: similarities between algal and animal genes.
    Gene. 1990 Sep 14;93(2):167-75 PMID: 2227431
  53. The 5' untranslated region from pea seedborne mosaic potyvirus RNA as a translational enhancer in pea and tobacco protoplasts.
    FEBS Lett. 1992 Jun 1;303(2-3):169-72 PMID: 1607015
  54. Cap-independent enhancement of translation by a plant potyvirus 5' nontranslated region.
    J Virol. 1990 Apr;64(4):1590-7 PMID: 2319646
  55. Regulation of caulimovirus gene expression and the involvement of cis-acting elements on both viral transcripts.
    Virology. 1992 Sep;190(1):403-12 PMID: 1529539
  56. Formation of cytoplasmic heat shock granules in tomato cell cultures and leaves.
    Mol Cell Biol. 1983 Sep;3(9):1648-55 PMID: 6633535
  57. The heat-shock response.
    Annu Rev Biochem. 1986;55:1151-91 PMID: 2427013
  58. Role of the Leader Sequence during Thermal Repression of Translation in Maize, Tobacco, and Carrot Protoplasts.
    Plant Physiol. 1992 Dec;100(4):1827-33 PMID: 16653204
  59. Multiple processing-defective mutations in a mammalian histone pre-mRNA are suppressed by compensatory changes in U7 RNA both in vivo and in vitro.
    Genes Dev. 1991 Sep;5(9):1709-22 PMID: 1885007
  60. Regulation of histone mRNA in the unperturbed cell cycle: evidence suggesting control at two posttranscriptional steps.
    Mol Cell Biol. 1991 May;11(5):2416-24 PMID: 2017161
  61. Evidence that the 5'-untranslated leader of mRNA affects the requirement for wheat germ initiation factors 4A, 4F, and 4G.
    J Biol Chem. 1988 Jul 15;263(20):9630-4 PMID: 3260235
  62. The organization structure and regulatory elements of Chlamydomonas histone genes reveal features linking plant and animal genes.
    Curr Genet. 1995 Sep;28(4):333-45 PMID: 8590479
  63. The dynamic state of heat shock proteins in chicken embryo fibroblasts.
    J Cell Biol. 1986 Oct;103(4):1495-507 PMID: 3533955
  64. Inactivation of mRNA cap-binding protein complex in Drosophila melanogaster embryos under heat shock.
    J Biol Chem. 1991 Aug 25;266(24):16007-14 PMID: 1908463
  65. The 5' and 3' untranslated regions of satellite tobacco necrosis virus RNA affect translational efficiency and dependence on a 5' cap structure.
    J Biol Chem. 1993 May 5;268(13):9504-10 PMID: 8486640
  66. The histone 3'-terminal stem-loop is necessary for translation in Chinese hamster ovary cells.
    Nucleic Acids Res. 1996 May 15;24(10):1954-62 PMID: 8657580
  67. Post-transcriptional regulation in higher eukaryotes: the role of the reporter gene in controlling expression.
    Mol Gen Genet. 1991 Aug;228(1-2):258-64 PMID: 1886610
  68. Cytoplasmic heat shock granules are formed from precursor particles and are associated with a specific set of mRNAs.
    Mol Cell Biol. 1989 Mar;9(3):1298-308 PMID: 2725500
  69. Ribosomes pause at specific sites during synthesis of membrane-bound chloroplast reaction center protein D1.
    J Biol Chem. 1991 Aug 15;266(23):14931-8 PMID: 1869532
  70. Plant Desiccation and Protein Synthesis : VI. Changes in Protein Synthesis Elicited by Desiccation of the Moss Tortula ruralis are Effected at the Translational Level.
    Plant Physiol. 1984 Apr;74(4):923-7 PMID: 16663534
  71. Histone genes of Volvox carteri: DNA sequence and organization of two H3-H4 gene loci.
    Nucleic Acids Res. 1988 May 11;16(9):4121-36 PMID: 2836811
  72. In vitro transcription and translational efficiency of chimeric SP6 messenger RNAs devoid of 5' vector nucleotides.
    Nucleic Acids Res. 1988 May 25;16(10):4483-98 PMID: 3260027
  73. Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.
    Mol Cell Biol. 1990 Mar;10(3):1134-44 PMID: 2304461
  74. The sequence of the stem and flanking sequences at the 3' end of histone mRNA are critical determinants for the binding of the stem-loop binding protein.
    Nucleic Acids Res. 1995 Feb 25;23(4):654-62 PMID: 7899087
  75. An inspection of the domain between putative TATA box and translation start site in 79 plant genes.
    Nucleic Acids Res. 1987 Aug 25;15(16):6643-53 PMID: 3628002
  76. The stem-loop structure at the 3' end of histone mRNA is necessary and sufficient for regulation of histone mRNA stability.
    Mol Cell Biol. 1987 Dec;7(12):4557-9 PMID: 3437896
  77. Ribosome pausing and stacking during translation of a eukaryotic mRNA.
    EMBO J. 1988 Nov;7(11):3559-69 PMID: 2850168
  78. Conserved terminal hairpin sequences of histone mRNA precursors are not involved in duplex formation with the U7 RNA but act as a target site for a distinct processing factor.
    Proc Natl Acad Sci U S A. 1989 Jun;86(12):4345-9 PMID: 2734288
  79. Environmental stress-mediated differential 3' end formation of chloroplast RNA-binding protein transcripts.
    Plant Mol Biol. 1994 Nov;26(3):833-49 PMID: 7999998
  80. Plant viral leaders influence expression of a reporter gene in tobacco.
    Plant Mol Biol. 1993 Oct;23(1):97-109 PMID: 8219060
  81. Mature mRNA 3' end formation stimulates RNA export from the nucleus.
    EMBO J. 1991 Nov;10(11):3513-22 PMID: 1833188
  82. Small heat shock proteins of Drosophila associate with the cytoskeleton.
    Proc Natl Acad Sci U S A. 1986 Jan;83(1):90-4 PMID: 3079906
  83. Heat shock proteins of higher plants.
    Proc Natl Acad Sci U S A. 1981 Jun;78(6):3526-30 PMID: 16593032
  84. Ribosomes pause during the expression of the large ATP synthase gene cluster in spinach chloroplasts.
    Plant Physiol. 1994 Aug;105(4):1167-77 PMID: 7972492
  85. Heat shock impairs the interaction of cap-binding protein complex with 5' mRNA cap.
    J Biol Chem. 1991 Feb 15;266(5):2789-94 PMID: 1993658
  86. The 3' untranslated region of satellite tobacco necrosis virus RNA stimulates translation in vitro.
    Mol Cell Biol. 1993 Jun;13(6):3340-9 PMID: 8497255
  87. Localization of in vivo ribosome pause sites.
    Anal Biochem. 1992 Oct;206(1):183-8 PMID: 1456432
  88. The 5'-untranslated leader sequence of potato virus X RNA enhances the expression of a heterologous gene in vivo.
    Mol Gen Genet. 1992 Aug;234(2):329-31 PMID: 1324400
  89. Differential utilization of alternate initiation sites in a plant defense gene responding to environmental stimuli.
    Eur J Biochem. 1994 Nov 15;226(1):109-14 PMID: 7957237
  90. Evidence for an internal ribosome entry site within the 5' non-translated region of turnip mosaic potyvirus RNA.
    J Gen Virol. 1994 Nov;75 ( Pt 11):3157-65 PMID: 7964625
  91. Translation of the mRNA of the maize transcriptional activator Opaque-2 is inhibited by upstream open reading frames present in the leader sequence.
    Plant Cell. 1993 Jan;5(1):65-73 PMID: 8439744
  92. Isolation and characterization of the 102-kilodalton RNA-binding protein that binds to the 5' and 3' translational enhancers of tobacco mosaic virus RNA.
    J Biol Chem. 1996 Jun 14;271(24):14316-22 PMID: 8663059
  93. Poly(A) binds to initiation factors and increases cap-dependent translation in vitro.
    J Biol Chem. 1994 Jun 24;269(25):17166-73 PMID: 8006024
  94. Hypoxia enhances phosphorylation of eukaryotic initiation factor 4A in maize root tips.
    J Biol Chem. 1991 Dec 5;266(34):23341-6 PMID: 1744128
  95. 5' untranslated leader sequences of eukaryotic mRNAs encoding heat shock induced proteins.
    Nucleic Acids Res. 1995 Feb 25;23(4):541-9 PMID: 7899073
  96. Expression of a phosphorylation-resistant eukaryotic initiation factor 2 alpha-subunit mitigates heat shock inhibition of protein synthesis.
    J Biol Chem. 1993 Jun 15;268(17):12946-51 PMID: 8509427
  97. Characterization of a potato leafroll luteovirus subgenomic RNA: differential expression by internal translation initiation and UAG suppression.
    J Gen Virol. 1990 Oct;71 ( Pt 10):2265-72 PMID: 2230734
  98. The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.
    Genes Dev. 1991 Nov;5(11):2108-16 PMID: 1682219
  99. The regulation of gene expression in transformed maize aleurone and endosperm protoplasts. Analysis of promoter activity, intron enhancement, and mRNA untranslated regions on expression.
    Plant Physiol. 1994 Nov;106(3):929-39 PMID: 7824660
  100. A plant plasma membrane proton-ATPase gene is regulated by development and environment and shows signs of a translational regulation.
    Plant Cell. 1994 Oct;6(10):1375-89 PMID: 7994172
  101. Cellular localization of HSP23 during Drosophila development and following subsequent heat shock.
    Dev Biol. 1987 Jul;122(1):39-48 PMID: 3109982
  102. The role of the 3'-untranslated region of non-polyadenylated plant viral mRNAs in regulating translational efficiency.
    Gene. 1994 May 16;142(2):159-65 PMID: 8194747
  103. Developmental control of the heat shock response in Xenopus.
    Proc Natl Acad Sci U S A. 1984 May;81(10):3138-42 PMID: 6203112
Article Info
Journal
Plant molecular biology
Abbr.
Plant Mol Biol
ISSN
0167-4412
DOI
10.1007/BF00039381
Published
1996-10-00
Pages
145-58
Language
English
Region
Netherlands
NLM ID
9106343
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00039381 View journal details
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