Genetic and immunological complexity of major histocompatibility regions.

Science (New York, N.Y.) ·Vol. 176 ·No. 4038 ·1972-06-02 ·Pages 1024-7

Bach FH, Widmer MB, Segall M, Bach ML, Klein J

Abstract

There are genetic differences within the major histocompatibility complex of the mouse which lead to skin graft rejection but which cannot be detected serologically. When confronted with these differences on allogeneic cells, lymphocytes proliferate in vitro. In other cases, in vitro lymphocyte proliferation but no skin graft rejection is associated with loci that are linked to but genetically separable from the loci controlling the serologically defined antigens.

MeSH Terms

Alleles Animals Antigens Chromosome Mapping Genes Histocompatibility Histocompatibility Testing Lymphocyte Activation Lymphocytes/immunology,metabolism Mice Mitomycins/pharmacology Mutation Recombination, Genetic Skin Transplantation Thymidine/metabolism Transplantation Immunology Transplantation, Homologous

Chemicals

Antigens Mitomycins Thymidine

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Bach F H

Widmer M B

Segall M

Bach M L

Klein J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.176.4038.1024

Published

1972-06-02

Pages

1024-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.176.4038.1024 View journal details

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