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PMID: 8781117 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma.

Immunogenetics ·Vol. 44 ·No. 5 ·1996-00-00 ·Pages 323-30

Gaugler B, Brouwenstijn N, Vantomme V, Szikora JP, Van der Spek CW, Patard JJ, Boon T, Schrier P, Van den Eynde BJ

Abstract

Previous reports have described antigens that are recognized on human melanoma cells by autologous cytolytic T lymphocytes (CTL). The genes coding for a number of these antigens have been identified. Here we report the cloning of a gene that codes for an antigen recognized by autologous CTL on a human renal carcinoma cell line. This antigen is presented by HLA-B7 and is encoded by a new gene that we have named RAGE1. No expression of RAGE1 was found in normal tissues other than retina. RAGE1 expression was found in only one of 57 renal cell carcinoma samples, and also in some sarcomas, infiltrating bladder carcinomas, and melanomas. This represents the first identification of an antigen recognized by autologous CTL on a renal tumor.

MeSH Terms
Amino Acid Sequence Animals Antigen Presentation Antigens, Neoplasm/analysis,genetics,immunology Base Sequence Carcinoma, Renal Cell/immunology Cell Line, Transformed Chlorocebus aethiops DNA, Complementary/genetics Eye Proteins/analysis,genetics,immunology Genes HLA-B7 Antigen/immunology Humans Kidney Neoplasms/immunology Mitogen-Activated Protein Kinases Molecular Sequence Data Neoplasms/immunology Retina/immunology Sequence Alignment Sequence Homology T-Lymphocytes, Cytotoxic/immunology Transfection
Chemicals
Antigens, Neoplasm DNA, Complementary Eye Proteins HLA-B7 Antigen MOK protein, human Mitogen-Activated Protein Kinases
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Gaugler B
Ludwig Institute for Cancer Research, Brussels Branch, 74 avenue Hippocrate, UCL 7459, B1200 Brussels, Belgium.
Brouwenstijn N
Vantomme V
Szikora J P
Van der Spek C W
Patard J J
Boon T
Schrier P
Van den Eynde B J
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF02602776
Published
1996-00-00
Pages
323-30
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Databases
GENBANK
U46191, U46192, U46193, U46194
External Links
PubMed source DOI: 10.1007/BF02602776 View journal details
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