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PMID: 8835526 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Sub-milliMorgan map of the proximal part of mouse Chromosome 17 including the hybrid sterility 1 gene.

Mammalian genome : official journal of the International Mammalian Genome Society ·Vol. 7 ·No. 2 ·1996-02-00 ·Pages 107-13

Gregorová S, Mnuková-Fajdelová M, Trachtulec Z, Capková J, Loudová M, Hoglund M, Hamvas R, Lehrach H, Vincek V, Klein J, Forejt J

Abstract

We have generated a high-resolution genetic map, 0.071 cM per backcross animal, of the 13 cM T-H2 region of the mouse Chromosome (Chr) 17. The map contains two phenotypic loci, T and Hst1, 12 RFLP markers, and 24 microsatellite loci. The Hst1 gene was mapped to a chromosomal interval contained within a single 580-kb YAC clone. The FFEH11 YAC is 0.44 cM long and carries, besides the Hst1 gene, five polymorphic DNA markers and recombination breakpoints of six backcross animals. Two candidate genes for Hst1 were identified based on their location and testicular expression. These are Tbp and D17Ph4e. The submilliMorgan map of the T-H2 region revealed significant clustering of (CA)n loci. The clustering, if shown to be a common feature in the mouse genome, may cause gaps in the physical map of the mouse genome.

MeSH Terms
Animals Base Sequence Chromosome Mapping DNA Primers Female Genetic Markers Genotype H-2 Antigens/genetics Hybridization, Genetic Infertility, Male/genetics Male Mice Mice, Inbred C3H Mice, Inbred C57BL Molecular Sequence Data Multigene Family Polymorphism, Restriction Fragment Length Polymorphism, Single-Stranded Conformational Recombination, Genetic
Chemicals
DNA Primers Genetic Markers H-2 Antigens
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Gregorová S
Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague.
Mnuková-Fajdelová M
Trachtulec Z
Capková J
Loudová M
Hoglund M
Hamvas R
Lehrach H
Vincek V
Klein J
Forejt J
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Article Info
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
Abbr.
Mamm Genome
ISSN
0938-8990
DOI
10.1007/s003359900029
Published
1996-02-00
Pages
107-13
Language
English
Region
United States
NLM ID
9100916
Subset
IM
Grants
NICHD NIH HHS · HD28395-02 · United States
External Links
PubMed source DOI: 10.1007/s003359900029 View journal details
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