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PMID: 8795573 Published · ppublish English Journal Article Review

Do heat shock proteins have a role in breast cancer?

British journal of cancer ·Vol. 74 ·No. 5 ·1996-09-00 ·Pages 717-21

Conroy SE, Latchman DS

Abstract

It is clear therefore that hsps are overexpressed in patients with malignant tumours compared with healthy controls and this overexpression does show some correlation with disease features. Furthermore, expression of hsps has been reported on the cell surface of tumour cell lines. This could be associated with the immune response which has been reported with hsp90 and which also correlates with some disease features. It now appears that hsps may be involved in the presentation of tumour antigens leading to the possibility of hsps being used as a means of therapy. Hsp65 expression has not been investigated in patients with breast cancer. However, transfection of bacterial hsp65 into a tumour cell line resulted in the hsp65-expressing tumour cells losing their tumorigenicity in mice (Lukacs et al., 1993). Thus, hsps and the immune response to them are of interest as diagnostic and prognostic tools as well as a novel form of immunotherapy.

MeSH Terms
Animals Antibodies, Neoplasm/immunology Breast Neoplasms/immunology,metabolism,pathology Female Heat-Shock Proteins/biosynthesis,classification,immunology Humans Mice
Chemicals
Antibodies, Neoplasm Heat-Shock Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Conroy S E
Medical Molecular Biology Unit, Department of Molecular Pathology, London, UK.
Latchman D S
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44 references, click to expand
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1996.427
Published
1996-09-00
Pages
717-21
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2074714
Subset
IM
External Links
PubMed source DOI: 10.1038/bjc.1996.427 PMC Full Text View journal details
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