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PMID: 833548 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Histocompatibility antigens controlled by the I region of the murine H-2 complex. II. K/D region compatibility is not required for I-region cell-mediated lymphocytotoxicity.

The Journal of experimental medicine ·Vol. 145 ·No. 2 ·1977-02-01 ·Pages 450-4

Klein J, Chiang CL, Hauptfeld V

Abstract

In the cell-mediated lymphocytotoxicity assay, A.TH effector cells sensitized to A.TL lymphocytes lyse not only A.B10.AQR effector cells lyse B10.BR and B10.BYR target cells in addition to B10.AQR cells. These findings indicate that for CML to occur across the IA region barrier, compatibility at K or D regions is not required.

MeSH Terms

Animals Cytotoxicity Tests, Immunologic Female Genes Genetic Linkage Histocompatibility Antigens Immunity, Cellular Immunologic Memory Male Mice

Chemicals

Histocompatibility Antigens

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Klein J

Chiang C L

Hauptfeld V

References (15)

15 references, click to expand

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.
Nature. 1974 Apr 19;248(5450):701-2 PMID: 4133807
I-region-associated determinants: expression on mitogen-stimulated lymphocytes and detection by cytotoxic T cells.
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Graft-versus-host reactions across different regions of the H-2 complex of the mouse.
J Exp Med. 1973 May 1;137(5):1213-25 PMID: 4144985
Cell-mediated lympholysis. Importance of serologically defined H-2 regions.
J Exp Med. 1973 May 1;137(5):1303-9 PMID: 4267208
A major role for the Ir-1 region of the mouse H-2 complex in the mixed leukocyte reaction.
Transplant Proc. 1973 Mar;5(1):377-81 PMID: 4266664
Induction of cytotoxic T lymphocytes against I-region-coded determinants: in vitro evidence for a third histocompatibility locus in the mouse.
J Exp Med. 1975 Dec 1;142(6):1477-87 PMID: 53265
Serological identification of an Ir-region product.
Science. 1973 Jul 13;181(4095):167-9 PMID: 4541239
Genetic and immunological complexity of major histocompatibility regions.
Science. 1972 Jun 2;176(4038):1024-7 PMID: 4555921
Genetic control of the immune response. Mapping of the Ir-1 locus.
J Exp Med. 1972 Jun 1;135(6):1259-78 PMID: 4554451
New lymphocyte antigen system (Lna) controlled by the Ir region of the mouse H-2 complex.
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2509-14 PMID: 4517664
Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex.
Nature. 1975 Mar 20;254(5497):269-70 PMID: 1078719
On the role of the H-2 histocompatibility complex in determining the specificity of cytotoxic effector cells sensitized against syngeneic trinitrophenyl-modified targets.
J Exp Med. 1975 Aug 1;142(2):403-18 PMID: 1079848
In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.
J Exp Med. 1975 Nov 1;142(5):1108-20 PMID: 1081575
Histocompatibility antigens controlled by the I region of the murine H-2 complex. I. Mapping of H-2A and H-2C loci.
J Exp Med. 1976 Jun 1;143(6):1439-52 PMID: 775014
The major histocompatibility complex determines susceptibility to cytotoxic T cells directed against minor histocompatibility antigens.
J Exp Med. 1975 Dec 1;142(6):1349-64 PMID: 53263

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.145.2.450

Published

1977-02-01

Pages

450-4

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2180608

Subset

External Links

PubMed source DOI: 10.1084/jem.145.2.450 PMC Full Text View journal details

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Histocompatibility antigens controlled by the I region of the murine H-2 complex. II. K/D region compatibility is not required for I-region cell-mediated lymphocytotoxicity.

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