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PMID: 1799792 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Genetic mapping of the t-complex region on mouse chromosome 17 including the Hybrid sterility-1 gene.

Mammalian genome : official journal of the International Mammalian Genome Society ·Vol. 1 ·No. 2 ·1991-00-00 ·Pages 84-91

Forejt J, Vincek V, Klein J, Lehrach H, Loudová-Micková M

Abstract

t-haplotypes occupy a region on chromosome (Chr) 17 which slightly overlaps the ends of the T-H-2 interval. The wild-type form of this 14 centi-Morgan (cM) region was mapped in a multilocus backcross (C57BL/10-T x C3H)F1 x C57BL/10 using 15 DNA probes on Southern blots of the DNA extracted from 53 animals which were recombinants in the T-H-2 interval. Each recombinant was also progeny-tested to ascertain its Hybrid sterility-1 (Hst-1) genotype by crossing to PWB/Ph, a Mus musculus-derived inbred strain. The limit of resolution of the cross was 0.27 cM. The map distances have been determined for the DNA loci in the T-H-2 interval and the Hst-1 gene was mapped in close vicinity to the D17Rp17 locus.

Related Genes
D17Tu5 H-2K Hba-ps4 Hst-1 Pim-1 Sod-2 Tcp-1
MeSH Terms
Animals Chromosome Mapping Crosses, Genetic DNA Probes Female H-2 Antigens/genetics Hybridization, Genetic/genetics Infertility/genetics Male Mice/genetics Mice, Mutant Strains
Chemicals
DNA Probes H-2 Antigens
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Forejt J
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague.
Vincek V
Klein J
Lehrach H
Loudová-Micková M
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Article Info
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
Abbr.
Mamm Genome
ISSN
0938-8990
DOI
10.1007/BF02443783
Published
1991-00-00
Pages
84-91
Language
English
Region
United States
NLM ID
9100916
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02443783 View journal details
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