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PMID: 8567399 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Intratumoral injection of an adriamycin immunoconjugate against human pancreatic cancer xenografts.

Japanese journal of cancer research : Gann ·Vol. 86 ·No. 11 ·1995-11-00 ·Pages 1072-9

Kondo Y, Chung YS, Sawada T, Inui A, Yamashita Y, Hirayama K, Nakata B, Ho JJ, Kim YS, Sowa M

Abstract

We have evaluated the effect of an adriamycin conjugate of monoclonal antibody Nd2 (ADM-Nd2) on the growth rate of SW1990 xenografts grown subcutaneously in athymic nude mice. Intravenous or intraperitoneal administration of radiolabeled Nd2 resulted in a maximum tumor accumulation of approximately 45% of the initial dose/g of tumor 3-7 days after administration. However, administration into the tumor produced retention of 1200%ID/g 1 day after, with 50% of this high value remaining even at 7 days after administration. In contrast, intratumoral administration of a non-specific immunoglobulin showed a lower initial retention and rapid loss of label. Both intravenously and intratumorally administered ADM-Nd2 reduced the growth rate of SW1990 xenografts. While a single intravenous administration arrested growth for about two weeks, a single intratumoral injection prevented any increase in tumor size even 45 days after administration. Xenografts treated with ADM-Nd2 showed degenerative changes at the histological level. Neither Nd2 alone nor Adriamycin alone inhibited growth when administered at the same dose as the conjugate.

MeSH Terms
Animals Antibodies, Monoclonal/administration & dosage,immunology Antibodies, Neoplasm/administration & dosage,immunology Doxorubicin/administration & dosage,therapeutic use Drug Screening Assays, Antitumor Humans Immunoconjugates/administration & dosage,therapeutic use Injections, Intralesional Mice Mice, Inbred BALB C Mice, Nude Mucins/immunology Neoplasm Proteins/immunology Neoplasm Transplantation Pancreatic Neoplasms/drug therapy Transplantation, Heterologous
Chemicals
Antibodies, Monoclonal Antibodies, Neoplasm Immunoconjugates Mucins Neoplasm Proteins Doxorubicin
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Kondo Y
First Department of Surgery, Osaka City University Medical School.
Chung Y S
Sawada T
Inui A
Yamashita Y
Hirayama K
Nakata B
Ho J J
Kim Y S
Sowa M
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Article Info
Journal
Japanese journal of cancer research : Gann
Abbr.
Jpn J Cancer Res
ISSN
0910-5050
Published
1995-11-00
Pages
1072-9
Language
English
Region
Japan
NLM ID
8509412
PMCID
PMC5920632
Subset
IM
Grants
NCI NIH HHS · CA24321 · United States
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