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PMID: 1960683 Published · ppublish English Journal Article Review

Heat shock proteins and human disease.

Journal of the Royal College of Physicians of London ·Vol. 25 ·No. 4 ·1991-10-00 ·Pages 295-9

Latchman DS

Abstract

At first sight it appears unlikely that a phenomenon which was first observed in 1962 as the appearance of specific puffs in the salivary gland chromosomes of the larvae of the fruit fly Drosophila busckii following exposure to elevated temperature [1] should, nearly 30 years later, attract considerable attention from clinicians and scientists interested in such diverse phenomena as autoimmune diabetes and myocardial infarction [2, 3]. The aim of this review is to discuss the information which has been accumulated about the heat shock proteins in the 30 years since their discovery and to indicate how this information has led to studies on their possible role in human disease.

MeSH Terms
Animals Arthritis, Rheumatoid/physiopathology Autoimmune Diseases/physiopathology Heart Diseases/physiopathology Heat-Shock Proteins/physiology Humans
Chemicals
Heat-Shock Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Latchman D S
Department of Biochemistry, University College and Middlesex School of Medicine, London.
References (26)
26 references, click to expand
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Article Info
Journal
Journal of the Royal College of Physicians of London
Abbr.
J R Coll Physicians Lond
ISSN
0035-8819
Published
1991-10-00
Pages
295-9
Language
English
Region
England
NLM ID
7503108
PMCID
PMC5377192
Subset
IM
External Links
PubMed source PMC Full Text
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